| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 4.54M (12.26%) | 709.10K Increased by +15.61% | Jun 30, 25 |
| 2 | UBS Asset Mgmt Americas Inc | 4.36M (11.76%) | 2.98M Increased by +68.42% | Mar 31, 25 |
| 3 | RA Capital Management, LLC | 3.21M (8.65%) | 3.21M Increased by +100.00% | Mar 31, 25 |
| 4 | The Toronto-Dominion Bank | 3.19M (8.61%) | 1.44M Increased by +45.18% | Jun 30, 25 |
| 5 | Morgan Stanley - Brokerage Accounts | 2.48M (6.69%) | 1.62M Increased by +65.39% | Jun 30, 25 |
| 6 | BlackRock Inc | 2.41M (6.49%) | -18.22K Decreased by -0.76% | Jun 30, 25 |
| 7 | Jefferies Financial Group Inc | 2.20M (5.93%) | 1.38M Increased by +62.95% | Jun 30, 25 |
| 8 | Soleus Capital Management, L.P. | 2.19M (5.89%) | 2.19M Increased by +100.00% | Jun 30, 25 |
| 9 | Vestal Point Capital LP | 2.15M (5.81%) | 522.96K Increased by +24.29% | Mar 31, 25 |
| 10 | SILVERARC CAPITAL MANAGEMENT, LLC | 2.02M (5.46%) | 641.32K Increased by +31.71% | Jun 30, 25 |
| 11 | Nantahala Capital Management, LLC | 1.36M (3.68%) | -8.24K Decreased by -0.60% | Mar 31, 25 |
| 12 | UBS Group AG | 1.17M (3.16%) | 250.39K Increased by +21.34% | Mar 31, 25 |
| 13 | MENORA MIVTACHIM HOLDINGS LIMITED | 1.15M (3.11%) | -1.15M Decreased by -99.82% | Jun 30, 25 |
| 14 | SG Americas Securities, LLC | 1.15M (3.10%) | 986.57K Increased by +85.86% | Jun 30, 25 |
| 15 | TANG CAPITAL MANAGEMENT LLC | 1.00M (2.70%) | 1.00M Increased by +100.00% | Jun 30, 25 |
| 16 | Adage Capital Partners Gp LLC | 830.00K (2.24%) | -447.00K Decreased by -53.86% | Jun 30, 25 |
| 17 | State Street Corp | 807.64K (2.18%) | 12.63K Increased by +1.56% | Jun 30, 25 |
| 18 | Migdal Insurance & Financial Holdings Ltd | 770.91K (2.08%) | -15.56K Decreased by -2.02% | Jun 30, 25 |
| 19 | Kynam Capital Management, LP | 656.57K (1.77%) | 631.57K Increased by +96.19% | Jun 30, 25 |
| 20 | Millennium Management LLC | 594.03K (1.60%) | 170.45K Increased by +28.69% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 4.69M (12.67%) | 4.69M Increased by +100.00% | Dec 31, 24 |
| 2 | UBS (Lux) Digital Health Equity SB USD | 1.32M (3.56%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 3 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 1.25M (3.37%) | 0.00 Increased by 0.00% | May 31, 25 |
| 4 | CS (Lux) Digital Health Equity SB USD | 1.20M (3.24%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 5 | iShares Russell 2000 ETF | 887.92K (2.40%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 6 | International Biotechnology Ord | 427.15K (1.15%) | -34.85K Decreased by -8.16% | May 31, 25 |
| 7 | MEDICAL BioHealth EUR Acc | 421.71K (1.14%) | 127.00K Increased by +30.12% | Aug 31, 24 |
| 8 | Fidelity Small Cap Index | 369.83K (1.00%) | -17.56K Decreased by -4.75% | Jun 30, 25 |
| 9 | iShares Russell 2000 Growth ETF | 264.63K (0.71%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 10 | State St Russell Sm/Mid Cp® Indx NL Cl C | 262.40K (0.71%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 11 | State St Russell Sm/Mid Cp® Indx SL Cl I | 262.40K (0.71%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 12 | iShares Biotechnology ETF | 233.34K (0.63%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 13 | Nuveen Quant Small Cap Equity R6 | 196.30K (0.53%) | 196.30K Increased by +100.00% | Jul 31, 25 |
| 14 | Fidelity® Small Cap Index | 189.44K (0.51%) | 5.40K Increased by +2.85% | Oct 31, 23 |
| 15 | Vanguard Russell 2000 ETF | 175.92K (0.47%) | -11.93K Decreased by -6.78% | Jul 31, 25 |
| 16 | SPDR® Portfolio Developed Wld ex-US ETF | 163.19K (0.44%) | 0.00 Increased by 0.00% | Aug 29, 25 |
| 17 | AlphaCentric LifeSci Healthcare I | 143.90K (0.39%) | -11.10K Decreased by -7.72% | Mar 31, 24 |
| 18 | State St Russell Sm Cap® Indx SL Cl I | 134.50K (0.36%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 19 | ARK Israel Innovative Technology ETF | 129.01K (0.35%) | 0.00 Increased by 0.00% | Aug 28, 25 |
| 20 | APO Medical Opportunities R | 98.89K (0.27%) | -78.50K Decreased by -79.38% | Sep 30, 24 |