| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | VR Adviser, LLC | 6.70M (23.02%) | 454.25K Increased by +6.78% | Mar 31, 25 |
| 2 | TANG CAPITAL MANAGEMENT LLC | 4.94M (16.97%) | 47.95K Increased by +0.97% | Mar 31, 25 |
| 3 | Suvretta Capital Management, LLC | 4.91M (16.87%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 4 | Vestal Point Capital LP | 4.75M (16.31%) | -18.71K Decreased by -0.39% | Mar 31, 25 |
| 5 | Capital World Investors | 3.18M (10.91%) | -196.48K Decreased by -6.18% | Mar 31, 25 |
| 6 | BlackRock Inc | 3.15M (10.82%) | 287.74K Increased by +9.13% | Mar 31, 25 |
| 7 | Vanguard Group Inc | 2.30M (7.89%) | 43.35K Increased by +1.89% | Mar 31, 25 |
| 8 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.70M (5.83%) | 1.09M Increased by +63.97% | Mar 31, 25 |
| 9 | Woodline Partners LP | 1.62M (5.55%) | 329.07K Increased by +20.34% | Mar 31, 25 |
| 10 | Boxer Capital LLC | 1.59M (5.46%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | Boxer Capital Management, LLC | 1.59M (5.46%) | 1.59M Increased by +100.00% | Dec 31, 24 |
| 12 | Adage Capital Partners Gp LLC | 1.42M (4.88%) | -630.21K Decreased by -44.39% | Sep 30, 24 |
| 13 | Octagon Capital Advisors LP | 1.37M (4.70%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 14 | TCG Crossover Management, LLC | 1.16M (3.99%) | -2.23M Decreased by -191.87% | Mar 31, 24 |
| 15 | State Street Corp | 1.09M (3.76%) | -297.22K Decreased by -27.18% | Mar 31, 25 |
| 16 | First Turn Management LLC | 1.06M (3.64%) | -119.88K Decreased by -11.31% | Jun 30, 24 |
| 17 | Jefferies Financial Group Inc | 1.03M (3.54%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 18 | Great Point Partners LLC | 1.01M (3.48%) | -772.64K Decreased by -76.17% | Mar 31, 25 |
| 19 | StemPoint Capital LP | 992.80K (3.41%) | 992.80K Increased by +100.00% | Dec 31, 24 |
| 20 | Citadel Advisors Llc | 928.50K (3.19%) | 81.90K Increased by +8.82% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 3.18M (10.91%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.40M (4.80%) | 0.00 Increased by 0.00% | May 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 1.20M (4.12%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 961.80K (3.30%) | 6.68K Increased by +0.69% | Jun 30, 25 |
| 5 | International Biotechnology Ord | 669.15K (2.30%) | -89.30K Decreased by -13.35% | May 31, 25 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 582.79K (2.00%) | 5.97K Increased by +1.03% | May 31, 25 |
| 7 | SPDR® S&P Biotech ETF | 572.59K (1.97%) | -9.35K Decreased by -1.63% | Jun 30, 25 |
| 8 | Fidelity Small Cap Index | 397.56K (1.37%) | 8.20K Increased by +2.06% | Apr 30, 25 |
| 9 | Emerald Growth A | 357.34K (1.23%) | 0.00 Increased by 0.00% | May 31, 25 |
| 10 | Candriam Eqs L Biotech C USD Cap | 350.00K (1.20%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 11 | iShares Russell 2000 Growth ETF | 335.99K (1.15%) | 828.00 Increased by +0.25% | Jun 30, 25 |
| 12 | iShares Russell 2000 Value ETF | 286.26K (0.98%) | -380.00 Decreased by -0.13% | May 30, 24 |
| 13 | MEDICAL BioHealth EUR Acc | 262.45K (0.90%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 14 | APO Medical Opportunities R | 257.28K (0.88%) | 61.12K Increased by +23.76% | May 31, 25 |
| 15 | iShares Biotechnology ETF | 237.68K (0.82%) | -858.00 Decreased by -0.36% | Jun 30, 25 |
| 16 | Fidelity® Small Cap Index | 233.79K (0.80%) | 5.15K Increased by +2.20% | Oct 31, 23 |
| 17 | Principal SmallCap Growth I Instl | 232.05K (0.80%) | -781.00 Decreased by -0.34% | Jun 30, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 230.31K (0.79%) | 1.02K Increased by +0.44% | Apr 30, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx SL Cl I | 230.31K (0.79%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 20 | Heptagon Driehaus US Micro Cap Eq C$ Acc | 226.30K (0.78%) | -3.98K Decreased by -1.76% | Aug 31, 24 |