| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 24.69M (16.69%) | 9.29M Increased by +37.64% | Dec 31, 25 |
| 2 | VR Adviser, LLC | 15.56M (10.52%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | TANG CAPITAL MANAGEMENT LLC | 11.07M (7.48%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 4 | Perceptive Advisors LLC | 9.68M (6.54%) | 2.69M Increased by +27.75% | Sep 30, 25 |
| 5 | Kynam Capital Management, LP | 8.97M (6.06%) | 5.32M Increased by +59.33% | Dec 31, 25 |
| 6 | Vanguard Group Inc | 8.48M (5.73%) | -472.22K Decreased by -5.57% | Dec 31, 25 |
| 7 | COMMODORE CAPITAL LP | 7.69M (5.20%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | Franklin Resources Inc | 5.77M (3.90%) | 5.77M Increased by +100.00% | Jun 30, 25 |
| 9 | Bvf Inc | 5.23M (3.53%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | Point72 Asset Management, L.P. | 5.19M (3.51%) | 1.12M Increased by +21.60% | Dec 31, 25 |
| 11 | HHG PLC | 4.81M (3.25%) | -1.49M Decreased by -31.03% | Sep 30, 24 |
| 12 | Baker Bros Advisors LP | 4.25M (2.87%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 13 | ADAR1 Capital Management LLC | 4.18M (2.83%) | 137.35K Increased by +3.28% | Dec 31, 25 |
| 14 | Fairmount Funds Management LLC | 3.90M (2.63%) | 3.90M Increased by +100.00% | Jun 30, 25 |
| 15 | Balyasny Asset Management LLC | 3.87M (2.62%) | -40.88K Decreased by -1.06% | Dec 31, 25 |
| 16 | Financial Engines Advisors L.l.c. | 3.83M (2.59%) | 2.45M Increased by +63.92% | Dec 31, 25 |
| 17 | Orbimed Advisors, LLC | 3.53M (2.38%) | -4.94M Decreased by -140.00% | Dec 31, 25 |
| 18 | Prosight Management, LP | 3.52M (2.38%) | -412.89K Decreased by -11.74% | Jun 30, 25 |
| 19 | RTW INVESTMENTS, LLC | 3.46M (2.34%) | 3.46M Increased by +100.00% | Jun 30, 25 |
| 20 | Acadian Asset Management LLC | 3.23M (2.19%) | 3.20M Increased by +98.95% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 4.79M (3.24%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 4.51M (3.05%) | 67.83K Increased by +1.50% | Mar 31, 26 |
| 3 | Fidelity Select Health Care | 3.40M (2.30%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 4 | Fidelity Small Cap Growth | 3.28M (2.22%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 5 | Fidelity Stock Selector Small Cap | 3.22M (2.18%) | 87.80K Increased by +2.72% | Jan 31, 26 |
| 6 | Franklin Biotechnology Discv A(acc)USD | 2.92M (1.98%) | -800.28K Decreased by -27.37% | Jul 31, 25 |
| 7 | Fidelity Series Small Cap Opps | 2.53M (1.71%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 8 | FIAM Small Cap Core CIT Cl B | 2.49M (1.68%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 9 | FIAM Small Cap Core Composite | 2.49M (1.68%) | 1.40M Increased by +56.46% | Dec 31, 25 |
| 10 | Vanguard US Total Market Shares ETF | 2.46M (1.66%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | Fidelity Advisor Health Care I | 1.75M (1.18%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 12 | Biotech Growth Ord | 1.69M (1.14%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 13 | Fidelity Small Cap Growth K6 | 1.64M (1.11%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 14 | Franklin Biotechnology Discovery A | 1.57M (1.06%) | -470.89K Decreased by -29.92% | Jul 31, 25 |
| 15 | Vanguard Institutional Extnd Mkt Idx Tr | 1.46M (0.99%) | 16.00K Increased by +1.10% | Feb 28, 26 |
| 16 | Fidelity Advisor Biotechnology I | 1.35M (0.91%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 17 | Fidelity Select Biotechnology | 1.22M (0.83%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 18 | iShares Biotechnology ETF | 989.45K (0.67%) | 2.05K Increased by +0.21% | Mar 31, 26 |
| 19 | Fidelity Series Small Cap Core | 796.10K (0.54%) | -23.80K Decreased by -2.99% | Jan 31, 26 |
| 20 | Fidelity Extended Market Index | 700.35K (0.47%) | -2.54K Decreased by -0.36% | Feb 28, 26 |