| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HHG PLC | 5.14M (13.43%) | -47.37K Decreased by -0.92% | Mar 31, 25 |
| 2 | Vivo Capital, LLC | 4.46M (11.65%) | -1.83M Decreased by -41.13% | Mar 31, 25 |
| 3 | Adage Capital Partners Gp LLC | 4.39M (11.47%) | 1.62M Increased by +36.80% | Mar 31, 25 |
| 4 | venBio Select Advisor LLC | 2.52M (6.60%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | T. Rowe Price Associates, Inc. | 2.40M (6.27%) | 769.70K Increased by +32.07% | Mar 31, 25 |
| 6 | FMR Inc | 2.23M (5.83%) | 1.42M Increased by +63.60% | Mar 31, 25 |
| 7 | BlackRock Inc | 1.91M (5.00%) | -96.46K Decreased by -5.04% | Mar 31, 25 |
| 8 | Vanguard Group Inc | 1.87M (4.88%) | -18.21K Decreased by -0.98% | Mar 31, 25 |
| 9 | Nantahala Capital Management, LLC | 1.76M (4.59%) | -2.17M Decreased by -123.61% | Mar 31, 25 |
| 10 | Citadel Advisors Llc | 1.58M (4.12%) | 603.63K Increased by +38.30% | Mar 31, 25 |
| 11 | Perceptive Advisors LLC | 1.51M (3.94%) | 5.56K Increased by +0.37% | Mar 31, 25 |
| 12 | RA Capital Management, LLC | 1.24M (3.24%) | 1.24M Increased by +100.00% | Sep 30, 23 |
| 13 | Westfield Capital Management Company, L.P. | 1.21M (3.16%) | 329.79K Increased by +27.23% | Mar 31, 25 |
| 14 | Holocene Advisors, LP | 1.20M (3.13%) | 241.52K Increased by +20.18% | Mar 31, 25 |
| 15 | State Street Corp | 1.17M (3.05%) | -177.82K Decreased by -15.21% | Mar 31, 25 |
| 16 | COMMODORE CAPITAL LP | 1.15M (3.00%) | -375.00K Decreased by -32.61% | Mar 31, 25 |
| 17 | Fairmount Funds Management LLC | 1.14M (2.98%) | 1.14M Increased by +100.00% | Sep 30, 23 |
| 18 | Vestal Point Capital LP | 1.06M (2.77%) | 340.00K Increased by +32.08% | Dec 31, 24 |
| 19 | Alyeska Investment Group, L.P. | 976.11K (2.55%) | 976.11K Increased by +100.00% | Sep 30, 24 |
| 20 | State Street Corporation | 970.57K (2.54%) | 469.17K Increased by +48.34% | Mar 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.14M (2.97%) | 3.49K Increased by +0.31% | Apr 30, 25 |
| 2 | Janus Henderson Global Life Sciences | 923.65K (2.41%) | -9.65K Decreased by -1.04% | Mar 31, 25 |
| 3 | Janus Henderson Global Life Sciences D | 923.65K (2.41%) | -3.42K Decreased by -0.37% | Mar 31, 25 |
| 4 | Vanguard US Total Market Shares ETF | 913.59K (2.39%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | Polar Capital Biotech S Inc | 750.00K (1.96%) | 250.00K Increased by +33.33% | Apr 30, 25 |
| 6 | Janus Global Life Science AUSD | 749.01K (1.96%) | 10.14K Increased by +1.35% | Mar 31, 25 |
| 7 | Janus Henderson Glb Life Scn I2 USD | 744.52K (1.94%) | -4.49K Decreased by -0.60% | Apr 30, 25 |
| 8 | T. Rowe Price All-Cap Opportunities Fund | 732.72K (1.91%) | 365.30K Increased by +49.86% | Mar 31, 25 |
| 9 | T. Rowe Price US All-Cap Opp Eq Comp | 732.72K (1.91%) | 397.00K Increased by +54.18% | Mar 31, 25 |
| 10 | iShares Russell 2000 ETF | 640.20K (1.67%) | 0.00 Increased by 0.00% | May 31, 25 |
| 11 | SPDR® S&P Biotech ETF | 533.46K (1.39%) | 3.15K Increased by +0.59% | May 31, 25 |
| 12 | American Funds SMALLCAP World A | 464.83K (1.21%) | 464.83K Increased by +100.00% | Mar 31, 25 |
| 13 | Janus Henderson US SMID Cap Growth MA | 457.55K (1.20%) | 457.52K Increased by +99.99% | Dec 31, 24 |
| 14 | T. Rowe Price Health Sciences | 451.65K (1.18%) | 276.70K Increased by +61.26% | Mar 31, 25 |
| 15 | Janus Henderson Triton D | 450.38K (1.18%) | -4.69K Decreased by -1.04% | Mar 31, 25 |
| 16 | Janus Henderson US SMID Cap Growth | 450.38K (1.18%) | -7.17K Decreased by -1.59% | Mar 31, 25 |
| 17 | MEDICAL BioHealth EUR Acc | 443.03K (1.16%) | 60.00K Increased by +13.54% | Jan 31, 25 |
| 18 | Pictet-Biotech P USD | 440.39K (1.15%) | -7.50K Decreased by -1.70% | Apr 30, 25 |
| 19 | Janus Selection Global Life Science AUSD | 418.61K (1.09%) | 32.45K Increased by +7.75% | Jun 30, 24 |
| 20 | T. Rowe Price New Horizons | 407.15K (1.06%) | -5.51K Decreased by -1.35% | Mar 31, 25 |