| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 5.99M (13.66%) | 62.87K Increased by +1.05% | Sep 30, 25 |
| 2 | FMR Inc | 5.60M (12.78%) | -1.26M Decreased by -22.57% | Dec 31, 25 |
| 3 | RTW INVESTMENTS, LLC | 5.55M (12.66%) | 423.33K Increased by +7.63% | Dec 31, 25 |
| 4 | Lynx1 Capital Management, LP | 5.40M (12.33%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 5 | Redmile Group, LLC | 4.03M (9.20%) | -141.47K Decreased by -3.51% | Dec 31, 25 |
| 6 | Morgan Stanley - Brokerage Accounts | 3.54M (8.07%) | -36.93K Decreased by -1.04% | Sep 30, 25 |
| 7 | Baker Bros Advisors LP | 3.34M (7.61%) | -1.30M Decreased by -38.88% | Dec 31, 25 |
| 8 | COWEN AND COMPANY, LLC | 3.24M (7.40%) | -121.25K Decreased by -3.74% | Sep 30, 24 |
| 9 | The Toronto-Dominion Bank | 3.17M (7.24%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 10 | Vanguard Group Inc | 3.15M (7.18%) | -14.63K Decreased by -0.46% | Dec 31, 25 |
| 11 | Marshall Wace Asset Management Ltd | 2.30M (5.25%) | 168.77K Increased by +7.34% | Jun 30, 25 |
| 12 | Bvf Inc | 2.27M (5.17%) | 608.58K Increased by +26.86% | Dec 31, 25 |
| 13 | Skorpios Trust | 2.26M (5.15%) | -1.00M Decreased by -44.32% | Sep 30, 25 |
| 14 | Siren, L.L.C. | 2.25M (5.13%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 15 | Logos Global Management LP | 2.10M (4.79%) | 2.10M Increased by +100.00% | Jun 30, 24 |
| 16 | Deerfield Management Co | 1.82M (4.16%) | 1.82M Increased by +100.00% | Dec 31, 25 |
| 17 | State Street Corp | 1.43M (3.25%) | -61.28K Decreased by -4.30% | Sep 30, 25 |
| 18 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1.39M (3.16%) | 1.12M Increased by +80.99% | Jun 30, 24 |
| 19 | Goldman Sachs Group Inc | 1.30M (2.97%) | -360.66K Decreased by -27.71% | Jun 30, 25 |
| 20 | Polar Capital Holdings PLC | 1.27M (2.90%) | -54.34K Decreased by -4.28% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.71M (3.90%) | 14.72K Increased by +0.86% | Feb 28, 26 |
| 2 | Vanguard US Total Market Shares ETF | 1.61M (3.67%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | iShares Russell 2000 ETF | 1.19M (2.71%) | -9.68K Decreased by -0.82% | Mar 31, 26 |
| 4 | Polar Capital Biotech S Inc | 1.19M (2.71%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 5 | State Street® SPDR® S&P® Biotech ETF | 1.13M (2.57%) | 16.94K Increased by +1.50% | Mar 31, 26 |
| 6 | BGF World Healthscience A2 USD | 851.11K (1.94%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 7 | Fidelity Select Biotechnology | 792.59K (1.81%) | -147.90K Decreased by -18.66% | Feb 28, 26 |
| 8 | Fidelity Select Health Care | 750.00K (1.71%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 9 | SPDR® S&P Biotech ETF | 626.96K (1.43%) | 1.40K Increased by +0.22% | Aug 31, 25 |
| 10 | Vanguard Institutional Extnd Mkt Idx Tr | 559.71K (1.28%) | 3.98K Increased by +0.71% | Feb 28, 26 |
| 11 | Fidelity Stock Selector Small Cap | 532.90K (1.22%) | 17.20K Increased by +3.23% | Jan 31, 26 |
| 12 | Fidelity Small Cap Growth | 520.83K (1.19%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 13 | FIAM Small Cap Core Composite | 511.40K (1.17%) | -41.90K Decreased by -8.19% | Dec 31, 25 |
| 14 | HBM Healthcare Investments AG Ord | 495.85K (1.13%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 15 | BlackRock Health Sciences Opps Inv A | 473.15K (1.08%) | -3.54K Decreased by -0.75% | Feb 28, 26 |
| 16 | RTW Biotech Opportunities Ord | 457.19K (1.04%) | 457.19K Increased by +100.00% | Jun 30, 25 |
| 17 | FIAM Small Cap Core CIT Cl B | 445.00K (1.02%) | -66.40K Decreased by -14.92% | Jan 31, 26 |
| 18 | Fidelity Small Cap Index | 434.00K (0.99%) | -6.01K Decreased by -1.38% | Jan 31, 26 |
| 19 | Fidelity Series Small Cap Opps | 418.60K (0.96%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 20 | M&G (ACS) Granahan US Sm Cp Gr GBPZ1AAcc | 414.93K (0.95%) | 14.31K Increased by +3.45% | Jan 31, 24 |