| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 8.08M (16.91%) | 79.62K Increased by +0.99% | Dec 31, 25 |
| 2 | HHG PLC | 6.06M (12.68%) | 748.33K Increased by +12.36% | Sep 30, 25 |
| 3 | T. Rowe Price Associates, Inc. | 3.90M (8.17%) | 441.42K Increased by +11.31% | Sep 30, 25 |
| 4 | Adage Capital Partners Gp LLC | 3.58M (7.49%) | -816.73K Decreased by -22.84% | Jun 30, 25 |
| 5 | BlackRock Inc | 3.49M (7.31%) | 647.50K Increased by +18.54% | Sep 30, 25 |
| 6 | Wellington Management Company LLP | 3.32M (6.96%) | 1.01M Increased by +30.42% | Dec 31, 25 |
| 7 | Vanguard Group Inc | 3.06M (6.41%) | 253.21K Increased by +8.27% | Dec 31, 25 |
| 8 | venBio Select Advisor LLC | 2.90M (6.07%) | 322.22K Increased by +11.11% | Dec 31, 25 |
| 9 | State Street Corp | 2.17M (4.55%) | 768.05K Increased by +35.34% | Sep 30, 25 |
| 10 | Perceptive Advisors LLC | 1.51M (3.15%) | 5.56K Increased by +0.37% | Mar 31, 25 |
| 11 | Citadel Advisors Llc | 1.51M (3.15%) | -70.88K Decreased by -4.71% | Jun 30, 25 |
| 12 | Amvescap Plc. | 1.50M (3.14%) | 854.55K Increased by +56.95% | Sep 30, 25 |
| 13 | Westfield Capital Management Company, L.P. | 1.43M (2.99%) | 218.51K Increased by +15.28% | Jun 30, 25 |
| 14 | Nantahala Capital Management, LLC | 1.31M (2.75%) | 450.24K Increased by +34.26% | Dec 31, 25 |
| 15 | RA Capital Management, LLC | 1.24M (2.59%) | 1.24M Increased by +100.00% | Sep 30, 23 |
| 16 | COMMODORE CAPITAL LP | 1.20M (2.51%) | -150.00K Decreased by -12.50% | Dec 31, 25 |
| 17 | Polar Capital Holdings PLC | 1.19M (2.49%) | 373.62K Increased by +31.37% | Sep 30, 25 |
| 18 | BRAIDWELL LP | 1.19M (2.49%) | -94.13K Decreased by -7.92% | Dec 31, 25 |
| 19 | Holocene Advisors, LP | 1.15M (2.41%) | -43.94K Decreased by -3.81% | Jun 30, 25 |
| 20 | Fairmount Funds Management LLC | 1.14M (2.39%) | 1.14M Increased by +100.00% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 1.98M (4.14%) | 718.19K Increased by +36.30% | Dec 31, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.63M (3.42%) | 4.78K Increased by +0.29% | Jan 31, 26 |
| 3 | State Street® SPDR® S&P® Biotech ETF | 1.59M (3.33%) | -56.07K Decreased by -3.52% | Feb 27, 26 |
| 4 | T. Rowe Price US All-Cap Opp Eq Comp | 1.32M (2.76%) | -132.50K Decreased by -10.04% | Dec 31, 25 |
| 5 | iShares Russell 2000 ETF | 1.14M (2.38%) | 1.14M Increased by +100.00% | Feb 28, 26 |
| 6 | Strategic Advisers Fidelity US TtlStk | 1.08M (2.25%) | 26.10K Increased by +2.43% | Jan 31, 26 |
| 7 | Polar Capital Biotech S Inc | 1.07M (2.25%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | Fidelity Advisor Growth Opps M | 1.04M (2.18%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 9 | Janus Henderson Global Life Sciences | 1.00M (2.10%) | -13.36K Decreased by -1.33% | Dec 31, 25 |
| 10 | Janus Henderson Global Life Sciences D | 1.00M (2.10%) | -5.50K Decreased by -0.55% | Dec 31, 25 |
| 11 | Fidelity OTC | 947.90K (1.98%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 12 | T. Rowe Price Health Sciences | 924.65K (1.94%) | 338.20K Increased by +36.58% | Jul 31, 25 |
| 13 | T. Rowe Price All-Cap Opportunities Fund | 923.47K (1.93%) | -396.77K Decreased by -42.97% | Jan 31, 26 |
| 14 | Vanguard US Total Market Shares ETF | 913.59K (1.91%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 15 | Janus Henderson Glb Life Scn I2 USD | 884.93K (1.85%) | 12.88K Increased by +1.45% | Jan 31, 26 |
| 16 | Janus Global Life Science AUSD | 872.05K (1.83%) | 26.25K Increased by +3.01% | Dec 31, 25 |
| 17 | Fidelity Select Health Care | 780.00K (1.63%) | 260.00K Increased by +33.33% | Jul 31, 25 |
| 18 | Janus Henderson Hrzn Biotec E2 USD | 699.20K (1.46%) | 357.36K Increased by +51.11% | Dec 31, 25 |
| 19 | Fidelity Small Cap Growth | 652.51K (1.37%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 20 | Janus Henderson Triton D | 629.64K (1.32%) | 159.83K Increased by +25.38% | Dec 31, 25 |