| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 16.51M (17.81%) | -339.17K Decreased by -2.05% | Dec 31, 24 |
| 2 | T. Rowe Price Associates, Inc. | 11.04M (11.91%) | 408.86K Increased by +3.70% | Dec 31, 24 |
| 3 | BlackRock Inc | 9.93M (10.71%) | 205.45K Increased by +2.07% | Dec 31, 24 |
| 4 | Vanguard Group Inc | 9.43M (10.17%) | 205.03K Increased by +2.17% | Dec 31, 24 |
| 5 | Wellington Management Company LLP | 8.11M (8.74%) | 1.08M Increased by +13.26% | Dec 31, 24 |
| 6 | RTW INVESTMENTS, LLC | 7.93M (8.56%) | -200.00K Decreased by -2.52% | Dec 31, 24 |
| 7 | venBio Select Advisor LLC | 7.50M (8.09%) | 625.00K Increased by +8.33% | Dec 31, 24 |
| 8 | HHG PLC | 7.05M (7.61%) | 2.16M Increased by +30.58% | Dec 31, 24 |
| 9 | RA Capital Management, LLC | 6.30M (6.80%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 10 | COWEN AND COMPANY, LLC | 5.13M (5.53%) | -500.00K Decreased by -9.75% | Jun 30, 24 |
| 11 | State Street Corp | 4.60M (4.96%) | -103.92K Decreased by -2.26% | Dec 31, 24 |
| 12 | State Street Corporation | 3.46M (3.73%) | 23.49K Increased by +0.68% | Mar 31, 24 |
| 13 | Geode Capital Management, LLC | 2.81M (3.03%) | 222.15K Increased by +7.91% | Dec 31, 24 |
| 14 | Adage Capital Partners Gp LLC | 2.75M (2.97%) | -327.43K Decreased by -11.90% | Dec 31, 24 |
| 15 | Federated Hermes Inc | 2.36M (2.55%) | 0.00 Increased by 0.00% | Mar 31, 23 |
| 16 | Casdin Capital, LLC | 2.04M (2.21%) | -39.84K Decreased by -1.95% | Dec 31, 24 |
| 17 | Boxer Capital LLC | 1.73M (1.86%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 18 | Boxer Capital Management, LLC | 1.73M (1.86%) | 1.73M Increased by +100.00% | Dec 31, 24 |
| 19 | Artisan Partners Limited Partnership | 1.33M (1.43%) | -572.79K Decreased by -43.09% | Sep 30, 24 |
| 20 | Polar Capital Holdings PLC | 1.27M (1.37%) | -270.24K Decreased by -21.25% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 5.07M (5.47%) | 7.37K Increased by +0.15% | Feb 28, 25 |
| 2 | Fidelity Growth Compy Commingled Pl O | 4.86M (5.24%) | -69.00K Decreased by -1.42% | Aug 31, 24 |
| 3 | T. Rowe Price New Horizons | 4.49M (4.85%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 4 | US Small-Cap Growth II Equity Comp | 4.43M (4.78%) | -51.14K Decreased by -1.15% | Dec 31, 24 |
| 5 | Vanguard Total Stock Mkt Idx Inv | 3.57M (3.85%) | 29.09K Increased by +0.82% | Feb 28, 25 |
| 6 | Vanguard US Total Market Shares ETF | 3.53M (3.80%) | 3.12K Increased by +0.09% | Sep 30, 24 |
| 7 | Fidelity Growth Company Fund | 3.49M (3.77%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 8 | iShares Russell 2000 ETF | 2.99M (3.22%) | -25.85K Decreased by -0.87% | Mar 31, 25 |
| 9 | Fidelity Growth Compy Commingled Pl 3 | 2.64M (2.85%) | 639.36K Increased by +24.17% | Jun 30, 23 |
| 10 | T. Rowe Price Health Sciences | 2.49M (2.69%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 11 | Vanguard Health Care Inv | 2.35M (2.54%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 12 | Vanguard Instl Ttl Stck Mkt Idx Tr | 1.95M (2.11%) | -61.60K Decreased by -3.15% | Mar 31, 23 |
| 13 | Fidelity® Growth Company | 1.85M (1.99%) | 542.45K Increased by +29.38% | Jun 30, 23 |
| 14 | Vanguard Institutional Extnd Mkt Idx Tr | 1.82M (1.96%) | 2.57K Increased by +0.14% | Feb 28, 25 |
| 15 | SPDR® S&P Biotech ETF | 1.76M (1.90%) | -35.20K Decreased by -2.00% | Mar 31, 25 |
| 16 | Janus Henderson Global Life Sciences D | 1.58M (1.70%) | 331.17K Increased by +20.95% | Jan 31, 25 |
| 17 | T. Rowe Price Integrated US SmCapGrEq | 1.58M (1.70%) | 789.87K Increased by +50.00% | Dec 31, 24 |
| 18 | Vanguard Small Cap Index | 1.45M (1.56%) | 1.18K Increased by +0.08% | Feb 28, 25 |
| 19 | Fidelity® Select Health Care | 1.40M (1.51%) | 900.00K Increased by +64.29% | Jun 30, 23 |
| 20 | Janus Henderson Glb Life Scn I2 USD | 1.33M (1.44%) | 68.29K Increased by +5.12% | Feb 28, 25 |