| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 16.72M (8.61%) | 1.06M Increased by +6.32% | Dec 31, 25 |
| 2 | Farallon Capital Management, L.L.C. | 14.58M (7.51%) | -42.90K Decreased by -0.29% | Dec 31, 25 |
| 3 | HHG PLC | 12.30M (6.34%) | 947.45K Increased by +7.70% | Dec 31, 25 |
| 4 | Baker Bros Advisors LP | 9.56M (4.92%) | 100.00K Increased by +1.05% | Mar 31, 26 |
| 5 | BlackRock Inc | 8.93M (4.60%) | 598.90K Increased by +6.71% | Dec 31, 25 |
| 6 | FMR Inc | 8.59M (4.42%) | -813.71K Decreased by -9.47% | Dec 31, 25 |
| 7 | Nextech Invest AG | 7.60M (3.91%) | 1.30M Increased by +17.16% | Dec 31, 24 |
| 8 | Nextech Invest, Ltd. | 7.60M (3.91%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | Wellington Management Company LLP | 6.99M (3.60%) | -2.83M Decreased by -40.44% | Dec 31, 25 |
| 10 | Paradigm Biocapital Advisors LP | 6.66M (3.43%) | 11.30K Increased by +0.17% | Mar 31, 26 |
| 11 | EcoR1 Capital, LLC | 5.58M (2.87%) | -1.62M Decreased by -29.06% | Sep 30, 23 |
| 12 | State Street Corporation | 5.39M (2.77%) | -867.34K Decreased by -16.10% | Mar 31, 24 |
| 13 | Bellevue Group AG | 5.01M (2.58%) | -568.12K Decreased by -11.35% | Dec 31, 25 |
| 14 | JPMorgan Chase & Co | 5.00M (2.57%) | 2.16M Increased by +43.22% | Sep 30, 25 |
| 15 | UBS Group AG | 4.39M (2.26%) | 1.30M Increased by +29.61% | Mar 31, 26 |
| 16 | Boxer Capital LLC | 4.28M (2.20%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 17 | Boxer Capital Management, LLC | 4.28M (2.20%) | 4.28M Increased by +100.00% | Dec 31, 24 |
| 18 | State Street Corp | 4.11M (2.12%) | -1.15M Decreased by -27.87% | Dec 31, 25 |
| 19 | Holocene Advisors, LP | 3.63M (1.87%) | -58.79K Decreased by -1.62% | Jun 30, 25 |
| 20 | T. Rowe Price Investment Management,Inc. | 3.50M (1.80%) | -1.28M Decreased by -36.61% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 5.98M (3.08%) | 148.91K Increased by +2.49% | Mar 31, 26 |
| 2 | Vanguard US Total Market Shares ETF | 4.74M (2.44%) | 4.24K Increased by +0.09% | Sep 30, 24 |
| 3 | BB Biotech AG Ord | 4.37M (2.25%) | -484.46K Decreased by -11.08% | Dec 31, 24 |
| 4 | Vanguard Small Cap Index | 4.35M (2.24%) | 175.10K Increased by +4.03% | Mar 31, 26 |
| 5 | iShares Russell 2000 ETF | 4.27M (2.20%) | 0.00 Increased by 0.00% | May 31, 25 |
| 6 | Fidelity Growth Compy Commingled Pl S | 3.39M (1.75%) | 4.51K Increased by +0.13% | Mar 31, 26 |
| 7 | Vanguard Health Care Inv | 2.58M (1.33%) | 191.45K Increased by +7.43% | Mar 31, 26 |
| 8 | Fidelity Growth Company Fund | 2.51M (1.29%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 9 | Vanguard Small Cap Growth Index Inv | 2.43M (1.25%) | 117.05K Increased by +4.81% | Mar 31, 26 |
| 10 | Janus Henderson Mid Cap Growth MA | 2.09M (1.07%) | 2.09M Increased by +100.00% | Sep 30, 25 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 2.03M (1.05%) | 50.97K Increased by +2.51% | Mar 31, 26 |
| 12 | SPDR® S&P Biotech ETF | 1.87M (0.96%) | 4.16K Increased by +0.22% | Aug 31, 25 |
| 13 | Fidelity Small Cap Index | 1.73M (0.89%) | 3.93K Increased by +0.23% | May 31, 25 |
| 14 | US Small-Cap Growth II Equity Comp | 1.66M (0.85%) | -539.14K Decreased by -32.51% | Jun 30, 25 |
| 15 | T. Rowe Price Health Sciences | 1.52M (0.78%) | -45.78K Decreased by -3.01% | Mar 31, 26 |
| 16 | T. Rowe Price US Mid-Cap Growth Equity | 1.50M (0.77%) | 1.50M Increased by +100.00% | Jun 30, 25 |
| 17 | T. Rowe Price Mid-Cap Growth | 1.50M (0.77%) | -2.70K Decreased by -0.18% | Jul 31, 25 |
| 18 | Fidelity Growth Compy Commingled Pl O | 1.44M (0.74%) | 16.60K Increased by +1.15% | Aug 31, 24 |
| 19 | Janus Henderson Enterprise D | 1.42M (0.73%) | -668.40K Decreased by -47.13% | Jan 31, 26 |
| 20 | T. Rowe Price New Horizons | 1.36M (0.70%) | -242.13K Decreased by -17.86% | Jun 30, 25 |