| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Orbis Allan Gray Ltd | 14.42M (23.77%) | 3.34M Increased by +23.17% | Dec 31, 25 |
| 2 | AllianceBernstein L.P. | 10.88M (17.93%) | -76.82K Decreased by -0.71% | Dec 31, 25 |
| 3 | Paradigm Biocapital Advisors LP | 7.04M (11.61%) | 3.22M Increased by +45.78% | Dec 31, 25 |
| 4 | Arrowstreet Capital Limited Partnership | 4.98M (8.21%) | 1.33M Increased by +26.82% | Dec 31, 25 |
| 5 | BlackRock Inc | 4.59M (7.57%) | 1.14M Increased by +24.89% | Dec 31, 25 |
| 6 | Citadel Advisors Llc | 3.57M (5.88%) | -857.47K Decreased by -24.02% | Jun 30, 25 |
| 7 | Renaissance Technologies Corp | 3.49M (5.76%) | 671.31K Increased by +19.22% | Dec 31, 25 |
| 8 | Harding Loevner L.P. | 3.37M (5.56%) | -114.34K Decreased by -3.39% | Dec 31, 25 |
| 9 | Macquarie Group Ltd | 3.25M (5.36%) | -347.52K Decreased by -10.69% | Sep 30, 23 |
| 10 | Capital Research & Mgmt Co - Division 3 | 2.57M (4.24%) | -1.85M Decreased by -71.99% | Dec 31, 24 |
| 11 | Wellington Management Company LLP | 2.31M (3.80%) | -670.00 Decreased by -0.03% | Sep 30, 24 |
| 12 | 1832 Asset Management L.P | 2.24M (3.70%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 13 | Morgan Stanley - Brokerage Accounts | 1.83M (3.02%) | 159.87K Increased by +8.71% | Dec 31, 25 |
| 14 | Two Sigma Advisers, LLC | 1.82M (3.00%) | -152.70K Decreased by -8.39% | Jun 30, 25 |
| 15 | UBS Group AG | 1.44M (2.38%) | 1.38M Increased by +95.80% | Dec 31, 24 |
| 16 | First Trust Advisors L.P. | 1.34M (2.20%) | -352.12K Decreased by -26.37% | Dec 31, 25 |
| 17 | The Goldman Sachs Group Inc | 1.33M (2.20%) | 214.67K Increased by +16.10% | Dec 31, 25 |
| 18 | Cubist Systematic Strategies, LLC | 1.26M (2.07%) | 665.89K Increased by +52.93% | Mar 31, 25 |
| 19 | Pictet Asset Manangement SA | 1.08M (1.78%) | -21.08K Decreased by -1.96% | Mar 31, 26 |
| 20 | FMR Inc | 1.06M (1.74%) | -62.37K Decreased by -5.90% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | AllianceBernstein US L/C Growth Eqty MF | 3.95M (6.50%) | 0.00 Increased by 0.00% | Feb 27, 26 |
| 2 | iShares Biotechnology ETF | 3.49M (5.75%) | -29.61K Decreased by -0.85% | Apr 29, 26 |
| 3 | Orbis SICAV Intl Eq Inv | 3.09M (5.10%) | -306.17K Decreased by -9.90% | Feb 28, 26 |
| 4 | First Trust NYSE Arca Biotech ETF | 2.66M (4.39%) | -12.42K Decreased by -0.47% | Apr 30, 26 |
| 5 | Vanguard Health Care Inv | 2.29M (3.77%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | Delaware Ivy Mid Cap Growth A | 1.98M (3.26%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 7 | T. Rowe Price International Gr Eq SMA | 1.90M (3.13%) | 1.90M Increased by +100.00% | Dec 31, 24 |
| 8 | AB Large Cap Growth A | 1.85M (3.05%) | -172.84K Decreased by -9.35% | Mar 31, 26 |
| 9 | Orbis SICAV Global Bal Instl Inv | 1.41M (2.32%) | 528.30K Increased by +37.49% | Sep 30, 25 |
| 10 | Orbis Global Equity Investor | 1.31M (2.15%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 11 | Xtrackers S&P 500 Swap ETF 1C | 1.02M (1.68%) | 1.02M Increased by +100.00% | Feb 28, 25 |
| 12 | AB US Large Cap Growth CT B | 995.12K (1.64%) | -12.60K Decreased by -1.27% | Mar 31, 26 |
| 13 | American Growth One D | 949.87K (1.57%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 14 | AB American Growth AX USD | 949.32K (1.57%) | 907.00 Increased by +0.10% | Mar 31, 26 |
| 15 | Dynamic Power Global Growth Class | 917.30K (1.51%) | -758.10K Decreased by -82.64% | Oct 31, 23 |
| 16 | Pictet-Biotech P USD | 715.64K (1.18%) | 715.64K Increased by +100.00% | Jan 31, 26 |
| 17 | Orbis Optimal (US$) Fund | 693.66K (1.14%) | 27.07K Increased by +3.90% | Sep 30, 25 |
| 18 | Orbis OEIC Global Balanced Fixed Fee | 529.97K (0.87%) | 97.72K Increased by +18.44% | Oct 31, 25 |
| 19 | Federated Hermes Kaufmann R | 520.70K (0.86%) | 98.20K Increased by +18.86% | Mar 31, 26 |
| 20 | Franklin Innovation Composite | 500.00K (0.82%) | -100.00K Decreased by -20.00% | Sep 30, 23 |