| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Orbis Allan Gray Ltd | 14.42M (23.68%) | 3.34M Increased by +23.17% | Dec 31, 25 |
| 2 | AllianceBernstein L.P. | 10.95M (17.99%) | 291.54K Increased by +2.66% | Sep 30, 25 |
| 3 | Paradigm Biocapital Advisors LP | 7.04M (11.56%) | 3.22M Increased by +45.78% | Dec 31, 25 |
| 4 | Arrowstreet Capital Limited Partnership | 4.98M (8.18%) | 1.33M Increased by +26.82% | Dec 31, 25 |
| 5 | Citadel Advisors Llc | 3.57M (5.86%) | -857.47K Decreased by -24.02% | Jun 30, 25 |
| 6 | Renaissance Technologies Corp | 3.49M (5.74%) | 671.31K Increased by +19.22% | Dec 31, 25 |
| 7 | BlackRock Inc | 3.45M (5.67%) | 284.50K Increased by +8.25% | Sep 30, 25 |
| 8 | Harding Loevner L.P. | 3.37M (5.53%) | -114.34K Decreased by -3.39% | Dec 31, 25 |
| 9 | Macquarie Group Ltd | 3.25M (5.34%) | -347.52K Decreased by -10.69% | Sep 30, 23 |
| 10 | Capital Research & Mgmt Co - Division 3 | 2.57M (4.22%) | -1.85M Decreased by -71.99% | Dec 31, 24 |
| 11 | Wellington Management Company LLP | 2.31M (3.79%) | -670.00 Decreased by -0.03% | Sep 30, 24 |
| 12 | 1832 Asset Management L.P | 2.24M (3.68%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 13 | Two Sigma Advisers, LLC | 1.82M (2.99%) | -152.70K Decreased by -8.39% | Jun 30, 25 |
| 14 | Morgan Stanley - Brokerage Accounts | 1.67M (2.75%) | -1.02M Decreased by -61.06% | Sep 30, 25 |
| 15 | UBS Group AG | 1.44M (2.37%) | 1.38M Increased by +95.80% | Dec 31, 24 |
| 16 | First Trust Advisors L.P. | 1.34M (2.19%) | -352.12K Decreased by -26.37% | Dec 31, 25 |
| 17 | Cubist Systematic Strategies, LLC | 1.26M (2.07%) | 665.89K Increased by +52.93% | Mar 31, 25 |
| 18 | The Goldman Sachs Group Inc | 1.12M (1.84%) | 229.35K Increased by +20.50% | Sep 30, 25 |
| 19 | Pictet Asset Manangement SA | 1.10M (1.80%) | 1.10M Increased by +100.00% | Dec 31, 25 |
| 20 | FMR Inc | 1.06M (1.74%) | -62.37K Decreased by -5.90% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | AllianceBernstein US L/C Growth Eqty MF | 3.95M (6.48%) | -1.76M Decreased by -44.65% | Dec 30, 25 |
| 2 | iShares Biotechnology ETF | 3.68M (6.04%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 3 | Orbis SICAV Intl Eq Inv | 3.40M (5.58%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 4 | First Trust NYSE Arca Biotech ETF | 2.37M (3.90%) | 10.42K Increased by +0.44% | Feb 26, 26 |
| 5 | AB Large Cap Growth A | 2.34M (3.84%) | -348.23K Decreased by -14.90% | Jan 31, 26 |
| 6 | Vanguard Health Care Inv | 2.29M (3.75%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 7 | Delaware Ivy Mid Cap Growth A | 1.98M (3.25%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 8 | T. Rowe Price International Gr Eq SMA | 1.90M (3.12%) | 1.90M Increased by +100.00% | Dec 31, 24 |
| 9 | Orbis Global Equity Investor | 1.31M (2.15%) | 387.89K Increased by +29.69% | Sep 30, 25 |
| 10 | Xtrackers S&P 500 Swap ETF 1C | 1.02M (1.67%) | 1.02M Increased by +100.00% | Feb 28, 25 |
| 11 | AB US Large Cap Growth CT B | 1.01M (1.66%) | -14.88K Decreased by -1.48% | Jan 31, 26 |
| 12 | American Growth One D | 949.87K (1.56%) | -23.91K Decreased by -2.52% | Jan 31, 26 |
| 13 | AB American Growth AX USD | 943.61K (1.55%) | -248.47K Decreased by -26.33% | Jan 31, 26 |
| 14 | Dynamic Power Global Growth Class | 917.30K (1.51%) | -758.10K Decreased by -82.64% | Oct 31, 23 |
| 15 | Orbis SICAV Global Bal Instl Inv | 880.87K (1.45%) | 42.71K Increased by +4.85% | Jun 30, 25 |
| 16 | Pictet-Biotech P USD | 715.81K (1.18%) | -2.09K Decreased by -0.29% | Nov 30, 25 |
| 17 | Orbis Optimal (US$) Fund | 666.59K (1.09%) | 261.75K Increased by +39.27% | Jun 30, 25 |
| 18 | Franklin Innovation Composite | 500.00K (0.82%) | -100.00K Decreased by -20.00% | Sep 30, 23 |
| 19 | JOHCM Global Select I GBP | 469.96K (0.77%) | 469.96K Increased by +100.00% | Jan 31, 26 |
| 20 | Avantis International Equity ETF | 447.32K (0.73%) | 0.00 Increased by 0.00% | Feb 28, 26 |