| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 15.76M (9.94%) | -850.34K Decreased by -5.40% | Jun 30, 25 |
| 2 | Farallon Capital Management, L.L.C. | 14.33M (9.04%) | 791.00K Increased by +5.52% | Jun 30, 25 |
| 3 | HHG PLC | 10.59M (6.68%) | 400.66K Increased by +3.78% | Jun 30, 25 |
| 4 | Wellington Management Company LLP | 10.26M (6.47%) | -1.53M Decreased by -14.89% | Jun 30, 25 |
| 5 | Baker Bros Advisors LP | 9.36M (5.91%) | 1.43M Increased by +15.25% | Jun 30, 25 |
| 6 | BlackRock Inc | 8.66M (5.46%) | -6.03M Decreased by -69.63% | Jun 30, 25 |
| 7 | FMR Inc | 8.33M (5.25%) | 789.41K Increased by +9.48% | Jun 30, 25 |
| 8 | Nextech Invest AG | 7.60M (4.79%) | 1.30M Increased by +17.16% | Dec 31, 24 |
| 9 | Nextech Invest, Ltd. | 7.60M (4.79%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 10 | Paradigm Biocapital Advisors LP | 6.09M (3.84%) | -84.82K Decreased by -1.39% | Jun 30, 25 |
| 11 | EcoR1 Capital, LLC | 5.58M (3.52%) | -1.62M Decreased by -29.06% | Sep 30, 23 |
| 12 | State Street Corporation | 5.39M (3.40%) | -867.34K Decreased by -16.10% | Mar 31, 24 |
| 13 | Bvf Inc | 4.98M (3.14%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 14 | State Street Corp | 4.72M (2.98%) | -1.09M Decreased by -23.01% | Jun 30, 25 |
| 15 | T. Rowe Price Associates, Inc. | 4.70M (2.97%) | -897.68K Decreased by -19.09% | Jun 30, 25 |
| 16 | T. Rowe Price Investment Management,Inc. | 4.69M (2.96%) | 3.02M Increased by +64.31% | Jun 30, 25 |
| 17 | Bellevue Group AG | 4.58M (2.89%) | 205.00K Increased by +4.48% | Jun 30, 25 |
| 18 | Boxer Capital LLC | 4.28M (2.70%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 19 | Boxer Capital Management, LLC | 4.28M (2.70%) | 4.28M Increased by +100.00% | Dec 31, 24 |
| 20 | Alphabet Inc | 4.13M (2.61%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 5.28M (3.33%) | -110.56K Decreased by -2.10% | Jul 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 4.74M (2.99%) | 4.24K Increased by +0.09% | Sep 30, 24 |
| 3 | BB Biotech AG Ord | 4.37M (2.76%) | -484.46K Decreased by -11.08% | Dec 31, 24 |
| 4 | iShares Russell 2000 ETF | 4.27M (2.69%) | 0.00 Increased by 0.00% | May 31, 25 |
| 5 | Vanguard Small Cap Index | 4.07M (2.57%) | -22.59K Decreased by -0.55% | Jul 31, 25 |
| 6 | Vanguard Health Care Inv | 3.87M (2.44%) | -946.03K Decreased by -24.42% | Jun 30, 25 |
| 7 | Fidelity Growth Compy Commingled Pl S | 3.27M (2.07%) | 207.40K Increased by +6.33% | Jul 31, 25 |
| 8 | Janus Henderson Enterprise D | 2.40M (1.52%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 9 | Janus Inst Mid Cap Growth CF | 2.40M (1.52%) | 377.18K Increased by +15.69% | Jun 30, 25 |
| 10 | Fidelity Growth Company Fund | 2.40M (1.51%) | 142.40K Increased by +5.94% | Jul 31, 25 |
| 11 | Vanguard Small Cap Growth Index Inv | 2.30M (1.45%) | -2.23K Decreased by -0.10% | Jul 31, 25 |
| 12 | Vanguard Institutional Extnd Mkt Idx Tr | 1.88M (1.19%) | -824.24K Decreased by -43.83% | Jul 31, 25 |
| 13 | SPDR® S&P Biotech ETF | 1.87M (1.18%) | 4.16K Increased by +0.22% | Aug 31, 25 |
| 14 | Fidelity Small Cap Index | 1.73M (1.09%) | 3.93K Increased by +0.23% | May 31, 25 |
| 15 | US Small-Cap Growth II Equity Comp | 1.66M (1.05%) | -539.14K Decreased by -32.51% | Jun 30, 25 |
| 16 | T. Rowe Price US Mid-Cap Growth Equity | 1.50M (0.95%) | 1.50M Increased by +100.00% | Jun 30, 25 |
| 17 | T. Rowe Price Mid-Cap Growth | 1.50M (0.94%) | -2.70K Decreased by -0.18% | Jul 31, 25 |
| 18 | Fidelity Growth Compy Commingled Pl O | 1.44M (0.91%) | 16.60K Increased by +1.15% | Aug 31, 24 |
| 19 | T. Rowe Price Health Sciences | 1.36M (0.86%) | -15.26K Decreased by -1.12% | Jul 31, 25 |
| 20 | T. Rowe Price New Horizons | 1.36M (0.86%) | -242.13K Decreased by -17.86% | Jun 30, 25 |