| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 16.72M (9.35%) | 1.06M Increased by +6.32% | Dec 31, 25 |
| 2 | Farallon Capital Management, L.L.C. | 14.58M (8.16%) | -42.90K Decreased by -0.29% | Dec 31, 25 |
| 3 | HHG PLC | 11.36M (6.35%) | 765.33K Increased by +6.74% | Sep 30, 25 |
| 4 | Baker Bros Advisors LP | 9.46M (5.29%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 5 | FMR Inc | 8.59M (4.80%) | -813.71K Decreased by -9.47% | Dec 31, 25 |
| 6 | BlackRock Inc | 8.33M (4.66%) | -333.63K Decreased by -4.01% | Sep 30, 25 |
| 7 | Nextech Invest AG | 7.60M (4.25%) | 1.30M Increased by +17.16% | Dec 31, 24 |
| 8 | Nextech Invest, Ltd. | 7.60M (4.25%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | Wellington Management Company LLP | 6.99M (3.91%) | -2.83M Decreased by -40.44% | Dec 31, 25 |
| 10 | Paradigm Biocapital Advisors LP | 6.64M (3.72%) | 421.11K Increased by +6.34% | Dec 31, 25 |
| 11 | EcoR1 Capital, LLC | 5.58M (3.12%) | -1.62M Decreased by -29.06% | Sep 30, 23 |
| 12 | State Street Corporation | 5.39M (3.01%) | -867.34K Decreased by -16.10% | Mar 31, 24 |
| 13 | State Street Corp | 5.25M (2.94%) | 535.73K Increased by +10.20% | Sep 30, 25 |
| 14 | Bellevue Group AG | 5.01M (2.80%) | -568.12K Decreased by -11.35% | Dec 31, 25 |
| 15 | JPMorgan Chase & Co | 5.00M (2.80%) | 2.16M Increased by +43.22% | Sep 30, 25 |
| 16 | Boxer Capital LLC | 4.28M (2.39%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 17 | Boxer Capital Management, LLC | 4.28M (2.39%) | 4.28M Increased by +100.00% | Dec 31, 24 |
| 18 | Alphabet Inc | 4.13M (2.31%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 19 | T. Rowe Price Associates, Inc. | 3.87M (2.17%) | -828.26K Decreased by -21.38% | Sep 30, 25 |
| 20 | Holocene Advisors, LP | 3.63M (2.03%) | -58.79K Decreased by -1.62% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 5.84M (3.27%) | 10.07K Increased by +0.17% | Feb 28, 26 |
| 2 | Vanguard US Total Market Shares ETF | 4.74M (2.65%) | 4.24K Increased by +0.09% | Sep 30, 24 |
| 3 | BB Biotech AG Ord | 4.37M (2.45%) | -484.46K Decreased by -11.08% | Dec 31, 24 |
| 4 | iShares Russell 2000 ETF | 4.27M (2.39%) | 0.00 Increased by 0.00% | May 31, 25 |
| 5 | Vanguard Small Cap Index | 4.17M (2.33%) | 10.92K Increased by +0.26% | Feb 28, 26 |
| 6 | Fidelity Growth Compy Commingled Pl S | 3.39M (1.90%) | -70.00K Decreased by -2.07% | Feb 28, 26 |
| 7 | Fidelity Growth Company Fund | 2.51M (1.40%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 8 | Vanguard Health Care Inv | 2.38M (1.33%) | -1.25M Decreased by -52.55% | Dec 31, 25 |
| 9 | Vanguard Small Cap Growth Index Inv | 2.32M (1.30%) | 4.73K Increased by +0.20% | Feb 28, 26 |
| 10 | Janus Henderson Mid Cap Growth MA | 2.09M (1.17%) | 2.09M Increased by +100.00% | Sep 30, 25 |
| 11 | Janus Inst Mid Cap Growth CF | 2.09M (1.17%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | Vanguard Institutional Extnd Mkt Idx Tr | 1.98M (1.11%) | 18.40K Increased by +0.93% | Feb 28, 26 |
| 13 | SPDR® S&P Biotech ETF | 1.87M (1.04%) | 4.16K Increased by +0.22% | Aug 31, 25 |
| 14 | Fidelity Small Cap Index | 1.73M (0.97%) | 3.93K Increased by +0.23% | May 31, 25 |
| 15 | US Small-Cap Growth II Equity Comp | 1.66M (0.93%) | -539.14K Decreased by -32.51% | Jun 30, 25 |
| 16 | T. Rowe Price Health Sciences | 1.52M (0.85%) | 91.12K Increased by +5.98% | Jan 31, 26 |
| 17 | T. Rowe Price US Mid-Cap Growth Equity | 1.50M (0.84%) | 1.50M Increased by +100.00% | Jun 30, 25 |
| 18 | T. Rowe Price Mid-Cap Growth | 1.50M (0.84%) | -2.70K Decreased by -0.18% | Jul 31, 25 |
| 19 | Fidelity Growth Compy Commingled Pl O | 1.44M (0.81%) | 16.60K Increased by +1.15% | Aug 31, 24 |
| 20 | Janus Henderson Enterprise D | 1.42M (0.79%) | -668.40K Decreased by -47.13% | Jan 31, 26 |