| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 4.69M (12.05%) | 0 Increased by 0% | Sep 30, 23 |
| 2 | Great Point Partners LLC | 3.7M (9.52%) | 624.8K Increased by +16.87% | Dec 31, 23 |
| 3 | BlackRock Inc | 3.06M (7.86%) | 706.58K Increased by +23.1% | Dec 31, 23 |
| 4 | Cormorant Asset Management, LLC | 2.55M (6.55%) | 650K Increased by +25.49% | Dec 31, 23 |
| 5 | Orbimed Advisors, LLC | 2.54M (6.51%) | -1.55M Decreased by -60.99% | Dec 31, 23 |
| 6 | Paradigm Biocapital Advisors LP | 2.42M (6.22%) | -2.22K Decreased by -0.09% | Sep 30, 23 |
| 7 | T. Rowe Price Associates, Inc. | 1.69M (4.34%) | 290.83K Increased by +17.24% | Dec 31, 23 |
| 8 | Vanguard Group Inc | 1.47M (3.79%) | 70.91K Increased by +4.81% | Sep 30, 23 |
| 9 | COMMODORE CAPITAL LP | 1.32M (3.4%) | 0 Increased by 0% | Sep 30, 23 |
| 10 | Franklin Resources Inc | 1.22M (3.14%) | 1.22M Increased by +100% | Dec 31, 23 |
| 11 | Artal Group S A | 1.19M (3.07%) | 0 Increased by 0% | Sep 30, 23 |
| 12 | Woodline Partners LP | 1M (2.57%) | -38.67K Decreased by -3.87% | Dec 31, 23 |
| 13 | Vivo Capital, LLC | 914.91K (2.35%) | 0 Increased by 0% | Sep 30, 23 |
| 14 | Octagon Capital Advisors LP | 750K (1.93%) | 0 Increased by 0% | Sep 30, 23 |
| 15 | Adage Capital Partners Gp LLC | 714.59K (1.84%) | 714.59K Increased by +100% | Dec 31, 23 |
| 16 | Ghost Tree Capital, LLC | 664.13K (1.71%) | 316.7K Increased by +47.69% | Sep 30, 23 |
| 17 | Avidity Partners Management LP | 657.28K (1.69%) | -401.22K Decreased by -61.04% | Sep 30, 23 |
| 18 | Geode Capital Management, LLC | 628.92K (1.62%) | 10.95K Increased by +1.74% | Sep 30, 23 |
| 19 | State Street Corporation | 605.54K (1.56%) | 32.7K Increased by +5.4% | Sep 30, 23 |
| 20 | HHG PLC | 583.24K (1.5%) | 583.24K Increased by +100% | Dec 31, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.27M (3.27%) | 0 Increased by 0% | Jan 31, 24 |
| 2 | T. Rowe Price New Horizons | 1.11M (2.84%) | 237.72K Increased by +21.5% | Dec 31, 23 |
| 3 | US Small-Cap Growth II Equity Comp | 1.11M (2.84%) | 237.72K Increased by +21.5% | Dec 31, 23 |
| 4 | Franklin Biotechnology Discv A(acc)USD | 824.6K (2.12%) | 0 Increased by 0% | Jan 31, 24 |
| 5 | iShares Russell 2000 ETF | 788.41K (2.03%) | -129 Decreased by -0.02% | Feb 29, 24 |
| 6 | SPDR® S&P Biotech ETF | 753.4K (1.94%) | 14.1K Increased by +1.87% | Feb 29, 24 |
| 7 | Vanguard Institutional Extnd Mkt Idx Tr | 573.24K (1.47%) | 219 Increased by +0.04% | Jan 31, 24 |
| 8 | Candriam Eqs L Biotech C USD Cap | 490K (1.26%) | 20K Increased by +4.08% | Jan 31, 24 |
| 9 | Franklin Biotechnology Discovery A | 387.37K (1%) | 0 Increased by 0% | Jan 31, 24 |
| 10 | Fidelity Small Cap Index | 324.79K (0.83%) | 11.69K Increased by +3.6% | Dec 31, 23 |
| 11 | Fidelity® Small Cap Index | 308.42K (0.79%) | 9K Increased by +2.92% | Oct 31, 23 |
| 12 | iShares Biotechnology ETF | 278.83K (0.72%) | -1.25K Decreased by -0.45% | Feb 29, 24 |
| 13 | Fidelity Select Biotechnology | 220.8K (0.57%) | 0 Increased by 0% | Jan 31, 24 |
| 14 | Fidelity® Select Biotechnology | 220.8K (0.57%) | 98.7K Increased by +44.7% | Nov 30, 23 |
| 15 | Fidelity Extended Market Index | 220.25K (0.57%) | 2.32K Increased by +1.05% | Jan 31, 24 |
| 16 | T. Rowe Price Health Sciences | 213.3K (0.55%) | 213.3K Increased by +100% | Dec 31, 23 |
| 17 | State St Russell Sm/Mid Cp® Indx NL Cl C | 192.5K (0.49%) | 0 Increased by 0% | Jan 31, 24 |
| 18 | Schwab US Small-Cap ETF™ | 184.79K (0.47%) | 0 Increased by 0% | Feb 29, 24 |
| 19 | T. Rowe Price New Horizons Tr-Z | 176.24K (0.45%) | 32.42K Increased by +18.4% | Dec 31, 23 |
| 20 | Invesco Dorsey Wright SmallCap Momt ETF | 168.9K (0.43%) | 4.22K Increased by +2.5% | Feb 29, 24 |