| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 10.69M (83.05%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | RTW INVESTMENTS, LLC | 3.19M (24.81%) | 3.19M Increased by +100.00% | Dec 31, 24 |
| 3 | Point72 Asset Management, L.P. | 2.68M (20.79%) | 2.68M Increased by +100.00% | Mar 31, 25 |
| 4 | Suvretta Capital Management, LLC | 1.66M (12.90%) | 486.61K Increased by +29.30% | Mar 31, 25 |
| 5 | Viking Global Investors LP | 1.48M (11.52%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 6 | Adage Capital Partners Gp LLC | 1.35M (10.49%) | 550.00K Increased by +40.74% | Mar 31, 25 |
| 7 | BlackRock Inc | 1.29M (10.06%) | 8.13K Increased by +0.63% | Mar 31, 25 |
| 8 | Millennium Management LLC | 1.03M (8.03%) | 876.38K Increased by +84.84% | Mar 31, 25 |
| 9 | Vanguard Group Inc | 899.73K (6.99%) | -12.94K Decreased by -1.44% | Mar 31, 25 |
| 10 | Perceptive Advisors LLC | 829.54K (6.45%) | -580.90K Decreased by -70.03% | Dec 31, 24 |
| 11 | LAURION CAPITAL MANAGEMENT LP | 810.76K (6.30%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | Woodline Partners LP | 780.90K (6.07%) | 780.90K Increased by +100.00% | Mar 31, 25 |
| 13 | Orbimed Advisors, LLC | 653.02K (5.07%) | -144.34K Decreased by -22.10% | Dec 31, 24 |
| 14 | Samsara BioCapital, LLC | 651.05K (5.06%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 15 | Sofinnova Ventures | 561.13K (4.36%) | 57.50K Increased by +10.25% | Jun 30, 24 |
| 16 | Polar Capital Holdings PLC | 531.10K (4.13%) | 531.10K Increased by +100.00% | Jun 30, 24 |
| 17 | HHG PLC | 522.26K (4.06%) | -1.81M Decreased by -347.39% | Dec 31, 24 |
| 18 | Opaleye Management Inc | 420.00K (3.26%) | 310.00K Increased by +73.81% | Mar 31, 25 |
| 19 | Geode Capital Management, LLC | 383.89K (2.98%) | 11.04K Increased by +2.88% | Mar 31, 25 |
| 20 | Octagon Capital Advisors LP | 376.12K (2.92%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity® Select Biotechnology | 737.00K (5.73%) | 444.16K Increased by +60.27% | Nov 30, 23 |
| 2 | Vanguard US Total Market Shares ETF | 492.80K (3.83%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 482.71K (3.75%) | 0.00 Increased by 0.00% | May 31, 25 |
| 4 | Biotech Growth Ord | 409.12K (3.18%) | 0.00 Increased by 0.00% | Jan 31, 25 |
| 5 | Fidelity Series Small Cap Opps | 383.52K (2.98%) | -229.55K Decreased by -59.85% | Oct 31, 23 |
| 6 | Fidelity® Series Small Cap Opps | 383.52K (2.98%) | -229.55K Decreased by -59.85% | Oct 31, 23 |
| 7 | Vanguard Institutional Extnd Mkt Idx Tr | 289.48K (2.25%) | 0.00 Increased by 0.00% | May 31, 25 |
| 8 | Fidelity Small Cap Growth | 225.69K (1.75%) | -117.21K Decreased by -51.93% | Oct 31, 23 |
| 9 | Fidelity® Small Cap Growth | 225.69K (1.75%) | -117.21K Decreased by -51.93% | Oct 31, 23 |
| 10 | Fidelity Stock Selector Small Cap | 213.36K (1.66%) | -118.10K Decreased by -55.35% | Oct 31, 23 |
| 11 | Fidelity® Stock Selector Small Cap | 213.36K (1.66%) | -118.10K Decreased by -55.35% | Oct 31, 23 |
| 12 | iShares Biotechnology ETF | 179.05K (1.39%) | -645.00 Decreased by -0.36% | Jun 30, 25 |
| 13 | Fidelity Small Cap Index | 155.98K (1.21%) | -239.00 Decreased by -0.15% | Apr 30, 25 |
| 14 | Fidelity® Small Cap Index | 94.09K (0.73%) | 3.49K Increased by +3.70% | Oct 31, 23 |
| 15 | Fidelity Extended Market Index | 93.45K (0.73%) | -418.00 Decreased by -0.45% | May 31, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx NL Cl C | 90.99K (0.71%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 90.99K (0.71%) | 0.00 Increased by 0.00% | May 31, 25 |
| 18 | iShares Russell 2000 ETF | 88.89K (0.69%) | -3.66K Decreased by -4.12% | Jun 30, 25 |
| 19 | Vanguard Russell 2000 ETF | 77.58K (0.60%) | 689.00 Increased by +0.89% | May 31, 25 |
| 20 | Fidelity Advisor Small Cap I | 74.70K (0.58%) | -47.90K Decreased by -64.12% | Oct 31, 23 |