| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 17.10M (10.16%) | 2.19M Increased by +12.78% | Dec 31, 24 |
| 2 | BlackRock Inc | 14.72M (8.75%) | 852.69K Increased by +5.79% | Dec 31, 24 |
| 3 | Farallon Capital Management, L.L.C. | 13.25M (7.88%) | 1.93M Increased by +14.58% | Dec 31, 24 |
| 4 | Wellington Management Company LLP | 10.82M (6.43%) | -579.70K Decreased by -5.36% | Dec 31, 24 |
| 5 | HHG PLC | 9.48M (5.64%) | 3.35M Increased by +35.29% | Dec 31, 24 |
| 6 | Baker Bros Advisors LP | 7.94M (4.72%) | 367.88K Increased by +4.64% | Dec 31, 24 |
| 7 | Nextech Invest AG | 7.60M (4.52%) | 1.30M Increased by +17.16% | Dec 31, 24 |
| 8 | FMR Inc | 6.74M (4.01%) | 866.19K Increased by +12.85% | Dec 31, 24 |
| 9 | Paradigm Biocapital Advisors LP | 6.55M (3.90%) | 1.24M Increased by +18.91% | Dec 31, 24 |
| 10 | T. Rowe Price Associates, Inc. | 5.87M (3.49%) | 552.66K Increased by +9.42% | Dec 31, 24 |
| 11 | State Street Corp | 5.79M (3.44%) | 512.17K Increased by +8.84% | Dec 31, 24 |
| 12 | EcoR1 Capital, LLC | 5.58M (3.32%) | -1.62M Decreased by -29.06% | Sep 30, 23 |
| 13 | State Street Corporation | 5.39M (3.20%) | -867.34K Decreased by -16.10% | Mar 31, 24 |
| 14 | Bellevue Group AG | 4.39M (2.61%) | -484.46K Decreased by -11.04% | Dec 31, 24 |
| 15 | Boxer Capital LLC | 4.28M (2.54%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 16 | Boxer Capital Management, LLC | 4.28M (2.54%) | 4.28M Increased by +100.00% | Dec 31, 24 |
| 17 | Bvf Inc | 4.18M (2.49%) | 702.57K Increased by +16.80% | Dec 31, 24 |
| 18 | Alphabet Inc | 4.13M (2.46%) | -122.90K Decreased by -2.97% | Dec 31, 24 |
| 19 | Geode Capital Management, LLC | 4.09M (2.43%) | 459.17K Increased by +11.24% | Dec 31, 24 |
| 20 | Woodline Partners LP | 3.89M (2.31%) | 452.00K Increased by +11.63% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 5.47M (3.25%) | 3.66K Increased by +0.07% | Feb 28, 25 |
| 2 | iShares Russell 2000 ETF | 4.48M (2.66%) | -38.77K Decreased by -0.87% | Mar 31, 25 |
| 3 | Vanguard Small Cap Index | 4.42M (2.63%) | 3.64K Increased by +0.08% | Feb 28, 25 |
| 4 | BB Biotech AG Ord | 4.37M (2.60%) | -484.46K Decreased by -11.08% | Dec 31, 24 |
| 5 | Vanguard Health Care Inv | 4.30M (2.55%) | -1.19M Decreased by -27.60% | Dec 31, 24 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 2.61M (1.55%) | 3.70K Increased by +0.14% | Feb 28, 25 |
| 7 | Vanguard Small Cap Growth Index Inv | 2.48M (1.48%) | -13.58K Decreased by -0.55% | Feb 28, 25 |
| 8 | US Small-Cap Growth II Equity Comp | 2.22M (1.32%) | 95.29K Increased by +4.29% | Dec 31, 24 |
| 9 | Janus Henderson Enterprise D | 2.03M (1.20%) | 171.50K Increased by +8.46% | Jan 31, 25 |
| 10 | SPDR® S&P Biotech ETF | 2.00M (1.19%) | -21.46K Decreased by -1.07% | Mar 31, 25 |
| 11 | Fidelity Growth Compy Commingled Pl S | 1.98M (1.18%) | 327.02K Increased by +16.50% | Feb 28, 25 |
| 12 | T. Rowe Price New Horizons | 1.92M (1.14%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 13 | Janus Inst Mid Cap Growth CF | 1.86M (1.10%) | 1.86M Increased by +100.00% | Dec 31, 24 |
| 14 | T. Rowe Price Health Sciences | 1.73M (1.03%) | 91.90K Increased by +5.32% | Feb 28, 25 |
| 15 | Fidelity Small Cap Index | 1.65M (0.98%) | -30.92K Decreased by -1.87% | Jan 31, 25 |
| 16 | Fidelity Growth Compy Commingled Pl O | 1.44M (0.86%) | 16.60K Increased by +1.15% | Aug 31, 24 |
| 17 | Fidelity Growth Company Fund | 1.36M (0.81%) | 238.40K Increased by +17.49% | Feb 28, 25 |
| 18 | Janus Henderson Global Life Sciences | 1.33M (0.79%) | 158.37K Increased by +11.94% | Dec 31, 24 |
| 19 | Janus Henderson Global Life Sciences D | 1.31M (0.78%) | -21.06K Decreased by -1.61% | Jan 31, 25 |
| 20 | JPM Global Healthcare C (acc) USD | 1.24M (0.73%) | 0.00 Increased by 0.00% | Jan 31, 24 |