| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | VR Adviser, LLC | 13.97M (11.61%) | 13.97M Increased by +100.00% | Jun 30, 25 |
| 2 | TANG CAPITAL MANAGEMENT LLC | 11.07M (9.20%) | 4.35M Increased by +39.29% | Jun 30, 25 |
| 3 | Vanguard Group Inc | 9.38M (7.80%) | 4.26M Increased by +45.44% | Jun 30, 25 |
| 4 | FMR Inc | 9.24M (7.68%) | 9.13M Increased by +98.83% | Jun 30, 25 |
| 5 | Orbimed Advisors, LLC | 8.46M (7.03%) | 8.46M Increased by +100.00% | Jun 30, 25 |
| 6 | Point72 Asset Management, L.P. | 8.08M (6.72%) | 5.43M Increased by +67.22% | Jun 30, 25 |
| 7 | COMMODORE CAPITAL LP | 7.69M (6.40%) | 7.69M Increased by +100.00% | Jun 30, 25 |
| 8 | Perceptive Advisors LLC | 6.99M (5.81%) | 6.99M Increased by +100.00% | Jun 30, 25 |
| 9 | Franklin Resources Inc | 5.77M (4.80%) | 5.77M Increased by +100.00% | Jun 30, 25 |
| 10 | Vivo Capital, LLC | 5.77M (4.80%) | 5.77M Increased by +100.00% | Jun 30, 25 |
| 11 | Bvf Inc | 5.23M (4.35%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | HHG PLC | 4.81M (4.00%) | -1.49M Decreased by -31.03% | Sep 30, 24 |
| 13 | Fairmount Funds Management LLC | 3.90M (3.24%) | 3.90M Increased by +100.00% | Jun 30, 25 |
| 14 | Prosight Management, LP | 3.52M (2.92%) | -412.89K Decreased by -11.74% | Jun 30, 25 |
| 15 | Baker Bros Advisors LP | 3.48M (2.90%) | 3.48M Increased by +100.00% | Jun 30, 25 |
| 16 | RTW INVESTMENTS, LLC | 3.46M (2.88%) | 3.46M Increased by +100.00% | Jun 30, 25 |
| 17 | Acadian Asset Management LLC | 3.23M (2.69%) | 3.20M Increased by +98.95% | Mar 31, 25 |
| 18 | ADAR1 Capital Management LLC | 3.08M (2.56%) | 3.03M Increased by +98.47% | Jun 30, 25 |
| 19 | Adage Capital Partners Gp LLC | 3.00M (2.49%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 20 | Balyasny Asset Management LLC | 2.87M (2.38%) | 2.87M Increased by +100.00% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 4.95M (4.11%) | -109.73K Decreased by -2.22% | Jul 31, 25 |
| 2 | Fidelity Advisor Biotechnology I | 3.44M (2.86%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 3 | Franklin Biotechnology Discv A(acc)USD | 2.92M (2.43%) | -800.28K Decreased by -27.37% | Jul 31, 25 |
| 4 | Fidelity Stock Selector Small Cap | 2.72M (2.26%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 5 | Vanguard US Total Market Shares ETF | 2.46M (2.04%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | Fidelity Series Small Cap Opps | 2.39M (1.99%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 7 | Vanguard Institutional Extnd Mkt Idx Tr | 1.71M (1.42%) | -749.87K Decreased by -43.75% | Jul 31, 25 |
| 8 | Biotech Growth Ord | 1.69M (1.40%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 9 | Franklin Biotechnology Discovery A | 1.57M (1.31%) | -470.89K Decreased by -29.92% | Jul 31, 25 |
| 10 | Fidelity Extended Market Index | 855.47K (0.71%) | 4.58K Increased by +0.54% | Jul 31, 25 |
| 11 | Vanguard Explorer Inv | 820.46K (0.68%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 12 | Vanguard Strategic Small-Cap Equity Inv | 555.12K (0.46%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 13 | Acadian Global Small-Cap Equity CIT Cl A | 487.90K (0.41%) | 0.00 Increased by 0.00% | Mar 4, 25 |
| 14 | First Trust Dow Jones Sel MicroCap ETF | 484.74K (0.40%) | 0.00 Increased by 0.00% | Aug 28, 25 |
| 15 | Fidelity Blue Chip Growth | 378.62K (0.31%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 16 | Fidelity® Blue Chip Growth | 378.62K (0.31%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 17 | Invesco Technology S&P US Sel Sec ETF | 375.65K (0.31%) | 375.65K Increased by +100.00% | Jul 31, 25 |
| 18 | Alger LIfe Sciences Innovation Composite | 361.12K (0.30%) | 151.62K Increased by +41.99% | Jun 30, 25 |
| 19 | Fidelity® Extended Market Index | 350.14K (0.29%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 20 | Fidelity Total Market Index | 320.45K (0.27%) | -682.00 Decreased by -0.21% | Jul 31, 25 |