| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 4.54M (10.52%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 2 | UBS Asset Mgmt Americas Inc | 4.36M (10.10%) | 2.98M Increased by +68.42% | Mar 31, 25 |
| 3 | RA Capital Management, LLC | 3.21M (7.43%) | 3.21M Increased by +100.00% | Mar 31, 25 |
| 4 | The Toronto-Dominion Bank | 3.19M (7.39%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 5 | BlackRock Inc | 2.60M (6.02%) | 19.72K Increased by +0.76% | Dec 31, 25 |
| 6 | Morgan Stanley - Brokerage Accounts | 2.56M (5.94%) | 34.45K Increased by +1.34% | Dec 31, 25 |
| 7 | Jefferies Financial Group Inc | 2.20M (5.09%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | Soleus Capital Management, L.P. | 2.19M (5.06%) | 2.19M Increased by +100.00% | Jun 30, 25 |
| 9 | Vestal Point Capital LP | 2.15M (4.99%) | 522.96K Increased by +24.29% | Mar 31, 25 |
| 10 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.74M (4.03%) | 161.54K Increased by +9.29% | Dec 31, 25 |
| 11 | Paradigm Biocapital Advisors LP | 1.70M (3.95%) | -2.77M Decreased by -162.55% | Mar 31, 26 |
| 12 | SG Americas Securities, LLC | 1.66M (3.84%) | 280.20K Increased by +16.90% | Mar 31, 26 |
| 13 | Nantahala Capital Management, LLC | 1.36M (3.16%) | -8.24K Decreased by -0.60% | Mar 31, 25 |
| 14 | American Century Companies Inc | 1.36M (3.15%) | 1.36M Increased by +100.00% | Dec 31, 25 |
| 15 | Frontier Capital Management CO Inc | 1.31M (3.04%) | 532.49K Increased by +40.52% | Mar 31, 26 |
| 16 | UBS Group AG | 1.17M (2.72%) | 250.39K Increased by +21.34% | Mar 31, 25 |
| 17 | MENORA MIVTACHIM HOLDINGS LIMITED | 1.15M (2.67%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 18 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1.13M (2.61%) | 1.13M Increased by +100.00% | Dec 31, 25 |
| 19 | JPMorgan Chase & Co | 1.07M (2.48%) | 678.73K Increased by +63.49% | Sep 30, 25 |
| 20 | TANG CAPITAL MANAGEMENT LLC | 1.00M (2.32%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 4.69M (10.87%) | 4.69M Increased by +100.00% | Dec 31, 24 |
| 2 | RTW Biotech Opportunities Ord | 1.36M (3.15%) | 1.36M Increased by +100.00% | Jun 30, 25 |
| 3 | UBS (Lux) Digital Health Equity SB USD | 1.32M (3.06%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 4 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 1.25M (2.89%) | 0.00 Increased by 0.00% | May 31, 25 |
| 5 | CS (Lux) Digital Health Equity SB USD | 1.20M (2.78%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 6 | iShares Russell 2000 ETF | 949.88K (2.20%) | 7.99K Increased by +0.84% | Apr 30, 26 |
| 7 | American Century Small Cap Growth Inv | 874.98K (2.03%) | 221.94K Increased by +25.37% | Mar 31, 26 |
| 8 | American Century U.S. Small Cap Growth | 874.98K (2.03%) | 221.94K Increased by +25.37% | Mar 31, 26 |
| 9 | Biotech Growth Ord | 536.83K (1.24%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 10 | International Biotechnology Ord | 427.15K (0.99%) | -34.85K Decreased by -8.16% | May 31, 25 |
| 11 | Fidelity Small Cap Index | 360.64K (0.84%) | 3.68K Increased by +1.02% | Feb 28, 26 |
| 12 | Xtrackers S&P 500 Swap ETF 1C | 335.32K (0.78%) | 200.82K Increased by +59.89% | Dec 31, 25 |
| 13 | T. Rowe Price Health Sciences | 298.70K (0.69%) | -160.35K Decreased by -53.68% | Jan 31, 26 |
| 14 | iShares Biotechnology ETF | 285.22K (0.66%) | 5.12K Increased by +1.79% | Apr 30, 26 |
| 15 | iShares Russell 2000 Growth ETF | 270.57K (0.63%) | 698.00 Increased by +0.26% | Apr 30, 26 |
| 16 | State St Russell Sm/Mid Cp® Indx NL Cl C | 262.40K (0.61%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 262.40K (0.61%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 18 | Russell 2000 Equity Index Fund B | 222.92K (0.52%) | -15.69K Decreased by -7.04% | Dec 31, 25 |
| 19 | MEDICAL BioHealth EUR Acc | 209.84K (0.49%) | 25.14K Increased by +11.98% | Jan 31, 26 |
| 20 | Vanguard Russell 2000 ETF | 198.15K (0.46%) | 15.23K Increased by +7.69% | Mar 31, 26 |