| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 8.84M (12.39%) | -163.88K Decreased by -1.85% | Dec 31, 25 |
| 2 | Atlas Venture Life Science Advisors, LLC | 6.41M (8.99%) | -17.70K Decreased by -0.28% | Dec 31, 25 |
| 3 | Vanguard Group Inc | 6.28M (8.81%) | 101.05K Increased by +1.61% | Dec 31, 25 |
| 4 | RA Capital Management, LLC | 5.76M (8.07%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | FMR Inc | 5.72M (8.01%) | -4.38M Decreased by -76.63% | Dec 31, 25 |
| 6 | Vestal Point Capital LP | 5.20M (7.29%) | 2.52M Increased by +48.56% | Dec 31, 25 |
| 7 | State Street Corp | 4.29M (6.01%) | 1.05M Increased by +24.46% | Dec 31, 25 |
| 8 | Deerfield Management Co | 3.72M (5.22%) | -982.28K Decreased by -26.38% | Dec 31, 25 |
| 9 | Franklin Resources Inc | 3.48M (4.87%) | -620.60K Decreased by -17.85% | Sep 30, 25 |
| 10 | State Street Corporation | 3.38M (4.74%) | 444.18K Increased by +13.14% | Dec 31, 23 |
| 11 | Estuary Capital Management, LP | 3.33M (4.66%) | -389.93K Decreased by -11.72% | Mar 31, 25 |
| 12 | JPMorgan Chase & Co | 3.13M (4.39%) | 3.09M Increased by +98.61% | Mar 31, 26 |
| 13 | Fairmount Funds Management LLC | 3.10M (4.35%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 14 | Alyeska Investment Group, L.P. | 3.01M (4.22%) | -1.05M Decreased by -34.78% | Jun 30, 25 |
| 15 | Pictet Asset Manangement SA | 2.99M (4.19%) | 617.67K Increased by +20.65% | Dec 31, 25 |
| 16 | Viking Global Investors LP | 2.56M (3.59%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 17 | Canaan Partners XI LLC | 2.49M (3.49%) | -56.84K Decreased by -2.28% | Sep 30, 23 |
| 18 | UBS Group AG | 2.31M (3.23%) | 2.13M Increased by +92.59% | Mar 31, 26 |
| 19 | Partner Fund Management LP | 2.22M (3.12%) | 1.08M Increased by +48.43% | Sep 30, 23 |
| 20 | Wagonhound Investments, LP | 2.19M (3.07%) | -48.46K Decreased by -2.21% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 2.46M (3.45%) | 48.47K Increased by +1.97% | Mar 31, 26 |
| 2 | Vanguard US Total Market Shares ETF | 2.46M (3.45%) | 522.40K Increased by +21.25% | Sep 30, 24 |
| 3 | Polar Capital Biotech S Inc | 2.11M (2.96%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 4 | iShares Russell 2000 ETF | 1.90M (2.66%) | -15.51K Decreased by -0.82% | Mar 31, 26 |
| 5 | Pictet-Biotech P USD | 1.69M (2.37%) | 1.69M Increased by +100.00% | Jan 31, 26 |
| 6 | Franklin Small Cap Growth SMA | 1.61M (2.26%) | 1.61M Increased by +99.99% | Jun 30, 25 |
| 7 | Franklin US Small Cap Growth Equity | 1.61M (2.26%) | 130.60K Increased by +8.10% | Jun 30, 25 |
| 8 | Franklin Biotechnology Discv A(acc)USD | 1.55M (2.18%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 9 | Franklin Small Cap Growth Adv | 1.48M (2.08%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 10 | FIAM Small Cap Core Composite | 1.38M (1.94%) | -167.10K Decreased by -12.10% | Dec 31, 25 |
| 11 | Pictet Biotech | 1.37M (1.92%) | 1.37M Increased by +100.00% | Mar 31, 24 |
| 12 | SPDR® S&P Biotech ETF | 1.20M (1.69%) | 2.69K Increased by +0.22% | Aug 31, 25 |
| 13 | FIAM Small Cap Core CIT Cl B | 1.18M (1.65%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 14 | State Street® SPDR® S&P® Biotech ETF | 1.17M (1.63%) | 68.35K Increased by +5.87% | Mar 31, 26 |
| 15 | Fidelity Growth Compy Commingled Pl S | 1.15M (1.62%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 16 | US Small-Cap Growth II Equity Comp | 1.14M (1.60%) | -397.68K Decreased by -34.74% | Dec 31, 24 |
| 17 | Fidelity Select Health Care | 1.00M (1.40%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 18 | T. Rowe Price New Horizons | 980.72K (1.37%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 19 | Fidelity Stock Selector Small Cap | 936.00K (1.31%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 20 | Vanguard Small Cap Index | 896.39K (1.26%) | 20.55K Increased by +2.29% | Mar 31, 26 |