| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 6.77M (17.40%) | 2.30M Increased by +33.91% | Sep 30, 23 |
| 2 | venBio Select Advisor LLC | 6.67M (17.14%) | 1.11M Increased by +16.67% | Sep 30, 23 |
| 3 | EcoR1 Capital, LLC | 5.75M (14.78%) | 5.75M Increased by +100.00% | Sep 30, 23 |
| 4 | Vanguard Group Inc | 5.70M (14.65%) | 721.36K Increased by +12.66% | Sep 30, 23 |
| 5 | BlackRock Inc | 3.54M (9.11%) | 226.29K Increased by +6.38% | Sep 30, 23 |
| 6 | Wellington Management Company LLP | 3.32M (8.53%) | -68.44K Decreased by -2.06% | Sep 30, 23 |
| 7 | Boxer Capital LLC | 3.20M (8.23%) | 1.20M Increased by +37.53% | Sep 30, 23 |
| 8 | Aviva Holdings Ltd | 3.14M (8.06%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 9 | State Street Corporation | 2.75M (7.06%) | 164.23K Increased by +5.98% | Sep 30, 23 |
| 10 | Morgan Stanley - Brokerage Accounts | 2.46M (6.33%) | -382.34K Decreased by -15.53% | Sep 30, 23 |
| 11 | T. Rowe Price Associates, Inc. | 2.43M (6.25%) | 655.45K Increased by +26.94% | Sep 30, 23 |
| 12 | Artal Group S A | 2.02M (5.20%) | -30.95K Decreased by -1.53% | Sep 30, 23 |
| 13 | Orbimed Advisors, LLC | 1.96M (5.04%) | 1.05M Increased by +53.36% | Sep 30, 23 |
| 14 | Assenagon Asset Management SA | 1.83M (4.69%) | 1.02M Increased by +55.70% | Sep 30, 23 |
| 15 | Paradigm Biocapital Advisors LP | 1.67M (4.29%) | 224.35K Increased by +13.45% | Sep 30, 23 |
| 16 | FMR Inc | 1.53M (3.93%) | 1.40M Increased by +91.90% | Sep 30, 23 |
| 17 | Camber Capital Management LLC | 1.50M (3.86%) | -300.00K Decreased by -20.00% | Sep 30, 23 |
| 18 | Baker Bros Advisors LP | 1.41M (3.62%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 19 | Armistice Capital, LLC | 1.36M (3.51%) | -2.61M Decreased by -191.62% | Sep 30, 23 |
| 20 | Adage Capital Partners Gp LLC | 1.18M (3.02%) | 1.18M Increased by +100.00% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 2.56M (6.58%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.82M (4.67%) | -97.91K Decreased by -5.39% | Dec 31, 23 |
| 3 | Vanguard Small Cap Index | 1.45M (3.73%) | -135.83K Decreased by -9.37% | Dec 31, 23 |
| 4 | SPDR® S&P Biotech ETF | 1.41M (3.62%) | -8.17K Decreased by -0.58% | Dec 31, 23 |
| 5 | T. Rowe Price Health Sciences | 1.24M (3.19%) | 433.44K Increased by +34.97% | Sep 30, 23 |
| 6 | Worldwide Healthcare Ord | 1.22M (3.13%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 7 | Vanguard Institutional Extnd Mkt Idx Tr | 867.45K (2.23%) | -39.05K Decreased by -4.50% | Dec 31, 23 |
| 8 | Vanguard Small Cap Growth Index Inv | 809.87K (2.08%) | -77.08K Decreased by -9.52% | Dec 31, 23 |
| 9 | Eventide Healthcare & Life Sciences I | 600.00K (1.54%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 10 | Candriam Global Equities Oncology | 499.72K (1.28%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 11 | iShares Biotechnology ETF | 477.47K (1.23%) | -435.00 Decreased by -0.09% | Dec 29, 23 |
| 12 | Fiera SMID Growth | 474.18K (1.22%) | 186.63K Increased by +39.36% | Sep 30, 23 |
| 13 | Belfius Equities Cure C Cap | 439.72K (1.13%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 14 | US Small-Cap Growth II Equity Comp | 414.56K (1.07%) | 414.56K Increased by +100.00% | Jun 30, 23 |
| 15 | T. Rowe Price New Horizons | 414.41K (1.07%) | -142.00 Decreased by -0.03% | Sep 30, 23 |
| 16 | FIAM Small Cap Core Composite | 352.10K (0.91%) | 352.10K Increased by +100.00% | Sep 30, 23 |
| 17 | Fidelity Extended Market Index | 336.74K (0.87%) | 3.71K Increased by +1.10% | Nov 30, 23 |
| 18 | Fidelity® Extended Market Index | 333.03K (0.86%) | 7.59K Increased by +2.28% | Oct 31, 23 |
| 19 | State St Russell Sm/Mid Cp® Indx NL Cl C | 321.24K (0.83%) | 58.10K Increased by +18.09% | Dec 31, 23 |
| 20 | Schwab US Small-Cap ETF™ | 292.76K (0.75%) | 129.00 Increased by +0.04% | Dec 30, 23 |