| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 24.69M (13.25%) | 9.29M Increased by +37.64% | Dec 31, 25 |
| 2 | VR Adviser, LLC | 15.56M (8.35%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | TANG CAPITAL MANAGEMENT LLC | 11.07M (5.94%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 4 | Perceptive Advisors LLC | 9.68M (5.20%) | 2.69M Increased by +27.75% | Sep 30, 25 |
| 5 | Kynam Capital Management, LP | 8.97M (4.81%) | 5.32M Increased by +59.33% | Dec 31, 25 |
| 6 | Vanguard Group Inc | 8.48M (4.55%) | -472.22K Decreased by -5.57% | Dec 31, 25 |
| 7 | COMMODORE CAPITAL LP | 7.69M (4.13%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | Franklin Resources Inc | 5.77M (3.10%) | 5.77M Increased by +100.00% | Jun 30, 25 |
| 9 | Bvf Inc | 5.23M (2.81%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | Point72 Asset Management, L.P. | 5.19M (2.79%) | 1.12M Increased by +21.60% | Dec 31, 25 |
| 11 | State Street Corp | 5.14M (2.76%) | 4.50M Increased by +87.45% | Dec 31, 25 |
| 12 | Baker Bros Advisors LP | 4.98M (2.67%) | 725.00K Increased by +14.57% | Mar 31, 26 |
| 13 | HHG PLC | 4.81M (2.58%) | -1.49M Decreased by -31.03% | Sep 30, 24 |
| 14 | ADAR1 Capital Management LLC | 4.18M (2.25%) | 137.35K Increased by +3.28% | Dec 31, 25 |
| 15 | Fairmount Funds Management LLC | 3.90M (2.09%) | 3.90M Increased by +100.00% | Jun 30, 25 |
| 16 | Balyasny Asset Management LLC | 3.87M (2.08%) | -40.88K Decreased by -1.06% | Dec 31, 25 |
| 17 | Financial Engines Advisors L.l.c. | 3.83M (2.06%) | 2.45M Increased by +63.92% | Dec 31, 25 |
| 18 | BlackRock Inc | 3.67M (1.97%) | 1.29M Increased by +35.09% | Dec 31, 25 |
| 19 | Orbimed Advisors, LLC | 3.53M (1.89%) | -4.94M Decreased by -140.00% | Dec 31, 25 |
| 20 | Prosight Management, LP | 3.52M (1.89%) | -412.89K Decreased by -11.74% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 6.53M (3.51%) | 1.74M Increased by +26.62% | Mar 31, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 5.04M (2.71%) | -35.77K Decreased by -0.71% | Apr 30, 26 |
| 3 | Fidelity Select Health Care | 5.00M (2.68%) | 1.60M Increased by +32.00% | Mar 31, 26 |
| 4 | Fidelity Small Cap Growth | 3.28M (1.76%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 5 | Fidelity Select Biotechnology | 3.10M (1.67%) | 1.88M Increased by +60.63% | Mar 31, 26 |
| 6 | Franklin Biotechnology Discv A(acc)USD | 2.92M (1.57%) | -800.28K Decreased by -27.37% | Jul 31, 25 |
| 7 | Fidelity Advisor Health Care I | 2.50M (1.34%) | 750.00K Increased by +30.00% | Mar 31, 26 |
| 8 | FIAM Small Cap Core CIT Cl B | 2.49M (1.33%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 9 | FIAM Small Cap Core Composite | 2.49M (1.33%) | 1.40M Increased by +56.46% | Dec 31, 25 |
| 10 | Vanguard US Total Market Shares ETF | 2.46M (1.32%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | Fidelity Advisor Biotechnology I | 2.23M (1.20%) | 878.80K Increased by +39.42% | Mar 31, 26 |
| 12 | Strategic Advisers Fidelity US TtlStk | 2.04M (1.10%) | 1.59M Increased by +77.81% | Mar 31, 26 |
| 13 | Fidelity Stock Selector Small Cap | 2.04M (1.09%) | -1.18M Decreased by -58.06% | Feb 28, 26 |
| 14 | Vanguard Institutional Extnd Mkt Idx Tr | 1.99M (1.07%) | 534.56K Increased by +26.81% | Mar 31, 26 |
| 15 | Biotech Growth Ord | 1.69M (0.91%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 16 | Fidelity Small Cap Growth K6 | 1.64M (0.88%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 17 | Franklin Biotechnology Discovery A | 1.57M (0.84%) | -470.89K Decreased by -29.92% | Jul 31, 25 |
| 18 | Fidelity Series Small Cap Opps | 1.43M (0.77%) | -1.10M Decreased by -77.20% | Feb 28, 26 |
| 19 | iShares Biotechnology ETF | 1.25M (0.67%) | 286.69K Increased by +22.87% | Apr 30, 26 |
| 20 | Fidelity Extended Market Index | 950.75K (0.51%) | 250.40K Increased by +26.34% | Mar 31, 26 |