| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | VR Adviser, LLC | 6.70M (24.01%) | 454.25K Increased by +6.78% | Mar 31, 25 |
| 2 | TANG CAPITAL MANAGEMENT LLC | 4.94M (17.70%) | 47.95K Increased by +0.97% | Mar 31, 25 |
| 3 | Suvretta Capital Management, LLC | 4.91M (17.59%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 4 | Vestal Point Capital LP | 4.75M (17.01%) | -18.71K Decreased by -0.39% | Mar 31, 25 |
| 5 | Capital World Investors | 3.18M (11.38%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 6 | BlackRock Inc | 3.15M (11.29%) | 287.74K Increased by +9.13% | Mar 31, 25 |
| 7 | Vanguard Group Inc | 2.41M (8.64%) | 113.80K Increased by +4.72% | Jun 30, 25 |
| 8 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.70M (6.08%) | 1.09M Increased by +63.97% | Mar 31, 25 |
| 9 | Woodline Partners LP | 1.62M (5.79%) | 329.07K Increased by +20.34% | Mar 31, 25 |
| 10 | Boxer Capital LLC | 1.59M (5.69%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | Boxer Capital Management, LLC | 1.59M (5.69%) | 1.59M Increased by +100.00% | Dec 31, 24 |
| 12 | Adage Capital Partners Gp LLC | 1.42M (5.08%) | -630.21K Decreased by -44.39% | Sep 30, 24 |
| 13 | Octagon Capital Advisors LP | 1.37M (4.91%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 14 | TCG Crossover Management, LLC | 1.16M (4.17%) | -2.23M Decreased by -191.87% | Mar 31, 24 |
| 15 | State Street Corp | 1.09M (3.92%) | -297.22K Decreased by -27.18% | Mar 31, 25 |
| 16 | First Turn Management LLC | 1.06M (3.79%) | -119.88K Decreased by -11.31% | Jun 30, 24 |
| 17 | Emerald Advisers, LLC | 1.04M (3.72%) | 139.86K Increased by +13.47% | Jun 30, 25 |
| 18 | Jefferies Financial Group Inc | 1.03M (3.69%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 19 | Great Point Partners LLC | 1.01M (3.63%) | -772.64K Decreased by -76.17% | Mar 31, 25 |
| 20 | StemPoint Capital LP | 992.80K (3.56%) | 992.80K Increased by +100.00% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 3.18M (11.38%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.40M (5.01%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 3 | Vanguard US Total Market Shares ETF | 1.20M (4.30%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 899.86K (3.22%) | -17.11K Decreased by -1.90% | Jul 31, 25 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 585.87K (2.10%) | 3.07K Increased by +0.52% | Jun 30, 25 |
| 6 | SPDR® S&P Biotech ETF | 571.42K (2.05%) | 17.09K Increased by +2.99% | Jul 31, 25 |
| 7 | International Biotechnology Ord | 554.96K (1.99%) | -114.19K Decreased by -20.58% | Jun 30, 25 |
| 8 | Fidelity Small Cap Index | 394.12K (1.41%) | -3.44K Decreased by -0.87% | May 31, 25 |
| 9 | MEDICAL BioHealth EUR Acc | 385.67K (1.38%) | 123.22K Increased by +31.95% | May 31, 25 |
| 10 | Emerald Growth A | 357.34K (1.28%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 11 | Candriam Eqs L Biotech C USD Cap | 350.00K (1.25%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 12 | iShares Russell 2000 Growth ETF | 333.10K (1.19%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 13 | APO Medical Opportunities R | 299.28K (1.07%) | 42.00K Increased by +14.03% | Jun 30, 25 |
| 14 | iShares Russell 2000 Value ETF | 286.26K (1.03%) | -380.00 Decreased by -0.13% | May 30, 24 |
| 15 | iShares Biotechnology ETF | 237.73K (0.85%) | 2.03K Increased by +0.85% | Jul 31, 25 |
| 16 | Fidelity® Small Cap Index | 233.79K (0.84%) | 5.15K Increased by +2.20% | Oct 31, 23 |
| 17 | Principal SmallCap Growth I Instl | 232.05K (0.83%) | -781.00 Decreased by -0.34% | Jun 30, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 230.31K (0.82%) | 1.02K Increased by +0.44% | Apr 30, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx SL Cl I | 230.31K (0.82%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 20 | Heptagon Driehaus US Micro Cap Eq C$ Acc | 226.30K (0.81%) | -3.98K Decreased by -1.76% | Aug 31, 24 |