| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 7.41M (17.71%) | 4.87M Increased by +65.71% | Jun 30, 25 |
| 2 | BlackRock Inc | 5.92M (14.15%) | 62.13K Increased by +1.05% | Jun 30, 25 |
| 3 | RTW INVESTMENTS, LLC | 5.12M (12.24%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Baker Bros Advisors LP | 4.63M (11.07%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 5 | Redmile Group, LLC | 4.38M (10.45%) | -110.05K Decreased by -2.51% | Jun 30, 25 |
| 6 | Morgan Stanley - Brokerage Accounts | 3.57M (8.54%) | -16.85K Decreased by -0.47% | Jun 30, 25 |
| 7 | Skorpios Trust | 3.26M (7.78%) | -3.65M Decreased by -112.09% | Jun 30, 25 |
| 8 | COWEN AND COMPANY, LLC | 3.24M (7.75%) | -121.25K Decreased by -3.74% | Sep 30, 24 |
| 9 | The Toronto-Dominion Bank | 3.17M (7.58%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 10 | Vanguard Group Inc | 2.95M (7.04%) | 162.06K Increased by +5.50% | Jun 30, 25 |
| 11 | Marshall Wace Asset Management Ltd | 2.30M (5.50%) | 168.77K Increased by +7.34% | Jun 30, 25 |
| 12 | Siren, L.L.C. | 2.25M (5.37%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 13 | Logos Global Management LP | 2.10M (5.02%) | 2.10M Increased by +100.00% | Jun 30, 24 |
| 14 | State Street Corp | 1.49M (3.55%) | -88.13K Decreased by -5.93% | Jun 30, 25 |
| 15 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1.39M (3.31%) | 1.12M Increased by +80.99% | Jun 30, 24 |
| 16 | Goldman Sachs Group Inc | 1.30M (3.11%) | -360.66K Decreased by -27.71% | Jun 30, 25 |
| 17 | Franklin Resources Inc | 1.22M (2.91%) | 157.90K Increased by +12.98% | Jun 30, 24 |
| 18 | Geode Capital Management, LLC | 972.92K (2.32%) | 70.94K Increased by +7.29% | Jun 30, 25 |
| 19 | Polar Capital Holdings PLC | 883.65K (2.11%) | 883.65K Increased by +100.00% | Jun 30, 25 |
| 20 | MPM Oncology Impact Management LP | 789.70K (1.89%) | 95.71K Increased by +12.12% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard US Total Market Shares ETF | 1.61M (3.84%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 2 | Fidelity Select Biotechnology | 1.57M (3.74%) | 330.59K Increased by +21.11% | Jul 31, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 1.54M (3.68%) | -34.18K Decreased by -2.22% | Jul 31, 25 |
| 4 | Polar Capital Biotech S Inc | 1.25M (2.99%) | 366.35K Increased by +29.31% | Jul 31, 25 |
| 5 | Fidelity Select Health Care | 1.20M (2.87%) | 200.00K Increased by +16.67% | Jul 31, 25 |
| 6 | iShares Russell 2000 ETF | 992.23K (2.37%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 7 | Fidelity Stock Selector Small Cap | 972.10K (2.32%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 8 | FIAM Small Cap Core CIT Cl B | 871.00K (2.08%) | 871.00K Increased by +100.00% | Jun 30, 25 |
| 9 | BlackRock Health Sciences Opps Inv A | 857.19K (2.05%) | -68.75K Decreased by -8.02% | Jul 31, 25 |
| 10 | BGF World Healthscience A2 | 851.11K (2.03%) | 0.00 Increased by 0.00% | May 31, 25 |
| 11 | BGF World Healthscience A2 USD | 851.11K (2.03%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 12 | Fidelity Series Small Cap Opps | 836.30K (2.00%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 13 | Fidelity Advisor Biotechnology I | 711.70K (1.70%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 14 | Fidelity Advisor Health Care I | 690.00K (1.65%) | 90.00K Increased by +13.04% | Jul 31, 25 |
| 15 | SPDR® S&P Biotech ETF | 626.96K (1.50%) | 1.40K Increased by +0.22% | Aug 31, 25 |
| 16 | HBM Healthcare Investments AG Ord | 495.85K (1.18%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 17 | Vanguard Institutional Extnd Mkt Idx Tr | 437.94K (1.05%) | -184.79K Decreased by -42.19% | Jul 31, 25 |
| 18 | M&G (ACS) Granahan US Sm Cp Gr GBPZ1AAcc | 414.93K (0.99%) | 14.31K Increased by +3.45% | Jan 31, 24 |
| 19 | Fidelity Small Cap Index | 412.52K (0.99%) | 46.23K Increased by +11.21% | Jun 30, 25 |
| 20 | iShares Russell 2000 Growth ETF | 356.62K (0.85%) | 0.00 Increased by 0.00% | Aug 31, 25 |