| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | VR Adviser, LLC | 6.70M (23.08%) | 454.25K Increased by +6.78% | Mar 31, 25 |
| 2 | TANG CAPITAL MANAGEMENT LLC | 4.94M (17.01%) | 47.95K Increased by +0.97% | Mar 31, 25 |
| 3 | Suvretta Capital Management, LLC | 4.91M (16.91%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 4 | Vestal Point Capital LP | 4.75M (16.36%) | -18.71K Decreased by -0.39% | Mar 31, 25 |
| 5 | Capital World Investors | 3.18M (10.94%) | -196.48K Decreased by -6.18% | Mar 31, 25 |
| 6 | BlackRock Inc | 3.15M (10.85%) | 287.74K Increased by +9.13% | Mar 31, 25 |
| 7 | Vanguard Group Inc | 2.30M (7.91%) | 43.35K Increased by +1.89% | Mar 31, 25 |
| 8 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.70M (5.85%) | 1.09M Increased by +63.97% | Mar 31, 25 |
| 9 | Woodline Partners LP | 1.62M (5.57%) | 329.07K Increased by +20.34% | Mar 31, 25 |
| 10 | Boxer Capital LLC | 1.59M (5.47%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | Boxer Capital Management, LLC | 1.59M (5.47%) | 1.59M Increased by +100.00% | Dec 31, 24 |
| 12 | Adage Capital Partners Gp LLC | 1.42M (4.89%) | -630.21K Decreased by -44.39% | Sep 30, 24 |
| 13 | Octagon Capital Advisors LP | 1.37M (4.72%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 14 | TCG Crossover Management, LLC | 1.16M (4.00%) | -2.23M Decreased by -191.87% | Mar 31, 24 |
| 15 | State Street Corp | 1.09M (3.76%) | -297.22K Decreased by -27.18% | Mar 31, 25 |
| 16 | First Turn Management LLC | 1.06M (3.65%) | -119.88K Decreased by -11.31% | Jun 30, 24 |
| 17 | Jefferies Financial Group Inc | 1.03M (3.55%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 18 | Great Point Partners LLC | 1.01M (3.49%) | -772.64K Decreased by -76.17% | Mar 31, 25 |
| 19 | StemPoint Capital LP | 992.80K (3.42%) | 992.80K Increased by +100.00% | Dec 31, 24 |
| 20 | Citadel Advisors Llc | 928.50K (3.20%) | 81.90K Increased by +8.82% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 3.18M (10.94%) | -196.48K Decreased by -6.18% | Mar 31, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.40M (4.81%) | 0.00 Increased by 0.00% | May 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 1.20M (4.13%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 976.96K (3.36%) | 0.00 Increased by 0.00% | May 31, 25 |
| 5 | International Biotechnology Ord | 669.15K (2.30%) | -89.30K Decreased by -13.35% | May 31, 25 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 582.79K (2.01%) | 5.97K Increased by +1.03% | May 31, 25 |
| 7 | Fidelity Small Cap Index | 389.36K (1.34%) | 49.13K Increased by +12.62% | Mar 31, 25 |
| 8 | Emerald Growth A | 357.34K (1.23%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 9 | Candriam Eqs L Biotech C USD Cap | 350.00K (1.20%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 10 | iShares Russell 2000 Growth ETF | 338.48K (1.17%) | 0.00 Increased by 0.00% | May 31, 25 |
| 11 | SPDR® S&P Biotech ETF | 302.20K (1.04%) | 1.79K Increased by +0.59% | May 31, 25 |
| 12 | iShares Russell 2000 Value ETF | 286.26K (0.99%) | -380.00 Decreased by -0.13% | May 30, 24 |
| 13 | MEDICAL BioHealth EUR Acc | 262.45K (0.90%) | 262.45K Increased by +100.00% | Mar 31, 25 |
| 14 | Fidelity® Small Cap Index | 233.79K (0.80%) | 5.15K Increased by +2.20% | Oct 31, 23 |
| 15 | Principal SmallCap Growth I Instl | 232.83K (0.80%) | -444.00 Decreased by -0.19% | May 31, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx NL Cl C | 230.31K (0.79%) | 1.02K Increased by +0.44% | Apr 30, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 230.31K (0.79%) | 0.00 Increased by 0.00% | May 31, 25 |
| 18 | iShares Biotechnology ETF | 228.12K (0.79%) | 0.00 Increased by 0.00% | May 31, 25 |
| 19 | Heptagon Driehaus US Micro Cap Eq C$ Acc | 226.30K (0.78%) | -3.98K Decreased by -1.76% | Aug 31, 24 |
| 20 | Fidelity Extended Market Index | 203.35K (0.70%) | -1.94K Decreased by -0.96% | Apr 30, 25 |