| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 22.97M (59.83%) | 5.71M Increased by +24.86% | Jun 30, 25 |
| 2 | Rubric Capital Management LP | 4.34M (11.30%) | 421.11K Increased by +9.71% | Mar 31, 25 |
| 3 | Bvf Inc | 4.31M (11.22%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Redmile Group, LLC | 4.15M (10.81%) | -638.32K Decreased by -15.38% | Jun 30, 25 |
| 5 | BlackRock Inc | 4.09M (10.65%) | -95.53K Decreased by -2.34% | Mar 31, 25 |
| 6 | Morgan Stanley - Brokerage Accounts | 4.07M (10.61%) | -127.97K Decreased by -3.14% | Mar 31, 25 |
| 7 | Vanguard Group Inc | 2.46M (6.42%) | 697.65K Increased by +28.31% | Jun 30, 25 |
| 8 | UBS Asset Mgmt Americas Inc | 2.46M (6.41%) | -1.42M Decreased by -57.75% | Jun 30, 25 |
| 9 | BNP Paribas Investment Partners SA | 2.20M (5.72%) | 60.23K Increased by +2.74% | Mar 31, 25 |
| 10 | Credit Suisse First Boston (CSFB) | 1.90M (4.94%) | -407.86K Decreased by -21.51% | Mar 31, 24 |
| 11 | Deutsche Bank AG | 1.55M (4.04%) | 5.84K Increased by +0.38% | Mar 31, 25 |
| 12 | Blackstone Inc | 1.38M (3.60%) | 812.87K Increased by +58.79% | Mar 31, 25 |
| 13 | Farallon Capital Management, L.L.C. | 1.33M (3.46%) | -31.03K Decreased by -2.33% | Dec 31, 24 |
| 14 | Perceptive Advisors LLC | 1.28M (3.32%) | -589.40K Decreased by -46.22% | Jun 30, 25 |
| 15 | Dimensional Fund Advisors, Inc. | 1.19M (3.11%) | 112.97K Increased by +9.47% | Jun 30, 25 |
| 16 | Nextech Invest AG | 1.11M (2.90%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 17 | Nextech Invest, Ltd. | 1.11M (2.90%) | 1.11M Increased by +100.00% | Mar 31, 25 |
| 18 | TANG CAPITAL MANAGEMENT LLC | 1.10M (2.87%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 19 | State Street Corp | 1.09M (2.83%) | 172.00 Increased by +0.02% | Mar 31, 25 |
| 20 | Prosight Management, LP | 957.23K (2.49%) | 137.23K Increased by +14.34% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard US Total Market Shares ETF | 2.24M (5.83%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 2 | CS (Lux) Digital Health Equity SB USD | 2.20M (5.73%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 3 | HBM Healthcare Investments AG Ord | 2.00M (5.20%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.85M (4.81%) | -40.86K Decreased by -2.21% | Jul 31, 25 |
| 5 | iShares Russell 2000 ETF | 1.19M (3.10%) | -22.68K Decreased by -1.90% | Jul 31, 25 |
| 6 | BNP Paribas US Small Cap ClassicC | 1.09M (2.83%) | 16.35K Increased by +1.51% | Jun 30, 25 |
| 7 | UBS (Lux) Digital Health Equity SB USD | 1.08M (2.81%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 8 | BNP Paribas US Small Cap Classic R | 1.07M (2.79%) | -21.54K Decreased by -2.01% | May 31, 25 |
| 9 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 844.70K (2.20%) | -168.40K Decreased by -19.94% | Jun 30, 25 |
| 10 | BNP Paribas Health Cr Innovtr Cl Cap | 796.46K (2.07%) | 148.00 Increased by +0.02% | Jun 30, 25 |
| 11 | Xtrackers S&P 500 Swap ETF 1C | 774.42K (2.02%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 12 | Xtrackers S&P 500 2xLev Dly Swap ETF 1C | 632.16K (1.65%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 13 | Fidelity Small Cap Index | 551.33K (1.44%) | -2.77K Decreased by -0.50% | May 31, 25 |
| 14 | Fidelity® Small Cap Index | 516.34K (1.34%) | 13.80K Increased by +2.67% | Oct 31, 23 |
| 15 | iShares Russell 2000 Value ETF | 497.32K (1.30%) | 0.00 Increased by 0.00% | May 31, 25 |
| 16 | Nuveen Quant Small Cap Equity R6 | 471.87K (1.23%) | 97.48K Increased by +20.66% | Jun 30, 25 |
| 17 | iShares Russell 2000 Growth ETF | 435.07K (1.13%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 18 | iShares Biotechnology ETF | 417.69K (1.09%) | 3.57K Increased by +0.85% | Jul 31, 25 |
| 19 | Bridgeway Omni Small-Cap Value | 406.90K (1.06%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 20 | Bridgeway Omni Small-Cap Value N | 406.90K (1.06%) | 0.00 Increased by 0.00% | Mar 31, 25 |