| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 8.92M (9.83%) | 1.34K Increased by +0.02% | Dec 31, 25 |
| 2 | venBio Select Advisor LLC | 5.78M (6.37%) | 353.33K Increased by +6.12% | Mar 31, 26 |
| 3 | BlackRock Inc | 5.10M (5.62%) | 329.33K Increased by +6.46% | Dec 31, 25 |
| 4 | Wellington Management Company LLP | 4.76M (5.25%) | 1.15M Increased by +24.24% | Dec 31, 25 |
| 5 | Driehaus Capital Management LLC | 4.54M (5.00%) | 369.58K Increased by +8.14% | Dec 31, 25 |
| 6 | HHG PLC | 4.08M (4.50%) | 140.15K Increased by +3.43% | Dec 31, 25 |
| 7 | Capital Research & Mgmt Co - Division 3 | 2.67M (2.95%) | -740.23K Decreased by -27.68% | Mar 31, 26 |
| 8 | Polar Capital Holdings PLC | 2.47M (2.72%) | -81.07K Decreased by -3.29% | Dec 31, 25 |
| 9 | Capital World Investors | 2.22M (2.45%) | -69.82K Decreased by -3.14% | Mar 31, 25 |
| 10 | Paradigm Biocapital Advisors LP | 2.04M (2.25%) | -441.59K Decreased by -21.61% | Jun 30, 24 |
| 11 | Vestal Point Capital LP | 2.00M (2.20%) | 700.00K Increased by +35.00% | Jun 30, 25 |
| 12 | JPMorgan Chase & Co | 1.92M (2.12%) | 429.58K Increased by +22.33% | Mar 31, 26 |
| 13 | Bvf Inc | 1.83M (2.01%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 14 | BRAIDWELL LP | 1.83M (2.01%) | -1.78M Decreased by -97.53% | Dec 31, 25 |
| 15 | COMMODORE CAPITAL LP | 1.80M (1.98%) | -900.00K Decreased by -50.00% | Dec 31, 25 |
| 16 | AllianceBernstein L.P. | 1.59M (1.76%) | -60.60K Decreased by -3.80% | Dec 31, 25 |
| 17 | State Street Corp | 1.49M (1.64%) | 26.08K Increased by +1.75% | Dec 31, 25 |
| 18 | Pictet Asset Manangement SA | 1.47M (1.62%) | -3.17K Decreased by -0.21% | Jun 30, 25 |
| 19 | T. Rowe Price Investment Management,Inc. | 1.44M (1.58%) | -65.98K Decreased by -4.59% | Dec 31, 24 |
| 20 | Westfield Capital Management Company, L.P. | 1.40M (1.54%) | 174.71K Increased by +12.47% | Mar 31, 26 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 3.50M (3.86%) | -550.85K Decreased by -15.73% | Mar 31, 26 |
| 2 | Vanguard Health Care Inv | 3.21M (3.54%) | -127.83K Decreased by -3.98% | Mar 31, 26 |
| 3 | Strategic Advisers Fidelity US TtlStk | 2.99M (3.30%) | 952.00K Increased by +31.79% | Mar 31, 26 |
| 4 | Polar Capital Biotech S Inc | 2.41M (2.66%) | 1.66M Increased by +68.88% | Mar 31, 26 |
| 5 | iShares Russell 2000 ETF | 2.03M (2.24%) | 17.11K Increased by +0.84% | Apr 30, 26 |
| 6 | Polar Capital Healthcare Opports Inc | 1.54M (1.70%) | 636.25K Increased by +41.21% | Mar 31, 26 |
| 7 | Fidelity Select Health Care | 1.20M (1.32%) | -90.00K Decreased by -7.50% | Mar 31, 26 |
| 8 | Fidelity Small Cap Index | 743.76K (0.82%) | 8.94K Increased by +1.20% | Feb 28, 26 |
| 9 | Fidelity Advisor Biotechnology I | 710.76K (0.78%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 10 | iShares Russell 2000 Growth ETF | 709.99K (0.78%) | 4.30K Increased by +0.61% | Apr 30, 26 |
| 11 | iShares Biotechnology ETF | 686.07K (0.76%) | 100.12K Increased by +14.59% | Apr 30, 26 |
| 12 | Pictet Biotech | 658.54K (0.73%) | 658.54K Increased by +100.00% | Mar 31, 24 |
| 13 | Pictet-Biotech P USD | 625.53K (0.69%) | 7.66K Increased by +1.22% | May 31, 25 |
| 14 | Fidelity Advisor Health Care I | 600.00K (0.66%) | -90.00K Decreased by -15.00% | Mar 31, 26 |
| 15 | Pictet-Global Megatrend Sel I USD | 555.58K (0.61%) | 124.77K Increased by +22.46% | May 31, 25 |
| 16 | Lord Abbett Developing Growth A | 544.23K (0.60%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 17 | Fidelity Stock Selector Small Cap | 532.78K (0.59%) | 4.90K Increased by +0.92% | Feb 28, 26 |
| 18 | State St Russell Sm/Mid Cp® Indx SL Cl I | 522.90K (0.58%) | 8.50K Increased by +1.63% | Apr 30, 26 |
| 19 | Federated Hermes Kaufmann Growth | 522.50K (0.58%) | 182.50K Increased by +34.93% | Mar 31, 26 |
| 20 | Federated Hermes Kaufmann R | 522.50K (0.58%) | 182.50K Increased by +34.93% | Mar 31, 26 |