| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 8.93M (16.22%) | 3.05M Increased by +34.15% | Dec 31, 25 |
| 2 | Baker Bros Advisors LP | 8.66M (15.73%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 3 | venBio Select Advisor LLC | 7.47M (13.58%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 4 | Vanguard Group Inc | 6.27M (11.39%) | 845.92K Increased by +13.50% | Dec 31, 25 |
| 5 | T. Rowe Price Associates, Inc. | 6.16M (11.19%) | 1.06M Increased by +17.24% | Dec 31, 25 |
| 6 | Bvf Inc | 5.50M (10.00%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 7 | BlackRock Inc | 5.00M (9.09%) | 638.65K Increased by +12.76% | Dec 31, 25 |
| 8 | Atlas Venture Life Science Advisors, LLC | 4.58M (8.32%) | -81.87K Decreased by -1.79% | Mar 31, 26 |
| 9 | Wellington Management Company LLP | 4.41M (8.02%) | -782.76K Decreased by -17.74% | Dec 31, 25 |
| 10 | Siren, L.L.C. | 3.29M (5.97%) | -141.32K Decreased by -4.30% | Dec 31, 25 |
| 11 | Artal Group S A | 3.01M (5.46%) | -21.52K Decreased by -0.72% | Jun 30, 24 |
| 12 | State Street Corporation | 2.67M (4.85%) | 778.24K Increased by +29.12% | Mar 31, 24 |
| 13 | State Street Corp | 2.21M (4.01%) | 190.38K Increased by +8.62% | Dec 31, 25 |
| 14 | Capital Research Global Investors | 1.67M (3.04%) | 112.48K Increased by +6.72% | Mar 31, 26 |
| 15 | Geode Capital Management, LLC | 1.42M (2.57%) | 140.62K Increased by +9.92% | Dec 31, 25 |
| 16 | Driehaus Capital Management LLC | 1.07M (1.94%) | 130.14K Increased by +12.17% | Dec 31, 25 |
| 17 | UBS Group AG | 1.02M (1.86%) | 286.82K Increased by +28.01% | Mar 31, 26 |
| 18 | AllianceBernstein L.P. | 952.07K (1.73%) | 903.30K Increased by +94.88% | Dec 31, 25 |
| 19 | Aquilo Capital Management, LLC | 881.34K (1.60%) | 99.12K Increased by +11.25% | Dec 31, 23 |
| 20 | UBS Asset Mgmt Americas Inc | 875.87K (1.59%) | -36.63K Decreased by -4.18% | Mar 31, 26 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 2.84M (5.15%) | 8.16K Increased by +0.29% | Mar 31, 26 |
| 2 | Fidelity Growth Compy Commingled Pl O | 2.24M (4.06%) | 52.60K Increased by +2.35% | Aug 31, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 2.08M (3.78%) | -44.27K Decreased by -2.13% | Mar 31, 26 |
| 4 | Fidelity Growth Company Fund | 2.08M (3.78%) | 15.00K Increased by +0.72% | Mar 31, 26 |
| 5 | T. Rowe Price New Horizons | 1.95M (3.54%) | -33.35K Decreased by -1.71% | Mar 31, 26 |
| 6 | US Small-Cap Growth II Equity Comp | 1.95M (3.54%) | -18.26K Decreased by -0.94% | Mar 31, 26 |
| 7 | Vanguard Health Care Inv | 1.80M (3.26%) | -375.38K Decreased by -20.90% | Mar 31, 26 |
| 8 | Vanguard US Total Market Shares ETF | 1.54M (2.80%) | 1.91K Increased by +0.12% | Sep 30, 24 |
| 9 | Vanguard Small Cap Index | 1.51M (2.74%) | -16.13K Decreased by -1.07% | Mar 31, 26 |
| 10 | American Funds SMALLCAP World A | 1.49M (2.70%) | 97.27K Increased by +6.55% | Mar 31, 26 |
| 11 | iShares Russell 2000 ETF | 1.35M (2.45%) | 11.37K Increased by +0.84% | Apr 30, 26 |
| 12 | State Street® SPDR® S&P® Biotech ETF | 1.16M (2.11%) | -8.24K Decreased by -0.71% | Apr 30, 26 |
| 13 | T. Rowe Price Health Sciences | 1.07M (1.94%) | -21.20K Decreased by -1.99% | Mar 31, 26 |
| 14 | T. Rowe Price New Horizons Tr-A | 901.33K (1.64%) | 55.81K Increased by +6.19% | Mar 31, 26 |
| 15 | T. Rowe Price New Horizons Tr-Z | 872.24K (1.58%) | 65.62K Increased by +7.52% | Mar 31, 25 |
| 16 | Vanguard Small Cap Growth Index Inv | 842.18K (1.53%) | -4.25K Decreased by -0.51% | Mar 31, 26 |
| 17 | T. Rowe Price Small-Cap Stock | 790.95K (1.44%) | 249.74K Increased by +31.57% | Mar 31, 26 |
| 18 | T. Rowe Price US Small-Cap Core Equity | 790.95K (1.44%) | 550.29K Increased by +69.57% | Mar 31, 26 |
| 19 | Vanguard Institutional Extnd Mkt Idx Tr | 686.42K (1.25%) | 23.70K Increased by +3.45% | Mar 31, 26 |
| 20 | Vanguard Explorer Inv | 644.11K (1.17%) | -516.00 Decreased by -0.08% | Mar 31, 26 |