| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 4.54M (10.52%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 2 | UBS Asset Mgmt Americas Inc | 4.36M (10.09%) | 2.98M Increased by +68.42% | Mar 31, 25 |
| 3 | RA Capital Management, LLC | 3.21M (7.42%) | 3.21M Increased by +100.00% | Mar 31, 25 |
| 4 | BlackRock Inc | 2.85M (6.59%) | 244.56K Increased by +8.59% | Mar 31, 26 |
| 5 | The Toronto-Dominion Bank | 2.62M (6.06%) | 2.62M Increased by +100.00% | Mar 31, 26 |
| 6 | Morgan Stanley - Brokerage Accounts | 2.56M (5.93%) | -2.86K Decreased by -0.11% | Mar 31, 26 |
| 7 | Kynam Capital Management, LP | 2.25M (5.20%) | 2.25M Increased by +100.00% | Mar 31, 26 |
| 8 | Jefferies Financial Group Inc | 2.20M (5.09%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 9 | Vestal Point Capital LP | 2.15M (4.98%) | 522.96K Increased by +24.29% | Mar 31, 25 |
| 10 | Paradigm Biocapital Advisors LP | 1.70M (3.94%) | -2.77M Decreased by -162.55% | Mar 31, 26 |
| 11 | SG Americas Securities, LLC | 1.66M (3.84%) | 280.20K Increased by +16.90% | Mar 31, 26 |
| 12 | American Century Companies Inc | 1.64M (3.79%) | 278.76K Increased by +17.02% | Mar 31, 26 |
| 13 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.50M (3.48%) | -235.78K Decreased by -15.69% | Mar 31, 26 |
| 14 | Opaleye Management Inc | 1.43M (3.31%) | 1.16M Increased by +81.23% | Mar 31, 26 |
| 15 | Nantahala Capital Management, LLC | 1.36M (3.16%) | -8.24K Decreased by -0.60% | Mar 31, 25 |
| 16 | Frontier Capital Management CO Inc | 1.31M (3.04%) | 532.49K Increased by +40.52% | Mar 31, 26 |
| 17 | UBS Group AG | 1.17M (2.72%) | 250.39K Increased by +21.34% | Mar 31, 25 |
| 18 | MENORA MIVTACHIM HOLDINGS LIMITED | 1.15M (2.67%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 19 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1.13M (2.60%) | 1.13M Increased by +100.00% | Dec 31, 25 |
| 20 | JPMorgan Chase & Co | 1.07M (2.48%) | 678.73K Increased by +63.49% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 4.69M (10.87%) | 4.69M Increased by +100.00% | Dec 31, 24 |
| 2 | RTW Biotech Opportunities Ord | 1.36M (3.15%) | 1.36M Increased by +100.00% | Jun 30, 25 |
| 3 | UBS (Lux) Digital Health Equity SB USD | 1.32M (3.06%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 4 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 1.25M (2.89%) | 0.00 Increased by 0.00% | May 31, 25 |
| 5 | CS (Lux) Digital Health Equity SB USD | 1.20M (2.78%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 6 | iShares Russell 2000 ETF | 958.88K (2.22%) | 8.84K Increased by +0.92% | May 29, 26 |
| 7 | American Century Small Cap Growth Inv | 874.98K (2.03%) | 221.94K Increased by +25.37% | Mar 31, 26 |
| 8 | American Century U.S. Small Cap Growth | 874.98K (2.03%) | 221.94K Increased by +25.37% | Mar 31, 26 |
| 9 | Biotech Growth Ord | 536.83K (1.24%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 10 | International Biotechnology Ord | 427.15K (0.99%) | -34.85K Decreased by -8.16% | May 31, 25 |
| 11 | Fidelity Small Cap Index | 394.00K (0.91%) | 33.35K Increased by +8.47% | Mar 31, 26 |
| 12 | Xtrackers S&P 500 Swap ETF 1C | 335.32K (0.78%) | 200.82K Increased by +59.89% | Dec 31, 25 |
| 13 | T. Rowe Price Health Sciences | 298.70K (0.69%) | -160.35K Decreased by -53.68% | Jan 31, 26 |
| 14 | iShares Biotechnology ETF | 285.53K (0.66%) | 5.47K Increased by +1.92% | May 29, 26 |
| 15 | iShares Russell 2000 Growth ETF | 272.37K (0.63%) | -1.77K Decreased by -0.65% | May 29, 26 |
| 16 | State St Russell Sm/Mid Cp® Indx NL Cl C | 262.40K (0.61%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 262.40K (0.61%) | 0.00 Increased by 0.00% | May 31, 26 |
| 18 | Russell 2000 Equity Index Fund B | 222.92K (0.52%) | -15.69K Decreased by -7.04% | Dec 31, 25 |
| 19 | MEDICAL BioHealth EUR Acc | 209.84K (0.49%) | 25.14K Increased by +11.98% | Jan 31, 26 |
| 20 | Vanguard Russell 2000 ETF | 203.63K (0.47%) | 5.48K Increased by +2.69% | Apr 30, 26 |