| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 29.26M (11.66%) | 458.14K Increased by +1.57% | Dec 31, 24 |
| 2 | Wellington Management Company LLP | 28.46M (11.34%) | 4.50M Increased by +15.80% | Dec 31, 24 |
| 3 | BlackRock Inc | 27.91M (11.12%) | 1.80M Increased by +6.45% | Dec 31, 24 |
| 4 | Perceptive Advisors LLC | 24.25M (9.66%) | -3.81M Decreased by -15.72% | Dec 31, 24 |
| 5 | venBio Select Advisor LLC | 23.18M (9.24%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 6 | William Blair Investment Management, LLC | 15.60M (6.22%) | 14.74K Increased by +0.09% | Dec 31, 24 |
| 7 | State Street Corporation | 12.44M (4.96%) | -720.58K Decreased by -5.79% | Mar 31, 24 |
| 8 | State Street Corp | 10.36M (4.13%) | -609.52K Decreased by -5.88% | Dec 31, 24 |
| 9 | Citadel Advisors Llc | 8.24M (3.28%) | 4.61M Increased by +55.94% | Dec 31, 24 |
| 10 | Palo Alto Investors, LLC | 7.66M (3.05%) | -482.83K Decreased by -6.30% | Dec 31, 24 |
| 11 | JPMorgan Chase & Co | 7.21M (2.88%) | -18.63M Decreased by -258.18% | Dec 31, 24 |
| 12 | Redmile Group, LLC | 7.05M (2.81%) | -1.19M Decreased by -16.89% | Dec 31, 24 |
| 13 | Macquarie Group Ltd | 6.63M (2.64%) | -341.86K Decreased by -5.16% | Dec 31, 24 |
| 14 | Geode Capital Management, LLC | 6.61M (2.63%) | 11.06K Increased by +0.17% | Dec 31, 24 |
| 15 | Fiera Capital Corporation | 5.28M (2.10%) | 58.11K Increased by +1.10% | Jun 30, 24 |
| 16 | Pictet Asset Manangement SA | 4.22M (1.68%) | -2.55M Decreased by -60.51% | Jun 30, 24 |
| 17 | Morgan Stanley - Brokerage Accounts | 4.22M (1.68%) | -5.77M Decreased by -136.88% | Sep 30, 24 |
| 18 | Artal Group S A | 4.06M (1.62%) | -500.00K Decreased by -12.31% | Sep 30, 23 |
| 19 | Bank of America Corp | 4.04M (1.61%) | -4.49K Decreased by -0.11% | Dec 31, 24 |
| 20 | American Century Companies Inc | 3.90M (1.56%) | -2.23K Decreased by -0.06% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 20.89M (8.33%) | 2.30M Increased by +11.01% | Dec 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 9.40M (3.75%) | 7.43K Increased by +0.08% | Feb 28, 25 |
| 3 | iShares Russell 2000 ETF | 7.68M (3.06%) | -66.55K Decreased by -0.87% | Mar 31, 25 |
| 4 | Vanguard Small Cap Index | 7.63M (3.04%) | 6.21K Increased by +0.08% | Feb 28, 25 |
| 5 | Delaware US Small Cap Core Equity (SMA) | 5.30M (2.11%) | -62.03K Decreased by -1.17% | Mar 31, 24 |
| 6 | Macquarie US Small Cap Core Equity | 5.30M (2.11%) | -62.03K Decreased by -1.17% | Mar 31, 24 |
| 7 | Delaware Small Cap Core I | 5.13M (2.04%) | -31.80K Decreased by -0.62% | Sep 30, 24 |
| 8 | Macquarie Small Cap Core I | 4.79M (1.91%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 9 | Janus Henderson Opportunistic Alpha MA | 4.58M (1.83%) | 4.58M Increased by +99.99% | Jun 30, 24 |
| 10 | Janus Henderson US Opportunistic Alpha | 4.58M (1.83%) | -565.02K Decreased by -12.34% | Jun 30, 24 |
| 11 | Vanguard Small Cap Growth Index Inv | 4.28M (1.71%) | -31.82K Decreased by -0.74% | Feb 28, 25 |
| 12 | Vanguard Institutional Extnd Mkt Idx Tr | 4.07M (1.62%) | 5.79K Increased by +0.14% | Feb 28, 25 |
| 13 | American Century Heritage Inv | 3.49M (1.39%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 14 | American Century US Opport. Mid Cap Gr | 3.49M (1.39%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 15 | JPM Global Healthcare C (acc) USD | 3.27M (1.30%) | 0.00 Increased by 0.00% | Jan 31, 24 |
| 16 | SPDR® S&P Biotech ETF | 3.11M (1.24%) | -33.32K Decreased by -1.07% | Mar 31, 25 |
| 17 | JPM US Mid Cap Growth-Composite | 2.94M (1.17%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 18 | JPMorgan Mid Cap Growth I | 2.94M (1.17%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 19 | Pictet-Biotech P USD | 2.90M (1.15%) | -545.90K Decreased by -18.85% | Jul 31, 23 |
| 20 | Fidelity Small Cap Index | 2.89M (1.15%) | -54.21K Decreased by -1.87% | Jan 31, 25 |