| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management,Inc. | 20.41M (12.39%) | 17.60M Increased by +86.22% | Dec 31, 25 |
| 2 | HHG PLC | 13.89M (8.43%) | -857.78K Decreased by -6.18% | Dec 31, 25 |
| 3 | Vanguard Group Inc | 11.22M (6.81%) | 1.46M Increased by +12.97% | Dec 31, 25 |
| 4 | BlackRock Inc | 11.19M (6.79%) | 1.56M Increased by +13.90% | Dec 31, 25 |
| 5 | RA Capital Management, LLC | 9.71M (5.90%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 6 | Atlas Venture Life Science Advisors, LLC | 9.13M (5.54%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 7 | State Street Corp | 6.69M (4.06%) | 1.42M Increased by +21.27% | Dec 31, 25 |
| 8 | FMR Inc | 6.57M (3.99%) | 1.17M Increased by +17.78% | Dec 31, 25 |
| 9 | FCPM III SERVICES BV | 5.46M (3.32%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | Adage Capital Partners Gp LLC | 5.17M (3.14%) | 1.62M Increased by +31.28% | Dec 31, 25 |
| 11 | Orbis Allan Gray Ltd | 4.80M (2.91%) | 4.80M Increased by +100.00% | Dec 31, 25 |
| 12 | TCG Crossover Management, LLC | 4.62M (2.80%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 13 | State Street Corporation | 4.19M (2.55%) | 1.86M Increased by +44.27% | Mar 31, 24 |
| 14 | Siren, L.L.C. | 3.50M (2.13%) | -1.23M Decreased by -35.01% | Dec 31, 25 |
| 15 | Citadel Advisors Llc | 3.41M (2.07%) | 2.47M Increased by +72.35% | Sep 30, 25 |
| 16 | BRAIDWELL LP | 3.27M (1.99%) | -348.00K Decreased by -10.63% | Jun 30, 25 |
| 17 | Geode Capital Management, LLC | 3.26M (1.98%) | 395.82K Increased by +12.13% | Dec 31, 25 |
| 18 | JPMorgan Chase & Co | 3.25M (1.97%) | -296.44K Decreased by -9.11% | Mar 31, 26 |
| 19 | Armistice Capital, LLC | 3.25M (1.97%) | 185.71K Increased by +5.71% | Dec 31, 25 |
| 20 | Frazier Life Sciences Management, L.P. | 3.15M (1.91%) | 434.98K Increased by +13.80% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | T. Rowe Price Small-Cap Stock | 7.01M (4.26%) | 1.50M Increased by +21.33% | Mar 31, 26 |
| 2 | T. Rowe Price US Small-Cap Core Equity | 7.01M (4.26%) | 1.57M Increased by +22.45% | Mar 31, 26 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 4.65M (2.82%) | 29.74K Increased by +0.64% | Mar 31, 26 |
| 4 | T. Rowe Price Small-Cap Value | 4.63M (2.81%) | 301.67K Increased by +6.52% | Mar 31, 26 |
| 5 | State Street® SPDR® S&P® Biotech ETF | 3.84M (2.33%) | -27.29K Decreased by -0.71% | Apr 30, 26 |
| 6 | T. Rowe Price Instl Small-Cap Stock | 3.81M (2.31%) | 797.50K Increased by +20.93% | Mar 31, 26 |
| 7 | T. Rowe Price U.S. SC Core Eq Tr-D | 3.38M (2.05%) | 819.54K Increased by +24.25% | Mar 31, 26 |
| 8 | T. Rowe Price Capital Appreciation | 3.28M (1.99%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 9 | iShares Russell 2000 ETF | 3.13M (1.90%) | 26.37K Increased by +0.84% | Apr 30, 26 |
| 10 | T. Rowe Price U.S. SC Value Eq Tr-D | 3.00M (1.82%) | 1.43M Increased by +47.63% | Mar 31, 26 |
| 11 | Fidelity Growth Compy Commingled Pl S | 2.95M (1.79%) | 489.87K Increased by +16.63% | Mar 31, 26 |
| 12 | Vanguard US Total Market Shares ETF | 2.65M (1.61%) | 2.40K Increased by +0.09% | Sep 30, 24 |
| 13 | Janus Henderson Global Life Sciences | 2.53M (1.53%) | 7.97K Increased by +0.32% | Mar 31, 26 |
| 14 | Janus Henderson Global Life Sciences D | 2.51M (1.52%) | -7.05K Decreased by -0.28% | Jan 31, 26 |
| 15 | Janus Global Life Science AUSD | 2.33M (1.41%) | 153.63K Increased by +6.60% | Mar 31, 26 |
| 16 | Janus Henderson Glb Life Scn I2 USD | 2.33M (1.41%) | -36.26K Decreased by -1.56% | Mar 31, 26 |
| 17 | Fidelity Growth Company Fund | 2.20M (1.33%) | 440.90K Increased by +20.09% | Mar 31, 26 |
| 18 | Fidelity Select Biotechnology | 1.96M (1.19%) | 596.20K Increased by +30.35% | Mar 31, 26 |
| 19 | JPMorgan Small Cap Growth A | 1.94M (1.18%) | 496.51K Increased by +25.56% | Jul 31, 25 |
| 20 | Fidelity Growth Compy Commingled Pl O | 1.79M (1.08%) | 348.61K Increased by +19.51% | Aug 31, 24 |