| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Bvf Inc | 19.82M (51.33%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Redmile Group, LLC | 1.03M (2.68%) | -659.87K Decreased by -63.80% | Dec 31, 24 |
| 3 | Wells Fargo & Co | 1.01M (2.62%) | -14.09K Decreased by -1.39% | Sep 30, 25 |
| 4 | Millennium Management LLC | 933.34K (2.42%) | 38.81K Increased by +4.16% | Dec 31, 25 |
| 5 | Avidity Partners Management LP | 825.00K (2.14%) | -3.65M Decreased by -441.82% | Jun 30, 24 |
| 6 | Junked Platinum Investment Management Ltd | 739.34K (1.91%) | -212.73K Decreased by -28.77% | Mar 31, 25 |
| 7 | Renaissance Technologies Corp | 668.87K (1.73%) | -101.55K Decreased by -15.18% | Dec 31, 25 |
| 8 | StemPoint Capital LP | 434.59K (1.13%) | 434.59K Increased by +100.00% | Dec 31, 23 |
| 9 | Acadian Asset Management LLC | 413.24K (1.07%) | 413.24K Increased by +100.00% | Sep 30, 25 |
| 10 | BlackRock Inc | 411.85K (1.07%) | 541.00 Increased by +0.13% | Sep 30, 25 |
| 11 | Arrowstreet Capital Limited Partnership | 375.62K (0.97%) | 375.62K Increased by +100.00% | Dec 31, 25 |
| 12 | Northern Trust Corp | 281.95K (0.73%) | -99.40K Decreased by -35.25% | Sep 30, 25 |
| 13 | Deutsche Bank AG | 253.38K (0.66%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 14 | Assenagon Asset Management SA | 223.88K (0.58%) | -215.85K Decreased by -96.41% | Sep 30, 24 |
| 15 | Dimensional Fund Advisors, Inc. | 213.46K (0.55%) | 36.35K Increased by +17.03% | Dec 31, 25 |
| 16 | Marshall Wace Asset Management Ltd | 186.71K (0.48%) | 186.71K Increased by +100.00% | Dec 31, 25 |
| 17 | Susquehanna International Group, LLP | 147.63K (0.38%) | 125.78K Increased by +85.21% | Dec 31, 25 |
| 18 | LANDSCAPE CAPITAL MANAGEMENT,LLC | 117.42K (0.30%) | 117.42K Increased by +100.00% | Mar 31, 24 |
| 19 | Dauntless Investment Group, LLC | 115.68K (0.30%) | 115.68K Increased by +100.00% | Dec 31, 25 |
| 20 | Handelsbanken Fonder AB | 105.00K (0.27%) | -25.00K Decreased by -23.81% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | iShares Biotechnology ETF | 463.72K (1.20%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | BlackRock Health Sciences Term Trust | 258.71K (0.67%) | -370.12K Decreased by -143.06% | Mar 31, 25 |
| 3 | DWS ESG Biotech LC | 253.39K (0.66%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 4 | BlackRock Health Sciences Opps Inv A | 115.87K (0.30%) | -242.44K Decreased by -209.24% | Apr 30, 25 |
| 5 | Monega ARIAD Innovation R | 92.36K (0.24%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 6 | ALPS Medical Breakthroughs ETF | 79.77K (0.21%) | 628.00 Increased by +0.79% | Nov 29, 24 |
| 7 | iShares Nasdaq US Biotech ETF USD Acc | 74.79K (0.19%) | 20.79K Increased by +27.80% | Feb 28, 26 |
| 8 | Fidelity Nasdaq Composite Index | 63.60K (0.16%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 9 | BlackRock Health Sciences | 62.90K (0.16%) | -15.28K Decreased by -24.29% | Dec 31, 24 |
| 10 | Blackrock Health Sciences Trust | 62.90K (0.16%) | -15.28K Decreased by -24.29% | Dec 31, 24 |
| 11 | Dimensional US Small Cap ETF | 55.77K (0.14%) | 218.00 Increased by +0.39% | Feb 27, 26 |
| 12 | DFA US Small Cap I | 36.80K (0.10%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 13 | Top Class Healthcare FI | 36.00K (0.09%) | 6.00K Increased by +16.67% | Dec 31, 25 |
| 14 | DFA US Targeted Value I | 29.85K (0.08%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 15 | DFA US Micro Cap I | 28.41K (0.07%) | 17.88K Increased by +62.94% | Jan 31, 26 |
| 16 | Fidelity Select Biotechnology | 27.20K (0.07%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 17 | China Universal NASDAQ Bio-Tch ETF(QDII) | 20.17K (0.05%) | -803.00 Decreased by -3.98% | Jun 30, 25 |
| 18 | Pacific Select Health Sciences I | 17.65K (0.05%) | -4.62K Decreased by -26.18% | Mar 31, 25 |
| 19 | Acadian All Ctry Wld ex US SCap Eq CL A | 15.88K (0.04%) | 0.00 Increased by 0.00% | Mar 4, 25 |
| 20 | Acadian All Ctry Wld ex US SCap Eq CL B | 15.88K (0.04%) | 0.00 Increased by 0.00% | Mar 4, 25 |