| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | VR Adviser, LLC | 6.73M (17.61%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Frazier Life Sciences Management, L.P. | 5.04M (13.19%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Suvretta Capital Management, LLC | 4.77M (12.48%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 4 | TANG CAPITAL MANAGEMENT LLC | 4.57M (11.97%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 5 | BlackRock Inc | 3.75M (9.82%) | 628.03K Increased by +16.73% | Dec 31, 25 |
| 6 | Millennium Management LLC | 2.90M (7.58%) | 800.44K Increased by +27.63% | Dec 31, 25 |
| 7 | Capital World Investors | 2.81M (7.35%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 8 | Vanguard Group Inc | 2.51M (6.57%) | 7.90K Increased by +0.31% | Dec 31, 25 |
| 9 | SILVERARC CAPITAL MANAGEMENT, LLC | 2.43M (6.35%) | 1.06M Increased by +43.83% | Dec 31, 25 |
| 10 | Point72 Asset Management, L.P. | 2.28M (5.98%) | 2.28M Increased by +100.00% | Dec 31, 25 |
| 11 | Tudor Investment Corp Et AL | 2.00M (5.23%) | 2.00M Increased by +100.00% | Sep 30, 25 |
| 12 | Woodline Partners LP | 1.92M (5.03%) | 428.00 Increased by +0.02% | Dec 31, 25 |
| 13 | State Street Corp | 1.91M (5.00%) | 336.19K Increased by +17.59% | Dec 31, 25 |
| 14 | Vestal Point Capital LP | 1.89M (4.95%) | 1.14M Increased by +60.32% | Dec 31, 25 |
| 15 | Parkman Healthcare Partners LLC | 1.84M (4.80%) | 67.00K Increased by +3.65% | Mar 31, 26 |
| 16 | Kynam Capital Management, LP | 1.81M (4.74%) | 1.20M Increased by +66.53% | Dec 31, 25 |
| 17 | Boxer Capital LLC | 1.59M (4.16%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 18 | Boxer Capital Management, LLC | 1.59M (4.16%) | 1.59M Increased by +100.00% | Dec 31, 24 |
| 19 | Octagon Capital Advisors LP | 1.45M (3.79%) | 176.67K Increased by +12.18% | Mar 31, 26 |
| 20 | Adage Capital Partners Gp LLC | 1.42M (3.72%) | -630.21K Decreased by -44.39% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 2.81M (7.35%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.35M (3.53%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 3 | State Street® SPDR® S&P® Biotech ETF | 1.20M (3.15%) | -8.55K Decreased by -0.71% | Apr 30, 26 |
| 4 | Vanguard US Total Market Shares ETF | 1.20M (3.14%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | APO Medical Opportunities R | 1.17M (3.05%) | 866.80K Increased by +74.33% | Jul 31, 25 |
| 6 | MEDICAL BioHealth EUR Acc | 977.93K (2.56%) | -1.00K Decreased by -0.10% | Mar 31, 26 |
| 7 | iShares Russell 2000 ETF | 905.84K (2.37%) | 7.61K Increased by +0.84% | Apr 30, 26 |
| 8 | apo Medical Opportunities R | 774.91K (2.03%) | 36.00K Increased by +4.65% | Mar 31, 26 |
| 9 | International Biotechnology Ord | 746.05K (1.95%) | -425.70K Decreased by -57.06% | Feb 28, 26 |
| 10 | SPDR® S&P Biotech ETF | 571.42K (1.50%) | 1.27K Increased by +0.22% | Aug 31, 25 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 439.73K (1.15%) | 3.59K Increased by +0.82% | Mar 31, 26 |
| 12 | Biotech Growth Ord | 382.40K (1.00%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 13 | Fidelity Small Cap Index | 375.71K (0.98%) | 4.28K Increased by +1.14% | Feb 28, 26 |
| 14 | AZ InvestEd Ivy Small Cap Growth E | 353.28K (0.92%) | 353.28K Increased by +100.00% | Mar 31, 26 |
| 15 | SEB Läkemedelsfond | 351.31K (0.92%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 16 | Candriam Eqs L Biotech C USD Cap | 350.00K (0.92%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 17 | Principal SmallCap Growth I Instl | 321.42K (0.84%) | -692.00 Decreased by -0.22% | Mar 31, 26 |
| 18 | iShares Russell 2000 Growth ETF | 313.96K (0.82%) | 810.00 Increased by +0.26% | Apr 30, 26 |
| 19 | iShares Russell 2000 Value ETF | 286.26K (0.75%) | -380.00 Decreased by -0.13% | May 30, 24 |
| 20 | iShares Biotechnology ETF | 275.80K (0.72%) | 4.65K Increased by +1.68% | Apr 30, 26 |