| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 3.37M (17.92%) | 2.27M Increased by +67.53% | Jun 30, 25 |
| 2 | Bain Capital Life Sciences Investors, LLC | 2.50M (13.31%) | 1.80M Increased by +71.88% | Jun 30, 25 |
| 3 | Point72 Asset Management, L.P. | 1.53M (8.13%) | 1.41M Increased by +92.55% | Jun 30, 25 |
| 4 | Vivo Capital, LLC | 1.31M (6.98%) | 627.15K Increased by +47.82% | Jun 30, 25 |
| 5 | COMMODORE CAPITAL LP | 1.18M (6.26%) | 1.18M Increased by +100.00% | Jun 30, 25 |
| 6 | TCG Crossover Management, LLC | 1.01M (5.35%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 7 | Adage Capital Partners Gp LLC | 990.00K (5.27%) | 620.05K Increased by +62.63% | Mar 31, 25 |
| 8 | Vanguard Group Inc | 966.71K (5.15%) | 457.13K Increased by +47.29% | Jun 30, 25 |
| 9 | Bvf Inc | 786.39K (4.19%) | -138.25K Decreased by -17.58% | Jun 30, 25 |
| 10 | Darwin Global Management, Ltd. | 768.42K (4.09%) | 768.42K Increased by +100.00% | Jun 30, 25 |
| 11 | VR Adviser, LLC | 639.09K (3.40%) | -412.43K Decreased by -64.53% | Jun 30, 25 |
| 12 | HHG PLC | 625.00K (3.33%) | 625.00K Increased by +100.00% | Jun 30, 25 |
| 13 | GSA Capital Partners LLP | 540.45K (2.88%) | 403.47K Increased by +74.66% | Dec 31, 23 |
| 14 | Vestal Point Capital LP | 500.00K (2.66%) | -4.54K Decreased by -0.91% | Jun 30, 25 |
| 15 | Ikarian Capital, LLC | 464.49K (2.47%) | 215.55K Increased by +46.41% | Jun 30, 25 |
| 16 | Soleus Capital Management, L.P. | 462.81K (2.46%) | 462.81K Increased by +100.00% | Jun 30, 25 |
| 17 | Monashee Investment Management LLC | 369.10K (1.96%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 18 | West Family Investments LLC | 368.91K (1.96%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 19 | Susquehanna International Group, LLP | 342.48K (1.82%) | 299.85K Increased by +87.55% | Mar 31, 25 |
| 20 | Connor Clark & Lunn Inv Mgmt Ltd | 316.83K (1.69%) | -12.37K Decreased by -3.90% | Dec 31, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | MEDICAL BioHealth EUR Acc | 903.90K (4.81%) | -1.06M Decreased by -117.68% | Jan 31, 24 |
| 2 | APO Medical Opportunities R | 777.57K (4.14%) | -484.29K Decreased by -62.28% | Jan 31, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 592.28K (3.15%) | -13.13K Decreased by -2.22% | Jul 31, 25 |
| 4 | Fidelity® Extended Market Index | 430.40K (2.29%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 5 | iShares Russell 2000 ETF | 404.28K (2.15%) | -4.54K Decreased by -1.12% | Aug 29, 25 |
| 6 | RIM Global Bioscience EUR | 284.96K (1.52%) | -153.79K Decreased by -53.97% | Dec 31, 23 |
| 7 | BlackRock Extended Mkt Composite | 228.25K (1.22%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 8 | abrdn Healthcare Investors | 179.90K (0.96%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 9 | Fidelity Small Cap Index | 168.54K (0.90%) | 168.54K Increased by +100.00% | Jun 30, 25 |
| 10 | Vanguard Institutional Extnd Mkt Idx Tr | 159.67K (0.85%) | -69.89K Decreased by -43.77% | Jul 31, 25 |
| 11 | iShares Russell 2000 Value ETF | 147.78K (0.79%) | -327.00 Decreased by -0.22% | Aug 29, 25 |
| 12 | Fidelity Select Health Care | 140.00K (0.75%) | 140.00K Increased by +100.00% | Jul 31, 25 |
| 13 | Fidelity® Total Market Index | 123.53K (0.66%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 14 | Vanguard US Total Market Shares ETF | 121.55K (0.65%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 15 | Fidelity® Series Total Market Index | 116.71K (0.62%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 16 | Invesco Dorsey Wright SmallCap Momt ETF | 104.73K (0.56%) | 136.00 Increased by +0.13% | Aug 29, 25 |
| 17 | Fidelity Advisor Biotechnology I | 103.90K (0.55%) | 52.00K Increased by +50.05% | Jul 31, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx SL Cl I | 93.02K (0.50%) | 72.02K Increased by +77.43% | Jul 31, 25 |
| 19 | Fidelity Extended Market Index | 80.48K (0.43%) | 678.00 Increased by +0.84% | Jul 31, 25 |
| 20 | Vanguard Russell 2000 ETF | 80.09K (0.43%) | -5.56K Decreased by -6.94% | Jul 31, 25 |