| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | VR Adviser, LLC | 6.73M (22.77%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Frazier Life Sciences Management, L.P. | 5.04M (17.05%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Suvretta Capital Management, LLC | 4.77M (16.13%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 4 | TANG CAPITAL MANAGEMENT LLC | 4.57M (15.47%) | -468.27K Decreased by -10.24% | Dec 31, 25 |
| 5 | BlackRock Inc | 3.13M (10.58%) | -3.38K Decreased by -0.11% | Sep 30, 25 |
| 6 | Millennium Management LLC | 2.90M (9.80%) | 800.44K Increased by +27.63% | Dec 31, 25 |
| 7 | Capital World Investors | 2.81M (9.50%) | -369.00K Decreased by -13.14% | Dec 31, 25 |
| 8 | Vanguard Group Inc | 2.51M (8.49%) | 7.90K Increased by +0.31% | Dec 31, 25 |
| 9 | SILVERARC CAPITAL MANAGEMENT, LLC | 2.43M (8.21%) | 1.06M Increased by +43.83% | Dec 31, 25 |
| 10 | Point72 Asset Management, L.P. | 2.28M (7.73%) | 2.28M Increased by +100.00% | Dec 31, 25 |
| 11 | Tudor Investment Corp Et AL | 2.00M (6.77%) | 2.00M Increased by +100.00% | Sep 30, 25 |
| 12 | Woodline Partners LP | 1.92M (6.50%) | 428.00 Increased by +0.02% | Dec 31, 25 |
| 13 | Vestal Point Capital LP | 1.89M (6.39%) | 1.14M Increased by +60.32% | Dec 31, 25 |
| 14 | Kynam Capital Management, LP | 1.81M (6.13%) | 1.20M Increased by +66.53% | Dec 31, 25 |
| 15 | The Goldman Sachs Group Inc | 1.80M (6.09%) | 1.67M Increased by +92.53% | Sep 30, 25 |
| 16 | Parkman Healthcare Partners LLC | 1.77M (5.98%) | 33.51K Increased by +1.89% | Dec 31, 25 |
| 17 | Boxer Capital LLC | 1.59M (5.38%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 18 | Boxer Capital Management, LLC | 1.59M (5.38%) | 1.59M Increased by +100.00% | Dec 31, 24 |
| 19 | State Street Corp | 1.58M (5.33%) | 225.96K Increased by +14.34% | Sep 30, 25 |
| 20 | Adage Capital Partners Gp LLC | 1.42M (4.80%) | -630.21K Decreased by -44.39% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 2.81M (9.50%) | -369.00K Decreased by -13.14% | Dec 31, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.35M (4.57%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 1.20M (4.06%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | APO Medical Opportunities R | 1.17M (3.95%) | 866.80K Increased by +74.33% | Jul 31, 25 |
| 5 | State Street® SPDR® S&P® Biotech ETF | 1.08M (3.65%) | 16.20K Increased by +1.50% | Mar 31, 26 |
| 6 | MEDICAL BioHealth EUR Acc | 978.93K (3.31%) | -393.00 Decreased by -0.04% | Feb 28, 26 |
| 7 | iShares Russell 2000 ETF | 935.00K (3.16%) | -7.61K Decreased by -0.81% | Mar 31, 26 |
| 8 | International Biotechnology Ord | 746.05K (2.52%) | -425.70K Decreased by -57.06% | Feb 28, 26 |
| 9 | apo Medical Opportunities R | 738.91K (2.50%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 10 | SPDR® S&P Biotech ETF | 571.42K (1.93%) | 1.27K Increased by +0.22% | Aug 31, 25 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 436.14K (1.48%) | 5.88K Increased by +1.35% | Feb 28, 26 |
| 12 | Biotech Growth Ord | 382.40K (1.29%) | 312.20K Increased by +81.64% | Dec 31, 25 |
| 13 | Fidelity Small Cap Index | 371.43K (1.26%) | -4.62K Decreased by -1.24% | Jan 31, 26 |
| 14 | SEB Läkemedelsfond | 351.31K (1.19%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 15 | Candriam Eqs L Biotech C USD Cap | 350.00K (1.18%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 16 | Principal SmallCap Growth I Instl | 322.11K (1.09%) | -452.00 Decreased by -0.14% | Feb 28, 26 |
| 17 | iShares Russell 2000 Growth ETF | 313.55K (1.06%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 18 | iShares Russell 2000 Value ETF | 286.26K (0.97%) | -380.00 Decreased by -0.13% | May 30, 24 |
| 19 | iShares Biotechnology ETF | 277.49K (0.94%) | 576.00 Increased by +0.21% | Mar 31, 26 |
| 20 | Emerald Growth A | 260.12K (0.88%) | -40.00K Decreased by -15.38% | Feb 28, 26 |