| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | VR Adviser, LLC | 6.73M (22.47%) | 25.00K Increased by +0.37% | Jun 30, 25 |
| 2 | Suvretta Capital Management, LLC | 4.96M (16.54%) | 41.99K Increased by +0.85% | Jun 30, 25 |
| 3 | TANG CAPITAL MANAGEMENT LLC | 4.94M (16.50%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Vestal Point Capital LP | 4.67M (15.61%) | -76.29K Decreased by -1.63% | Jun 30, 25 |
| 5 | Capital World Investors | 3.18M (10.61%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 6 | BlackRock Inc | 3.13M (10.45%) | -22.24K Decreased by -0.71% | Jun 30, 25 |
| 7 | Vanguard Group Inc | 2.41M (8.06%) | 113.80K Increased by +4.72% | Jun 30, 25 |
| 8 | Woodline Partners LP | 1.92M (6.41%) | 303.19K Increased by +15.79% | Jun 30, 25 |
| 9 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.83M (6.12%) | 133.19K Increased by +7.27% | Jun 30, 25 |
| 10 | Boxer Capital LLC | 1.59M (5.31%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | Boxer Capital Management, LLC | 1.59M (5.31%) | 1.59M Increased by +100.00% | Dec 31, 24 |
| 12 | Adage Capital Partners Gp LLC | 1.42M (4.74%) | -630.21K Decreased by -44.39% | Sep 30, 24 |
| 13 | State Street Corp | 1.35M (4.51%) | 255.90K Increased by +18.96% | Jun 30, 25 |
| 14 | Octagon Capital Advisors LP | 1.27M (4.25%) | -96.67K Decreased by -7.59% | Jun 30, 25 |
| 15 | TCG Crossover Management, LLC | 1.16M (3.88%) | -2.23M Decreased by -191.87% | Mar 31, 24 |
| 16 | First Turn Management LLC | 1.06M (3.54%) | -119.88K Decreased by -11.31% | Jun 30, 24 |
| 17 | Emerald Advisers, LLC | 1.04M (3.47%) | 139.86K Increased by +13.47% | Jun 30, 25 |
| 18 | Jefferies Financial Group Inc | 1.03M (3.44%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 19 | Great Point Partners LLC | 1.01M (3.39%) | -772.64K Decreased by -76.17% | Mar 31, 25 |
| 20 | Ameriprise Financial Inc | 945.13K (3.16%) | 905.05K Increased by +95.76% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 3.18M (10.61%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.37M (4.57%) | -30.35K Decreased by -2.22% | Jul 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 1.20M (4.01%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | APO Medical Opportunities R | 1.17M (3.89%) | 866.80K Increased by +74.33% | Jul 31, 25 |
| 5 | iShares Russell 2000 ETF | 919.58K (3.07%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 6 | International Biotechnology Ord | 651.94K (2.18%) | 77.41K Increased by +11.87% | Aug 31, 25 |
| 7 | SPDR® S&P Biotech ETF | 571.42K (1.91%) | 1.27K Increased by +0.22% | Aug 31, 25 |
| 8 | MEDICAL BioHealth EUR Acc | 448.67K (1.50%) | 63.00K Increased by +14.04% | Jun 30, 25 |
| 9 | Vanguard Institutional Extnd Mkt Idx Tr | 408.90K (1.37%) | -176.97K Decreased by -43.28% | Jul 31, 25 |
| 10 | Emerald Growth A | 405.00K (1.35%) | 47.67K Increased by +11.77% | Jul 31, 25 |
| 11 | Fidelity Small Cap Index | 378.62K (1.26%) | -15.51K Decreased by -4.10% | Jun 30, 25 |
| 12 | Candriam Eqs L Biotech C USD Cap | 350.00K (1.17%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 13 | iShares Russell 2000 Growth ETF | 333.10K (1.11%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 14 | Principal SmallCap Growth I Instl | 288.67K (0.96%) | 56.61K Increased by +19.61% | Jul 31, 25 |
| 15 | iShares Russell 2000 Value ETF | 286.26K (0.96%) | -380.00 Decreased by -0.13% | May 30, 24 |
| 16 | Fidelity® Small Cap Index | 233.79K (0.78%) | 5.15K Increased by +2.20% | Oct 31, 23 |
| 17 | iShares Biotechnology ETF | 230.77K (0.77%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 230.31K (0.77%) | 1.02K Increased by +0.44% | Apr 30, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx SL Cl I | 230.31K (0.77%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 20 | Heptagon Driehaus US Micro Cap Eq C$ Acc | 226.30K (0.76%) | -3.98K Decreased by -1.76% | Aug 31, 24 |