| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management,Inc. | 16.21M (37.74%) | 9.86M Increased by +60.82% | Dec 31, 25 |
| 2 | Paradigm Biocapital Advisors LP | 5.72M (13.32%) | 1.07M Increased by +18.78% | Dec 31, 25 |
| 3 | Vanguard Group Inc | 4.08M (9.50%) | 174.43K Increased by +4.27% | Dec 31, 25 |
| 4 | FMR Inc | 3.56M (8.30%) | -2.20M Decreased by -61.67% | Dec 31, 25 |
| 5 | BlackRock Inc | 3.55M (8.26%) | 160.89K Increased by +4.53% | Dec 31, 25 |
| 6 | NEA Management Company, LLC | 3.05M (7.09%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 7 | Vestal Point Capital LP | 2.92M (6.81%) | 1.68M Increased by +57.26% | Dec 31, 25 |
| 8 | Perceptive Advisors LLC | 2.47M (5.75%) | -9.65K Decreased by -0.39% | Sep 30, 25 |
| 9 | SR ONE CAPITAL MANAGEMENT, LP | 2.35M (5.46%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | State Street Corp | 2.00M (4.65%) | 472.48K Increased by +23.64% | Dec 31, 25 |
| 11 | State Street Corporation | 1.77M (4.13%) | -240.41K Decreased by -13.55% | Dec 31, 23 |
| 12 | T. Rowe Price Associates, Inc. | 1.61M (3.75%) | 346.75K Increased by +21.53% | Dec 31, 25 |
| 13 | Citadel Advisors Llc | 1.50M (3.49%) | 478.77K Increased by +31.91% | Dec 31, 25 |
| 14 | JPMorgan Chase & Co | 1.45M (3.39%) | -310.53K Decreased by -21.35% | Dec 31, 25 |
| 15 | RA Capital Management, LLC | 1.27M (2.95%) | -1.77M Decreased by -139.63% | Dec 31, 25 |
| 16 | Novo A/S | 1.07M (2.50%) | 75.00K Increased by +6.98% | Sep 30, 23 |
| 17 | AJU IB Investment Co Ltd | 1.05M (2.44%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 18 | Geode Capital Management, LLC | 958.06K (2.23%) | 31.75K Increased by +3.31% | Dec 31, 25 |
| 19 | HHG PLC | 919.58K (2.14%) | -94.34K Decreased by -10.26% | Dec 31, 25 |
| 20 | Capital World Investors | 783.01K (1.82%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.85M (4.31%) | -15.80K Decreased by -0.85% | Mar 31, 26 |
| 2 | T. Rowe Price Capital Appreciation | 1.38M (3.21%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 3 | Vanguard Small Cap Index | 1.35M (3.14%) | 693.89K Increased by +51.40% | Mar 31, 26 |
| 4 | T. Rowe Price US Mid-Cap Growth Equity | 1.21M (2.81%) | 428.90K Increased by +35.50% | Dec 31, 25 |
| 5 | T. Rowe Price Mid-Cap Growth | 1.21M (2.81%) | -1.00K Decreased by -0.08% | Jan 31, 26 |
| 6 | Fidelity® Select Biotechnology | 1.19M (2.78%) | -167.40K Decreased by -14.04% | Nov 30, 23 |
| 7 | iShares Russell 2000 ETF | 936.94K (2.18%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 8 | T. Rowe Price US Small-Cap Core Equity | 917.84K (2.14%) | 200.31K Increased by +21.82% | Dec 31, 25 |
| 9 | T. Rowe Price Small-Cap Stock | 916.45K (2.13%) | -1.39K Decreased by -0.15% | Jan 31, 26 |
| 10 | American Funds SMALLCAP World A | 783.01K (1.82%) | 73.64K Increased by +9.40% | Jun 30, 25 |
| 11 | State Street® SPDR® S&P® Biotech ETF | 775.24K (1.80%) | 45.62K Increased by +5.88% | Mar 31, 26 |
| 12 | Vanguard Small Cap Growth Index Inv | 755.92K (1.76%) | 390.66K Increased by +51.68% | Mar 31, 26 |
| 13 | SPDR® S&P Biotech ETF | 688.11K (1.60%) | 1.53K Increased by +0.22% | Aug 31, 25 |
| 14 | T. Rowe Price Small-Cap Value | 682.86K (1.59%) | -935.00 Decreased by -0.14% | Jan 31, 26 |
| 15 | JPMorgan Mid Cap Growth I | 624.34K (1.45%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 16 | T. Rowe Price Health Sciences | 603.34K (1.40%) | 221.35K Increased by +36.69% | Jan 31, 26 |
| 17 | Fidelity Growth Compy Commingled Pl S | 596.40K (1.39%) | -360.84K Decreased by -60.50% | Dec 31, 25 |
| 18 | Fidelity Growth Company Fund | 536.04K (1.25%) | -219.03K Decreased by -40.86% | Dec 31, 25 |
| 19 | T. Rowe Price Instl Small-Cap Stock | 496.38K (1.16%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 20 | Vanguard Institutional Extnd Mkt Idx Tr | 484.35K (1.13%) | 11.55K Increased by +2.38% | Mar 31, 26 |