| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Deerfield Management Co | 17.25M (35.43%) | -742.57K Decreased by -4.31% | Dec 31, 25 |
| 2 | FMR Inc | 10.85M (22.30%) | 839.65K Increased by +7.74% | Dec 31, 25 |
| 3 | Paradigm Biocapital Advisors LP | 5.27M (10.83%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 4 | Vanguard Group Inc | 5.24M (10.77%) | 639.26K Increased by +12.19% | Dec 31, 25 |
| 5 | BlackRock Inc | 4.09M (8.39%) | 39.54K Increased by +0.97% | Sep 30, 25 |
| 6 | JPMorgan Chase & Co | 3.35M (6.88%) | 2.15M Increased by +64.24% | Sep 30, 25 |
| 7 | Wellington Management Company LLP | 2.46M (5.06%) | 160.96K Increased by +6.54% | Dec 31, 25 |
| 8 | HHG PLC | 2.19M (4.50%) | 406.09K Increased by +18.55% | Sep 30, 25 |
| 9 | RA Capital Management, LLC | 1.88M (3.86%) | 633.60K Increased by +33.70% | Dec 31, 25 |
| 10 | T. Rowe Price Associates, Inc. | 1.81M (3.72%) | 15.05K Increased by +0.83% | Sep 30, 25 |
| 11 | State Street Corporation | 1.70M (3.49%) | 440.77K Increased by +25.91% | Dec 31, 23 |
| 12 | T. Rowe Price Investment Management,Inc. | 1.69M (3.47%) | 667.50K Increased by +39.53% | Dec 31, 25 |
| 13 | State Street Corp | 1.57M (3.24%) | 84.47K Increased by +5.36% | Sep 30, 25 |
| 14 | Perceptive Advisors LLC | 1.56M (3.21%) | 187.16K Increased by +11.98% | Sep 30, 25 |
| 15 | Polar Capital Holdings PLC | 1.54M (3.16%) | 514.63K Increased by +33.49% | Dec 31, 25 |
| 16 | Bain Capital Life Sciences Investors, LLC | 1.45M (2.97%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 17 | COMMODORE CAPITAL LP | 1.40M (2.88%) | 25.00K Increased by +1.79% | Sep 30, 25 |
| 18 | Geode Capital Management, LLC | 1.24M (2.54%) | 144.24K Increased by +11.65% | Dec 31, 25 |
| 19 | Boxer Capital LLC | 1.12M (2.30%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 20 | Boxer Capital Management, LLC | 1.12M (2.30%) | 1.12M Increased by +100.00% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl O | 2.48M (5.08%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 2 | Fidelity Growth Compy Commingled Pl S | 1.85M (3.80%) | -411.60K Decreased by -22.25% | Feb 28, 26 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 1.74M (3.57%) | 4.00K Increased by +0.23% | Feb 28, 26 |
| 4 | Fidelity® Growth Company | 1.60M (3.29%) | 36.30K Increased by +2.27% | Nov 30, 23 |
| 5 | Fidelity Growth Company Fund | 1.47M (3.01%) | -292.10K Decreased by -19.91% | Feb 28, 26 |
| 6 | Vanguard Small Cap Index | 1.22M (2.51%) | 3.44K Increased by +0.28% | Feb 28, 26 |
| 7 | iShares Russell 2000 ETF | 1.21M (2.49%) | -9.92K Decreased by -0.82% | Mar 31, 26 |
| 8 | Vanguard Health Care Inv | 1.05M (2.17%) | -183.02K Decreased by -17.36% | Dec 31, 25 |
| 9 | Polar Capital Biotech S Inc | 900.00K (1.85%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 10 | State Street® SPDR® S&P® Biotech ETF | 846.77K (1.74%) | 12.74K Increased by +1.50% | Mar 31, 26 |
| 11 | Strategic Advisers Fidelity US TtlStk | 788.46K (1.62%) | 281.17K Increased by +35.66% | Feb 28, 26 |
| 12 | Vanguard Small Cap Value Index Inv | 785.28K (1.61%) | 2.25K Increased by +0.29% | Feb 28, 26 |
| 13 | Fidelity Select Health Care | 760.00K (1.56%) | 955.00 Increased by +0.13% | Feb 28, 26 |
| 14 | JPMorgan Growth Advantage A | 713.75K (1.47%) | -3.64K Decreased by -0.51% | Feb 28, 26 |
| 15 | Fidelity® Growth Company K6 | 617.41K (1.27%) | 540.00 Increased by +0.09% | Nov 30, 23 |
| 16 | JPM US Mid Cap Growth-Composite | 613.05K (1.26%) | -29.80K Decreased by -4.86% | Dec 31, 25 |
| 17 | JPMorgan Mid Cap Growth I | 610.84K (1.25%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 18 | Polar Capital Healthcare Opports Inc | 600.04K (1.23%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 19 | SPDR® S&P Biotech ETF | 590.59K (1.21%) | 1.31K Increased by +0.22% | Aug 31, 25 |
| 20 | Vanguard Institutional Extnd Mkt Idx Tr | 567.41K (1.17%) | 5.25K Increased by +0.93% | Feb 28, 26 |