| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Medicxi Ventures Management (Jersey) Ltd | 19.96M (20.40%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | venBio Select Advisor LLC | 14.56M (14.87%) | 3.75M Increased by +25.75% | Dec 31, 25 |
| 3 | Adage Capital Partners Gp LLC | 11.28M (11.53%) | 1.25M Increased by +11.05% | Dec 31, 25 |
| 4 | Index Venture Life Associates VI Ltd | 9.96M (10.18%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 5 | Bvf Inc | 9.10M (9.30%) | -320.16K Decreased by -3.52% | Sep 30, 23 |
| 6 | FMR Inc | 8.96M (9.16%) | 2.68M Increased by +29.96% | Dec 31, 25 |
| 7 | General Atlantic Llc | 6.12M (6.25%) | -3.56M Decreased by -58.26% | Dec 31, 25 |
| 8 | HHG PLC | 5.41M (5.53%) | -1.12M Decreased by -20.79% | Sep 30, 25 |
| 9 | Farallon Capital Management, L.L.C. | 5.38M (5.49%) | 1.05M Increased by +19.45% | Dec 31, 25 |
| 10 | T. Rowe Price Associates, Inc. | 4.80M (4.91%) | -1.10M Decreased by -22.98% | Sep 30, 25 |
| 11 | TCG Crossover Management, LLC | 4.29M (4.38%) | 1.15M Increased by +26.83% | Dec 31, 25 |
| 12 | Siren, L.L.C. | 4.03M (4.12%) | 800.00K Increased by +19.86% | Dec 31, 25 |
| 13 | Vida Ventures Advisors, LLC | 3.93M (4.02%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 14 | EcoR1 Capital, LLC | 3.12M (3.18%) | 2.56M Increased by +82.34% | Dec 31, 25 |
| 15 | Perceptive Advisors LLC | 3.10M (3.17%) | 1.95M Increased by +63.01% | Sep 30, 25 |
| 16 | OUP Management Co., LLC | 2.94M (3.00%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 17 | COMMODORE CAPITAL LP | 2.85M (2.91%) | -448.29K Decreased by -15.73% | Sep 30, 25 |
| 18 | Point72 Asset Management, L.P. | 2.59M (2.65%) | 305.16K Increased by +11.78% | Jun 30, 25 |
| 19 | Franklin Resources Inc | 2.56M (2.61%) | 14.88K Increased by +0.58% | Sep 30, 25 |
| 20 | First Light Asset Management, LLC | 2.28M (2.33%) | -1.36M Decreased by -59.54% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity® Select Biotechnology | 2.79M (2.85%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 2 | Fidelity Select Biotechnology | 2.19M (2.24%) | -22.90K Decreased by -1.05% | Feb 28, 26 |
| 3 | T. Rowe Price Health Sciences | 1.89M (1.94%) | -300.66K Decreased by -15.88% | Jan 31, 26 |
| 4 | Fidelity Select Health Care | 1.65M (1.69%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 5 | Federated Hermes Kaufmann Growth | 1.24M (1.26%) | 350.70K Increased by +28.37% | Dec 31, 25 |
| 6 | Federated Hermes Kaufmann R | 1.24M (1.26%) | 350.70K Increased by +28.37% | Dec 31, 25 |
| 7 | Fidelity Contrafund | 1.23M (1.26%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 8 | American Funds SMALLCAP World A | 1.14M (1.16%) | 452.11K Increased by +39.77% | Dec 31, 25 |
| 9 | Federated Hermes Kaufmann Small Cap A | 1.08M (1.10%) | 239.70K Increased by +22.20% | Dec 31, 25 |
| 10 | Federated Hermes Kaufmann Small Cap Grow | 1.08M (1.10%) | 239.70K Increased by +22.20% | Dec 31, 25 |
| 11 | Franklin Biotechnology Discv A(acc)USD | 1.06M (1.09%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 12 | Polar Capital Biotech S Inc | 1.00M (1.02%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 13 | Janus Henderson US SMID Cap Growth MA | 953.94K (0.97%) | 953.86K Increased by +99.99% | Jun 30, 25 |
| 14 | Janus Henderson US SMID Cap Growth | 874.81K (0.89%) | -53.80K Decreased by -6.15% | Dec 31, 25 |
| 15 | American Century Small Cap Growth Inv | 864.16K (0.88%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 16 | American Century U.S. Small Cap Growth | 864.16K (0.88%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 17 | Janus Henderson Triton D | 853.85K (0.87%) | -20.96K Decreased by -2.45% | Jan 31, 26 |
| 18 | Fidelity Advisor Health Care I | 850.00K (0.87%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 19 | Strategic Advisers Fidelity US TtlStk | 800.00K (0.82%) | 60.00K Increased by +7.50% | Feb 28, 26 |
| 20 | Fidelity VIP Mid Cap Initial | 702.20K (0.72%) | 0.00 Increased by 0.00% | Feb 28, 26 |