| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 15.62M (15.92%) | -894.54K Decreased by -5.73% | Mar 31, 25 |
| 2 | T. Rowe Price Associates, Inc. | 10.81M (11.02%) | -529.37K Decreased by -4.90% | Jun 30, 25 |
| 3 | HHG PLC | 10.78M (10.99%) | -649.38K Decreased by -6.03% | Jun 30, 25 |
| 4 | BlackRock Inc | 9.92M (10.11%) | -14.89K Decreased by -0.15% | Mar 31, 25 |
| 5 | RTW INVESTMENTS, LLC | 9.62M (9.81%) | 871.92K Increased by +9.06% | Jun 30, 25 |
| 6 | Wellington Management Company LLP | 9.25M (9.43%) | -434.87K Decreased by -4.70% | Jun 30, 25 |
| 7 | Vanguard Group Inc | 9.25M (9.43%) | 5.10K Increased by +0.06% | Jun 30, 25 |
| 8 | venBio Select Advisor LLC | 7.05M (7.19%) | -575.00K Decreased by -8.16% | Jun 30, 25 |
| 9 | RA Capital Management, LLC | 6.30M (6.42%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | COWEN AND COMPANY, LLC | 5.13M (5.23%) | -500.00K Decreased by -9.75% | Jun 30, 24 |
| 11 | State Street Corp | 4.32M (4.41%) | -280.83K Decreased by -6.50% | Mar 31, 25 |
| 12 | State Street Corporation | 3.46M (3.53%) | 23.49K Increased by +0.68% | Mar 31, 24 |
| 13 | Geode Capital Management, LLC | 2.76M (2.81%) | -52.21K Decreased by -1.89% | Mar 31, 25 |
| 14 | Federated Hermes Inc | 2.36M (2.41%) | 0.00 Increased by 0.00% | Mar 31, 23 |
| 15 | Adage Capital Partners Gp LLC | 2.15M (2.19%) | -606.06K Decreased by -28.24% | Mar 31, 25 |
| 16 | Orbimed Advisors, LLC | 1.81M (1.85%) | 700.00K Increased by +38.61% | Mar 31, 25 |
| 17 | Polar Capital Holdings PLC | 1.79M (1.82%) | 516.98K Increased by +28.90% | Mar 31, 25 |
| 18 | Casdin Capital, LLC | 1.77M (1.81%) | -270.00K Decreased by -15.21% | Jun 30, 25 |
| 19 | Boxer Capital LLC | 1.73M (1.76%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 20 | Boxer Capital Management, LLC | 1.73M (1.76%) | 1.73M Increased by +100.00% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 5.38M (5.49%) | 142.09K Increased by +2.64% | Jun 30, 25 |
| 2 | Fidelity Growth Compy Commingled Pl O | 4.86M (4.95%) | -69.00K Decreased by -1.42% | Aug 31, 24 |
| 3 | T. Rowe Price New Horizons | 3.95M (4.03%) | -19.66K Decreased by -0.50% | Jun 30, 25 |
| 4 | US Small-Cap Growth II Equity Comp | 3.95M (4.03%) | -484.27K Decreased by -12.26% | Jun 30, 25 |
| 5 | Fidelity Growth Company Fund | 3.91M (3.99%) | 173.90K Increased by +4.44% | Jun 30, 25 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 3.65M (3.72%) | 15.98K Increased by +0.44% | Jun 30, 25 |
| 7 | Vanguard US Total Market Shares ETF | 3.53M (3.59%) | 3.12K Increased by +0.09% | Sep 30, 24 |
| 8 | Vanguard Health Care Inv | 2.83M (2.89%) | -196.40K Decreased by -6.93% | Jun 30, 25 |
| 9 | iShares Russell 2000 ETF | 2.69M (2.75%) | -51.13K Decreased by -1.90% | Jul 31, 25 |
| 10 | Fidelity Growth Compy Commingled Pl 3 | 2.64M (2.70%) | 639.36K Increased by +24.17% | Jun 30, 23 |
| 11 | T. Rowe Price Health Sciences | 2.30M (2.34%) | -51.31K Decreased by -2.23% | Jun 30, 25 |
| 12 | Vanguard Instl Ttl Stck Mkt Idx Tr | 1.95M (1.99%) | -61.60K Decreased by -3.15% | Mar 31, 23 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 1.86M (1.90%) | 6.54K Increased by +0.35% | Jun 30, 25 |
| 14 | Fidelity® Growth Company | 1.85M (1.88%) | 542.45K Increased by +29.38% | Jun 30, 23 |
| 15 | Janus Henderson Global Life Sciences D | 1.65M (1.68%) | -9.36K Decreased by -0.57% | May 31, 25 |
| 16 | Janus Henderson Global Life Sciences | 1.64M (1.67%) | -28.26K Decreased by -1.73% | Jun 30, 25 |
| 17 | T. Rowe Price Integrated US SmCapGrEq | 1.58M (1.61%) | 789.87K Increased by +50.00% | Dec 31, 24 |
| 18 | SPDR® S&P Biotech ETF | 1.55M (1.58%) | 46.23K Increased by +2.98% | Jul 31, 25 |
| 19 | Fidelity® Select Health Care | 1.40M (1.43%) | 900.00K Increased by +64.29% | Jun 30, 23 |
| 20 | Vanguard Small Cap Index | 1.40M (1.43%) | -33.08K Decreased by -2.37% | Jun 30, 25 |