| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 10.26M (10.85%) | 131.09K Increased by +1.28% | Dec 31, 25 |
| 2 | BlackRock Inc | 6.63M (7.01%) | 206.29K Increased by +3.11% | Dec 31, 25 |
| 3 | State Street Corp | 4.30M (4.55%) | 610.56K Increased by +14.19% | Dec 31, 25 |
| 4 | JPMorgan Chase & Co | 3.97M (4.20%) | -4.05M Decreased by -101.88% | Dec 31, 25 |
| 5 | RTW INVESTMENTS, LLC | 3.65M (3.86%) | 648.66K Increased by +17.78% | Mar 31, 26 |
| 6 | Sands Capital Management, LLC | 3.21M (3.40%) | -271.19K Decreased by -8.44% | Mar 31, 26 |
| 7 | Sofinnova Ventures | 3.15M (3.33%) | 3.06M Increased by +97.35% | Mar 31, 26 |
| 8 | State Street Corporation | 2.85M (3.01%) | -401.25K Decreased by -14.07% | Mar 31, 24 |
| 9 | Baker Bros Advisors LP | 2.77M (2.93%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | FMR Inc | 2.67M (2.82%) | -4.62M Decreased by -173.17% | Dec 31, 25 |
| 11 | Wellington Management Company LLP | 2.46M (2.60%) | 516.78K Increased by +20.99% | Dec 31, 25 |
| 12 | Citadel Advisors Llc | 2.33M (2.46%) | 2.00M Increased by +85.77% | Dec 31, 25 |
| 13 | Assenagon Asset Management SA | 2.26M (2.39%) | 2.06M Increased by +91.15% | Mar 31, 26 |
| 14 | Frontier Capital Management CO Inc | 2.19M (2.32%) | 226.10K Increased by +10.32% | Mar 31, 26 |
| 15 | ClearBridge Advisors, LLC | 2.14M (2.26%) | -119.13K Decreased by -5.57% | Jun 30, 25 |
| 16 | Federated Hermes Inc | 2.05M (2.17%) | -5.70K Decreased by -0.28% | Jun 30, 25 |
| 17 | Suvretta Capital Management, LLC | 2.02M (2.13%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 18 | Millennium Management LLC | 1.85M (1.96%) | 1.14M Increased by +61.75% | Jun 30, 24 |
| 19 | Geode Capital Management, LLC | 1.84M (1.94%) | 257.70K Increased by +14.02% | Dec 31, 25 |
| 20 | Morgan Stanley - Brokerage Accounts | 1.83M (1.93%) | 916.11K Increased by +50.16% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | State Street® SPDR® S&P® Biotech ETF | 3.47M (3.67%) | -24.68K Decreased by -0.71% | Apr 30, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.94M (3.11%) | 25.59K Increased by +0.87% | Mar 31, 26 |
| 3 | Vanguard US Total Market Shares ETF | 2.81M (2.97%) | 92.60K Increased by +3.30% | Sep 30, 24 |
| 4 | Vanguard Small Cap Index | 2.12M (2.24%) | 43.09K Increased by +2.03% | Mar 31, 26 |
| 5 | Sands Capital Select Growth TE Inst EQ | 1.94M (2.05%) | -147.38K Decreased by -7.60% | Mar 31, 26 |
| 6 | Vanguard Explorer Inv | 1.72M (1.82%) | 189.69K Increased by +11.02% | Mar 31, 26 |
| 7 | JPM US Mid Cap Growth-Composite | 1.59M (1.68%) | -37.19K Decreased by -2.34% | Dec 31, 25 |
| 8 | JPMorgan Mid Cap Growth I | 1.59M (1.68%) | -10.19K Decreased by -0.64% | Dec 31, 25 |
| 9 | Hartford MidCap Y | 1.28M (1.36%) | -24.56K Decreased by -1.91% | Oct 31, 24 |
| 10 | Vanguard Health Care Inv | 1.25M (1.32%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 11 | Vanguard Small Cap Growth Index Inv | 1.19M (1.26%) | 32.03K Increased by +2.69% | Mar 31, 26 |
| 12 | DWS Vermögensbildungsfonds I LD | 1.18M (1.25%) | 4.00 Increased by +0.00% | Jul 31, 25 |
| 13 | First Trust NYSE Arca Biotech ETF | 1.14M (1.20%) | -92.00 Decreased by -0.01% | Dec 28, 23 |
| 14 | Federated Hermes Kaufmann Small Cap A | 1.09M (1.15%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 15 | Federated Hermes Kaufmann Small Cap Grow | 1.09M (1.15%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 16 | Vanguard Institutional Extnd Mkt Idx Tr | 1.08M (1.14%) | 24.15K Increased by +2.24% | Mar 31, 26 |
| 17 | Strategic Advisers Fidelity US TtlStk | 1.06M (1.12%) | -1.79M Decreased by -169.55% | Dec 31, 25 |
| 18 | Fidelity® Select Biotechnology | 1.04M (1.10%) | -188.62K Decreased by -18.15% | Nov 30, 23 |
| 19 | SPDR® S&P Biotech ETF | 990.31K (1.05%) | 2.21K Increased by +0.22% | Aug 31, 25 |
| 20 | Federated Hermes Kaufmann Growth | 932.50K (0.99%) | 0.00 Increased by 0.00% | Jun 30, 25 |