| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Wellington Management Company LLP | 12.72M (15.29%) | 3.43M Increased by +26.97% | Dec 31, 25 |
| 2 | venBio Select Advisor LLC | 12.22M (14.69%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 3 | EcoR1 Capital, LLC | 11.90M (14.29%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Vanguard Group Inc | 10.67M (12.83%) | 687.47K Increased by +6.44% | Dec 31, 25 |
| 5 | Morgan Stanley - Brokerage Accounts | 9.17M (11.02%) | -470.24K Decreased by -5.13% | Dec 31, 25 |
| 6 | Deep Track Capital, LP | 7.75M (9.31%) | -250.38K Decreased by -3.23% | Dec 31, 25 |
| 7 | BlackRock Inc | 6.26M (7.52%) | -8.35K Decreased by -0.13% | Dec 31, 25 |
| 8 | UBS Group AG | 6.21M (7.46%) | 2.02M Increased by +32.55% | Mar 31, 26 |
| 9 | State Street Corp | 4.61M (5.54%) | 575.80K Increased by +12.48% | Dec 31, 25 |
| 10 | Polar Capital Holdings PLC | 3.71M (4.45%) | 1.06M Increased by +28.50% | Dec 31, 25 |
| 11 | RTW INVESTMENTS, LLC | 3.69M (4.43%) | -3.98M Decreased by -108.05% | Mar 31, 26 |
| 12 | Suvretta Capital Management, LLC | 3.52M (4.23%) | -620.96K Decreased by -17.65% | Mar 31, 26 |
| 13 | T. Rowe Price Investment Management,Inc. | 2.99M (3.59%) | -1.06M Decreased by -35.61% | Sep 30, 24 |
| 14 | State Street Corporation | 2.91M (3.50%) | -5.89K Decreased by -0.20% | Mar 31, 24 |
| 15 | Siren, L.L.C. | 2.58M (3.10%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 16 | Orbimed Advisors, LLC | 2.43M (2.92%) | 106.50K Increased by +4.38% | Dec 31, 25 |
| 17 | AQR Capital Management LLC | 2.28M (2.74%) | -2.21M Decreased by -97.10% | Dec 31, 25 |
| 18 | Assenagon Asset Management SA | 2.14M (2.58%) | 1.41M Increased by +65.74% | Sep 30, 24 |
| 19 | Octagon Capital Advisors LP | 2.09M (2.52%) | -912.98K Decreased by -43.60% | Mar 31, 25 |
| 20 | Slate Path Capital LP | 2.07M (2.48%) | 2.07M Increased by +100.00% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 8.15M (9.80%) | 1.82M Increased by +22.34% | Dec 31, 25 |
| 2 | iShares Core S&P Small-Cap ETF | 6.25M (7.51%) | 1.34K Increased by +0.02% | Apr 30, 26 |
| 3 | Polar Capital Biotech S Inc | 4.00M (4.81%) | 250.00K Increased by +6.25% | Feb 28, 26 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 3.79M (4.55%) | -26.90K Decreased by -0.71% | Apr 30, 26 |
| 5 | Vanguard Total Stock Mkt Idx Inv | 3.42M (4.12%) | 22.34K Increased by +0.65% | Mar 31, 26 |
| 6 | Vanguard US Total Market Shares ETF | 3.30M (3.97%) | 2.68K Increased by +0.08% | Sep 30, 24 |
| 7 | Vanguard Small Cap Index | 2.51M (3.02%) | 69.48K Increased by +2.77% | Mar 31, 26 |
| 8 | US Small-Cap Growth II Equity Comp | 1.79M (2.15%) | 1.79M Increased by +100.00% | Jun 30, 23 |
| 9 | SPDR® S&P Biotech ETF | 1.76M (2.11%) | 3.92K Increased by +0.22% | Aug 31, 25 |
| 10 | Vanguard Explorer Inv | 1.75M (2.10%) | 753.63K Increased by +43.08% | Dec 31, 25 |
| 11 | Worldwide Healthcare Ord | 1.51M (1.81%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 12 | Vanguard Small Cap Growth Index Inv | 1.41M (1.69%) | 48.70K Increased by +3.46% | Mar 31, 26 |
| 13 | DWS Vermögensbildungsfonds I LD | 1.32M (1.59%) | 1.00 Increased by +0.00% | Mar 31, 26 |
| 14 | JPM US Mid Cap Growth-Composite | 1.30M (1.57%) | 294.66K Increased by +22.62% | Sep 30, 24 |
| 15 | JPMorgan Mid Cap Growth I | 1.30M (1.57%) | 0.00 Increased by 0.00% | Oct 31, 24 |
| 16 | T. Rowe Price Health Sciences | 1.29M (1.55%) | -29.49K Decreased by -2.28% | Mar 31, 24 |
| 17 | Fidelity® Select Biotechnology | 1.28M (1.54%) | 56.40K Increased by +4.41% | Nov 30, 23 |
| 18 | T. Rowe Price US Mid-Cap Growth Equity | 1.20M (1.44%) | -145.16K Decreased by -12.13% | Sep 30, 24 |
| 19 | Vanguard Institutional Extnd Mkt Idx Tr | 1.15M (1.38%) | 30.14K Increased by +2.63% | Mar 31, 26 |
| 20 | T. Rowe Price Small-Cap Stock | 1.09M (1.31%) | -1.60K Decreased by -0.15% | Dec 31, 23 |