| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 15.62M (17.02%) | -894.54K Decreased by -5.73% | Mar 31, 25 |
| 2 | HHG PLC | 11.43M (12.45%) | 4.37M Increased by +38.28% | Mar 31, 25 |
| 3 | T. Rowe Price Associates, Inc. | 11.34M (12.36%) | 295.27K Increased by +2.60% | Mar 31, 25 |
| 4 | BlackRock Inc | 9.92M (10.81%) | -14.89K Decreased by -0.15% | Mar 31, 25 |
| 5 | Wellington Management Company LLP | 9.68M (10.56%) | 1.58M Increased by +16.30% | Mar 31, 25 |
| 6 | Vanguard Group Inc | 9.24M (10.07%) | -188.71K Decreased by -2.04% | Mar 31, 25 |
| 7 | RTW INVESTMENTS, LLC | 8.75M (9.53%) | 814.06K Increased by +9.31% | Mar 31, 25 |
| 8 | venBio Select Advisor LLC | 7.63M (8.31%) | 125.00K Increased by +1.64% | Mar 31, 25 |
| 9 | RA Capital Management, LLC | 6.30M (6.87%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | COWEN AND COMPANY, LLC | 5.13M (5.59%) | -500.00K Decreased by -9.75% | Jun 30, 24 |
| 11 | State Street Corp | 4.32M (4.71%) | -280.83K Decreased by -6.50% | Mar 31, 25 |
| 12 | State Street Corporation | 3.46M (3.77%) | 23.49K Increased by +0.68% | Mar 31, 24 |
| 13 | Geode Capital Management, LLC | 2.76M (3.00%) | -52.21K Decreased by -1.89% | Mar 31, 25 |
| 14 | Federated Hermes Inc | 2.36M (2.58%) | 0.00 Increased by 0.00% | Mar 31, 23 |
| 15 | Adage Capital Partners Gp LLC | 2.15M (2.34%) | -606.06K Decreased by -28.24% | Mar 31, 25 |
| 16 | Casdin Capital, LLC | 2.04M (2.23%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 17 | Orbimed Advisors, LLC | 1.81M (1.98%) | 700.00K Increased by +38.61% | Mar 31, 25 |
| 18 | Polar Capital Holdings PLC | 1.79M (1.95%) | 516.98K Increased by +28.90% | Mar 31, 25 |
| 19 | Boxer Capital LLC | 1.73M (1.88%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 20 | Boxer Capital Management, LLC | 1.73M (1.88%) | 1.73M Increased by +100.00% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 5.24M (5.71%) | 29.32K Increased by +0.56% | May 31, 25 |
| 2 | Fidelity Growth Compy Commingled Pl O | 4.86M (5.29%) | -69.00K Decreased by -1.42% | Aug 31, 24 |
| 3 | T. Rowe Price New Horizons | 4.43M (4.83%) | -59.97K Decreased by -1.35% | Mar 31, 25 |
| 4 | US Small-Cap Growth II Equity Comp | 4.43M (4.83%) | 6.93K Increased by +0.16% | Mar 31, 25 |
| 5 | Fidelity Growth Company Fund | 3.74M (4.08%) | 26.38K Increased by +0.71% | May 31, 25 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 3.63M (3.96%) | 3.04K Increased by +0.08% | May 31, 25 |
| 7 | Vanguard US Total Market Shares ETF | 3.53M (3.84%) | 3.12K Increased by +0.09% | Sep 30, 24 |
| 8 | Vanguard Health Care Inv | 3.03M (3.30%) | 676.97K Increased by +22.34% | Mar 31, 25 |
| 9 | iShares Russell 2000 ETF | 2.86M (3.11%) | 19.84K Increased by +0.69% | Jun 30, 25 |
| 10 | Fidelity Growth Compy Commingled Pl 3 | 2.64M (2.88%) | 639.36K Increased by +24.17% | Jun 30, 23 |
| 11 | T. Rowe Price Health Sciences | 2.42M (2.63%) | -76.44K Decreased by -3.16% | Mar 31, 25 |
| 12 | Vanguard Instl Ttl Stck Mkt Idx Tr | 1.95M (2.13%) | -61.60K Decreased by -3.15% | Mar 31, 23 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 1.86M (2.02%) | 13.12K Increased by +0.71% | May 31, 25 |
| 14 | Fidelity® Growth Company | 1.85M (2.01%) | 542.45K Increased by +29.38% | Jun 30, 23 |
| 15 | Janus Henderson Global Life Sciences | 1.67M (1.82%) | 416.87K Increased by +25.02% | Mar 31, 25 |
| 16 | Janus Henderson Global Life Sciences D | 1.66M (1.81%) | -6.70K Decreased by -0.40% | Apr 30, 25 |
| 17 | T. Rowe Price Integrated US SmCapGrEq | 1.58M (1.72%) | 789.87K Increased by +50.00% | Dec 31, 24 |
| 18 | SPDR® S&P Biotech ETF | 1.55M (1.69%) | -25.35K Decreased by -1.64% | Jun 30, 25 |
| 19 | Vanguard Small Cap Index | 1.43M (1.56%) | 9.88K Increased by +0.69% | May 31, 25 |
| 20 | Fidelity® Select Health Care | 1.40M (1.53%) | 900.00K Increased by +64.29% | Jun 30, 23 |