| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Deerfield Management Co | 17.25M (35.20%) | -742.57K Decreased by -4.31% | Dec 31, 25 |
| 2 | FMR Inc | 10.85M (22.15%) | 839.65K Increased by +7.74% | Dec 31, 25 |
| 3 | Paradigm Biocapital Advisors LP | 5.32M (10.87%) | 55.00K Increased by +1.03% | Mar 31, 26 |
| 4 | Vanguard Group Inc | 5.24M (10.70%) | 639.26K Increased by +12.19% | Dec 31, 25 |
| 5 | BlackRock Inc | 4.81M (9.81%) | 719.47K Increased by +14.97% | Dec 31, 25 |
| 6 | JPMorgan Chase & Co | 3.09M (6.30%) | 883.10K Increased by +28.59% | Mar 31, 26 |
| 7 | Wellington Management Company LLP | 2.46M (5.02%) | 160.96K Increased by +6.54% | Dec 31, 25 |
| 8 | T. Rowe Price Associates, Inc. | 2.15M (4.38%) | 336.52K Increased by +15.67% | Dec 31, 25 |
| 9 | RA Capital Management, LLC | 1.88M (3.84%) | 633.60K Increased by +33.70% | Dec 31, 25 |
| 10 | State Street Corp | 1.86M (3.81%) | 289.93K Increased by +15.55% | Dec 31, 25 |
| 11 | State Street Corporation | 1.70M (3.47%) | 440.77K Increased by +25.91% | Dec 31, 23 |
| 12 | T. Rowe Price Investment Management,Inc. | 1.69M (3.45%) | 667.50K Increased by +39.53% | Dec 31, 25 |
| 13 | Perceptive Advisors LLC | 1.56M (3.19%) | 187.16K Increased by +11.98% | Sep 30, 25 |
| 14 | Polar Capital Holdings PLC | 1.54M (3.14%) | 514.63K Increased by +33.49% | Dec 31, 25 |
| 15 | HHG PLC | 1.50M (3.06%) | -689.10K Decreased by -45.95% | Dec 31, 25 |
| 16 | Bain Capital Life Sciences Investors, LLC | 1.45M (2.95%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 17 | Geode Capital Management, LLC | 1.24M (2.53%) | 144.24K Increased by +11.65% | Dec 31, 25 |
| 18 | Boxer Capital LLC | 1.12M (2.29%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 19 | Boxer Capital Management, LLC | 1.12M (2.29%) | 1.12M Increased by +100.00% | Dec 31, 24 |
| 20 | Vestal Point Capital LP | 1.07M (2.19%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl O | 2.48M (5.05%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.75M (3.57%) | 11.90K Increased by +0.68% | Mar 31, 26 |
| 3 | Fidelity® Growth Company | 1.60M (3.27%) | 36.30K Increased by +2.27% | Nov 30, 23 |
| 4 | Fidelity Growth Compy Commingled Pl S | 1.37M (2.81%) | -474.66K Decreased by -34.52% | Mar 31, 26 |
| 5 | Vanguard Small Cap Index | 1.27M (2.59%) | 44.30K Increased by +3.50% | Mar 31, 26 |
| 6 | Fidelity Growth Company Fund | 1.21M (2.48%) | -253.50K Decreased by -20.89% | Mar 31, 26 |
| 7 | iShares Russell 2000 ETF | 1.18M (2.40%) | 9.92K Increased by +0.84% | Apr 30, 26 |
| 8 | Vanguard Health Care Inv | 1.05M (2.15%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 9 | Polar Capital Biotech S Inc | 964.07K (1.97%) | 64.07K Increased by +6.65% | Mar 31, 26 |
| 10 | State Street® SPDR® S&P® Biotech ETF | 946.64K (1.93%) | -6.73K Decreased by -0.71% | Apr 30, 26 |
| 11 | Strategic Advisers Fidelity US TtlStk | 844.55K (1.72%) | 56.09K Increased by +6.64% | Mar 31, 26 |
| 12 | Vanguard Small Cap Value Index Inv | 806.40K (1.65%) | 21.12K Increased by +2.62% | Mar 31, 26 |
| 13 | Fidelity Select Health Care | 728.00K (1.49%) | -32.00K Decreased by -4.40% | Mar 31, 26 |
| 14 | JPMorgan Growth Advantage A | 709.35K (1.45%) | -4.40K Decreased by -0.62% | Mar 31, 26 |
| 15 | Fidelity® Growth Company K6 | 617.41K (1.26%) | 540.00 Increased by +0.09% | Nov 30, 23 |
| 16 | JPM US Mid Cap Growth-Composite | 607.45K (1.24%) | -5.60K Decreased by -0.92% | Mar 31, 26 |
| 17 | JPMorgan Mid Cap Growth I | 607.45K (1.24%) | -3.39K Decreased by -0.56% | Mar 31, 26 |
| 18 | Polar Capital Healthcare Opports Inc | 600.04K (1.22%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 19 | SPDR® S&P Biotech ETF | 590.59K (1.21%) | 1.31K Increased by +0.22% | Aug 31, 25 |
| 20 | Vanguard Institutional Extnd Mkt Idx Tr | 587.69K (1.20%) | 20.28K Increased by +3.45% | Mar 31, 26 |