| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Redmile Group, LLC | 8.09M (9.29%) | 4.42M Increased by +54.55% | Dec 31, 25 |
| 2 | Deep Track Capital, LP | 7.04M (8.08%) | 979.43K Increased by +13.92% | Dec 31, 25 |
| 3 | BlackRock Inc | 6.76M (7.76%) | -46.11K Decreased by -0.68% | Sep 30, 25 |
| 4 | Vanguard Group Inc | 5.95M (6.83%) | 1.46M Increased by +24.55% | Dec 31, 25 |
| 5 | General Atlantic Llc | 4.90M (5.62%) | 4.90M Increased by +100.00% | Dec 31, 25 |
| 6 | Vestal Point Capital LP | 4.69M (5.38%) | 1.22M Increased by +25.91% | Dec 31, 25 |
| 7 | Baker Bros Advisors LP | 4.66M (5.35%) | 776.43K Increased by +16.67% | Dec 31, 25 |
| 8 | FMR Inc | 4.23M (4.86%) | -4.65M Decreased by -109.90% | Dec 31, 25 |
| 9 | Pictet Asset Manangement SA | 3.47M (3.98%) | 1.49M Increased by +42.88% | Dec 31, 25 |
| 10 | Point72 Asset Management, L.P. | 3.21M (3.69%) | 340.18K Increased by +10.59% | Dec 31, 25 |
| 11 | T. Rowe Price Associates, Inc. | 3.03M (3.48%) | 120.48K Increased by +3.97% | Jun 30, 25 |
| 12 | State Street Corp | 2.86M (3.28%) | 330.23K Increased by +11.54% | Sep 30, 25 |
| 13 | Wasatch Advisors Inc. | 2.75M (3.16%) | -814.87K Decreased by -29.63% | Dec 31, 23 |
| 14 | State Street Corporation | 2.73M (3.13%) | 1.81M Increased by +66.24% | Mar 31, 24 |
| 15 | Deutsche Bank AG | 2.49M (2.85%) | 1.05M Increased by +42.14% | Dec 31, 25 |
| 16 | T. Rowe Price Investment Management,Inc. | 2.47M (2.84%) | 45.67K Increased by +1.85% | Jun 30, 25 |
| 17 | Rubric Capital Management LP | 2.47M (2.84%) | 2.47M Increased by +100.00% | Dec 31, 25 |
| 18 | Soleus Capital Management, L.P. | 2.42M (2.78%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 19 | Geode Capital Management, LLC | 2.38M (2.74%) | 502.32K Increased by +21.06% | Dec 31, 25 |
| 20 | COMMODORE CAPITAL LP | 2.27M (2.61%) | -1.51M Decreased by -66.16% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 3.20M (3.68%) | -73.08K Decreased by -2.28% | Feb 28, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 2.81M (3.22%) | 42.28K Increased by +1.50% | Mar 31, 26 |
| 3 | iShares Russell 2000 ETF | 2.46M (2.82%) | -20.07K Decreased by -0.82% | Mar 31, 26 |
| 4 | Pictet-Biotech P USD | 2.27M (2.60%) | 311.65K Increased by +13.76% | Dec 31, 25 |
| 5 | Xtrackers MSCI World Swap ETF 1C | 2.14M (2.46%) | -13.47K Decreased by -0.63% | Dec 31, 25 |
| 6 | Vanguard US Total Market Shares ETF | 2.13M (2.44%) | 196.50K Increased by +9.23% | Sep 30, 24 |
| 7 | Fidelity Select Health Care | 1.69M (1.94%) | 90.00K Increased by +5.33% | Jul 31, 25 |
| 8 | ARK Genomic Revolution ETF | 1.64M (1.88%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 9 | ARK Genomic Revolution | 1.53M (1.76%) | 68.92K Increased by +4.51% | Dec 31, 25 |
| 10 | US Small-Cap Growth II Equity Comp | 1.35M (1.55%) | 14.21K Increased by +1.05% | Jun 30, 25 |
| 11 | Eventide Healthcare & Life Sciences I | 1.30M (1.49%) | 1.30M Increased by +100.00% | Dec 31, 25 |
| 12 | Nikko AM ARK Pstv Chg Innovt P JPY Acc | 1.10M (1.26%) | 273.18K Increased by +24.86% | Jun 30, 25 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 1.05M (1.20%) | 12.28K Increased by +1.17% | Feb 28, 26 |
| 14 | Strategic Advisers Fidelity US TtlStk | 1.03M (1.19%) | 20.00K Increased by +1.93% | Jul 31, 25 |
| 15 | Fidelity Advisor Health Care I | 1.00M (1.15%) | 50.00K Increased by +5.00% | Jul 31, 25 |
| 16 | T. Rowe Price New Horizons | 999.63K (1.15%) | -348.37K Decreased by -34.85% | Jul 31, 25 |
| 17 | T. Rowe Price Integrated US SmCapGrEq | 985.71K (1.13%) | 492.85K Increased by +50.00% | Dec 31, 24 |
| 18 | Amova ARK Pstv Chg Innovt P JPY Acc | 985.28K (1.13%) | -20.89K Decreased by -2.12% | Feb 28, 26 |
| 19 | Fidelity Small Cap Index | 969.70K (1.11%) | -13.25K Decreased by -1.37% | Jan 31, 26 |
| 20 | Fidelity Small Cap Growth | 948.30K (1.09%) | 0.00 Increased by 0.00% | Jan 31, 26 |