| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 21.32M (17.37%) | 1.09M Increased by +5.13% | Dec 31, 25 |
| 2 | Vanguard Group Inc | 15.29M (12.46%) | -742.75K Decreased by -4.86% | Dec 31, 25 |
| 3 | venBio Select Advisor LLC | 10.63M (8.66%) | -275.00K Decreased by -2.59% | Dec 31, 25 |
| 4 | State Street Corporation | 6.56M (5.34%) | -264.41K Decreased by -4.03% | Mar 31, 24 |
| 5 | FMR Inc | 6.52M (5.31%) | 760.58K Increased by +11.66% | Dec 31, 25 |
| 6 | State Street Corp | 6.40M (5.22%) | 6.47K Increased by +0.10% | Dec 31, 25 |
| 7 | Geode Capital Management, LLC | 3.26M (2.66%) | 133.92K Increased by +4.10% | Dec 31, 25 |
| 8 | Artal Group S A | 3.19M (2.60%) | 152.72K Increased by +4.79% | Jun 30, 24 |
| 9 | Slate Path Capital LP | 2.52M (2.06%) | -2.46M Decreased by -97.42% | Dec 31, 25 |
| 10 | Amvescap Plc. | 2.31M (1.88%) | -136.73K Decreased by -5.93% | Dec 31, 23 |
| 11 | Baker Bros Advisors LP | 2.18M (1.77%) | 504.88K Increased by +23.21% | Dec 31, 25 |
| 12 | Goldman Sachs Group Inc | 2.12M (1.72%) | 373.65K Increased by +17.66% | Jun 30, 25 |
| 13 | Arrowstreet Capital Limited Partnership | 2.09M (1.70%) | 6.26K Increased by +0.30% | Dec 31, 25 |
| 14 | Fred Alger Management, LLC | 1.83M (1.49%) | 1.53M Increased by +83.26% | Dec 31, 25 |
| 15 | Deerfield Management Co | 1.83M (1.49%) | 839.95K Increased by +45.82% | Dec 31, 25 |
| 16 | Driehaus Capital Management LLC | 1.77M (1.44%) | -330.06K Decreased by -18.65% | Dec 31, 25 |
| 17 | UBS Asset Mgmt Americas Inc | 1.76M (1.43%) | -924.83K Decreased by -52.56% | Sep 30, 25 |
| 18 | NORGES BANK | 1.70M (1.39%) | -220.49K Decreased by -12.94% | Dec 31, 25 |
| 19 | The Goldman Sachs Group Inc | 1.68M (1.37%) | -96.36K Decreased by -5.74% | Dec 31, 25 |
| 20 | Credit Suisse First Boston (CSFB) | 1.63M (1.33%) | -118.83K Decreased by -7.31% | Mar 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | iShares Core S&P Small-Cap ETF | 7.47M (6.09%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 2 | iShares Core S&P Mid-Cap ETF | 4.73M (3.85%) | 4.17K Increased by +0.09% | Apr 29, 26 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 4.23M (3.44%) | 141.71K Increased by +3.35% | Mar 31, 26 |
| 4 | Vanguard US Total Market Shares ETF | 3.70M (3.02%) | 3.98K Increased by +0.11% | Sep 30, 24 |
| 5 | iShares Russell 2000 ETF | 3.16M (2.57%) | -6.48K Decreased by -0.21% | Apr 29, 26 |
| 6 | Vanguard Small Cap Index | 3.07M (2.50%) | 140.75K Increased by +4.58% | Mar 31, 26 |
| 7 | Fidelity Growth Compy Commingled Pl S | 2.77M (2.26%) | 27.60K Increased by +1.00% | Feb 28, 26 |
| 8 | Fidelity Growth Company Fund | 2.21M (1.80%) | 204.20K Increased by +9.22% | Mar 31, 26 |
| 9 | Invesco Global Multi Cap Growth | 1.80M (1.47%) | -196.30K Decreased by -10.88% | Dec 31, 23 |
| 10 | Invesco Global Opportunities A | 1.80M (1.47%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 11 | SPDR® S&P Biotech ETF | 1.73M (1.41%) | 3.86K Increased by +0.22% | Aug 31, 25 |
| 12 | Vanguard Small Cap Growth Index Inv | 1.72M (1.40%) | 91.86K Increased by +5.34% | Mar 31, 26 |
| 13 | State Street® SPDR® S&P® Biotech ETF | 1.63M (1.32%) | -16.07K Decreased by -0.99% | Apr 30, 26 |
| 14 | Vanguard Institutional Extnd Mkt Idx Tr | 1.57M (1.27%) | 58.55K Increased by +3.74% | Mar 31, 26 |
| 15 | Invesco S&P MidCap Momentum ETF | 1.52M (1.24%) | 3.59K Increased by +0.24% | Apr 30, 26 |
| 16 | Fidelity Small Cap Index | 1.30M (1.06%) | 14.12K Increased by +1.09% | Feb 28, 26 |
| 17 | American Funds SMALLCAP World A | 1.28M (1.04%) | 454.63K Increased by +35.59% | Dec 31, 23 |
| 18 | Fidelity Growth Compy Commingled Pl O | 1.21M (0.99%) | 127.90K Increased by +10.55% | Aug 31, 24 |
| 19 | CS (Lux) Digital Health Equity SB USD | 1.20M (0.98%) | 50.00K Increased by +4.17% | Mar 31, 24 |
| 20 | UBS (Lux) Digital Health Equity SB USD | 1.20M (0.98%) | 0.00 Increased by 0.00% | Feb 28, 25 |