| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 4.35M (18.78%) | 8.18K Increased by +0.19% | Dec 31, 25 |
| 2 | BlackRock Inc | 3.83M (16.55%) | -11.03K Decreased by -0.29% | Sep 30, 25 |
| 3 | venBio Select Advisor LLC | 2.89M (12.47%) | 111.11K Increased by +3.85% | Dec 31, 25 |
| 4 | Vanguard Group Inc | 2.78M (12.00%) | -13.36K Decreased by -0.48% | Dec 31, 25 |
| 5 | State Street Corp | 1.40M (6.03%) | 40.62K Increased by +2.91% | Sep 30, 25 |
| 6 | State Street Corporation | 944.55K (4.08%) | -292.95K Decreased by -31.01% | Mar 31, 24 |
| 7 | Soleus Capital Management, L.P. | 941.06K (4.06%) | -77.77K Decreased by -8.26% | Dec 31, 25 |
| 8 | Capital World Investors | 809.50K (3.49%) | 260.00 Increased by +0.03% | Dec 31, 25 |
| 9 | BRAIDWELL LP | 727.81K (3.14%) | 327.07K Increased by +44.94% | Jun 30, 25 |
| 10 | Point72 Asset Management, L.P. | 698.16K (3.01%) | 138.90K Increased by +19.89% | Sep 30, 23 |
| 11 | Redmile Group, LLC | 677.71K (2.93%) | 16.32K Increased by +2.41% | Dec 31, 25 |
| 12 | Hood River Capital Management LLC | 613.30K (2.65%) | 6.36K Increased by +1.04% | Dec 31, 25 |
| 13 | Geode Capital Management, LLC | 611.88K (2.64%) | 634.00 Increased by +0.10% | Dec 31, 25 |
| 14 | Goldman Sachs Group Inc | 530.36K (2.29%) | 296.72K Increased by +55.95% | Jun 30, 25 |
| 15 | Dimensional Fund Advisors, Inc. | 492.97K (2.13%) | -41.00K Decreased by -8.32% | Dec 31, 25 |
| 16 | Frazier Life Sciences Management, L.P. | 488.46K (2.11%) | -200.00K Decreased by -40.95% | Dec 31, 25 |
| 17 | T. Rowe Price Associates, Inc. | 467.06K (2.02%) | 205.68K Increased by +44.04% | Sep 30, 25 |
| 18 | Bellevue Group AG | 410.32K (1.77%) | 409.01K Increased by +99.68% | Dec 31, 25 |
| 19 | Citadel Advisors Llc | 386.50K (1.67%) | -250.48K Decreased by -64.81% | Dec 31, 25 |
| 20 | William Blair Investment Management, LLC | 376.34K (1.62%) | 227.04K Increased by +60.33% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity® Select Biotechnology | 1.99M (8.57%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 2 | Fidelity Select Biotechnology | 1.81M (7.80%) | -5.90K Decreased by -0.33% | Feb 28, 26 |
| 3 | iShares Core S&P Small-Cap ETF | 1.55M (6.69%) | 545.00 Increased by +0.04% | Mar 31, 26 |
| 4 | Fidelity Growth Compy Commingled Pl S | 1.04M (4.50%) | -8.89K Decreased by -0.85% | Feb 28, 26 |
| 5 | Fidelity Growth Compy Commingled Pl O | 915.43K (3.95%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 826.46K (3.57%) | 1.53K Increased by +0.19% | Feb 28, 26 |
| 7 | Vanguard US Total Market Shares ETF | 824.72K (3.56%) | 704.00 Increased by +0.09% | Sep 30, 24 |
| 8 | Fidelity Growth Company Fund | 775.52K (3.35%) | 23.84K Increased by +3.07% | Feb 28, 26 |
| 9 | American Funds SMALLCAP World A | 752.24K (3.25%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | iShares Russell 2000 ETF | 600.77K (2.59%) | -4.89K Decreased by -0.81% | Mar 31, 26 |
| 11 | Vanguard Small Cap Index | 592.73K (2.56%) | 1.57K Increased by +0.26% | Feb 28, 26 |
| 12 | SPDR® S&P Biotech ETF | 423.10K (1.83%) | 945.00 Increased by +0.22% | Aug 31, 25 |
| 13 | State Street® SPDR® S&P® Biotech ETF | 332.28K (1.43%) | 5.00K Increased by +1.51% | Mar 31, 26 |
| 14 | Hood River Small-Cap Growth Instl | 329.78K (1.42%) | 256.42K Increased by +77.75% | Dec 31, 25 |
| 15 | Vanguard Small Cap Growth Index Inv | 329.15K (1.42%) | 790.00 Increased by +0.24% | Feb 28, 26 |
| 16 | First Trust NYSE Arca Biotech ETF | 308.50K (1.33%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 17 | T. Rowe Price Health Sciences | 292.72K (1.26%) | -25.37K Decreased by -8.67% | Jan 31, 26 |
| 18 | CS (Lux) Digital Health Equity SB USD | 290.00K (1.25%) | -40.00K Decreased by -13.79% | Mar 31, 24 |
| 19 | Vanguard Institutional Extnd Mkt Idx Tr | 281.26K (1.21%) | 2.69K Increased by +0.96% | Feb 28, 26 |
| 20 | Fidelity Small Cap Index | 239.95K (1.04%) | -3.01K Decreased by -1.25% | Jan 31, 26 |