| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 22.97M (31.57%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Rubric Capital Management LP | 5.75M (7.90%) | 1.04M Increased by +18.08% | Dec 31, 25 |
| 3 | BlackRock Inc | 3.99M (5.48%) | 195.26K Increased by +4.89% | Sep 30, 25 |
| 4 | Morgan Stanley - Brokerage Accounts | 3.98M (5.48%) | -193.03K Decreased by -4.84% | Sep 30, 25 |
| 5 | Bvf Inc | 3.94M (5.41%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 6 | Redmile Group, LLC | 3.71M (5.09%) | -444.88K Decreased by -12.01% | Sep 30, 25 |
| 7 | Vanguard Group Inc | 2.33M (3.20%) | 174.29K Increased by +7.48% | Dec 31, 25 |
| 8 | Perceptive Advisors LLC | 2.09M (2.87%) | 815.39K Increased by +39.00% | Sep 30, 25 |
| 9 | BNP Paribas Investment Partners SA | 2.04M (2.80%) | -158.22K Decreased by -7.76% | Jun 30, 25 |
| 10 | Credit Suisse First Boston (CSFB) | 1.90M (2.61%) | -407.86K Decreased by -21.51% | Mar 31, 24 |
| 11 | UBS Asset Mgmt Americas Inc | 1.71M (2.35%) | -749.05K Decreased by -43.79% | Sep 30, 25 |
| 12 | Siren, L.L.C. | 1.68M (2.31%) | 1.68M Increased by +100.00% | Dec 31, 25 |
| 13 | Blackstone Inc | 1.62M (2.22%) | -40.50K Decreased by -2.51% | Sep 30, 25 |
| 14 | Deutsche Bank AG | 1.54M (2.12%) | 135.00 Increased by +0.01% | Sep 30, 25 |
| 15 | Farallon Capital Management, L.L.C. | 1.33M (1.83%) | -31.03K Decreased by -2.33% | Dec 31, 24 |
| 16 | Prosight Management, LP | 1.31M (1.80%) | 352.68K Increased by +26.92% | Jun 30, 25 |
| 17 | Dimensional Fund Advisors, Inc. | 1.16M (1.59%) | -31.62K Decreased by -2.73% | Dec 31, 25 |
| 18 | Nextech Invest AG | 1.11M (1.53%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 19 | Nextech Invest, Ltd. | 1.11M (1.53%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 20 | Millennium Management LLC | 1.10M (1.52%) | 988.71K Increased by +89.49% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HBM Healthcare Investments AG Ord | 2.52M (3.47%) | 311.65K Increased by +12.35% | Dec 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 2.24M (3.07%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | CS (Lux) Digital Health Equity SB USD | 2.20M (3.02%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.65M (2.27%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 5 | iShares Russell 2000 ETF | 1.21M (1.66%) | 1.21M Increased by +100.00% | Feb 28, 26 |
| 6 | UBS (Lux) Digital Health Equity SB USD | 1.08M (1.48%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 7 | BNP Paribas US Small Cap Classic R | 1.07M (1.47%) | -21.54K Decreased by -2.01% | May 31, 25 |
| 8 | BNP Paribas US Small Cap ClassicC | 939.85K (1.29%) | 939.85K Increased by +100.00% | Jan 31, 26 |
| 9 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 844.70K (1.16%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 10 | Xtrackers S&P 500 Swap ETF 1C | 768.75K (1.06%) | -5.67K Decreased by -0.74% | Dec 31, 25 |
| 11 | Xtrackers S&P 500 2xLev Dly Swap ETF 1C | 632.16K (0.87%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | iShares Biotechnology ETF | 544.62K (0.75%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 13 | Fidelity® Small Cap Index | 516.34K (0.71%) | 13.80K Increased by +2.67% | Oct 31, 23 |
| 14 | iShares Russell 2000 Value ETF | 497.32K (0.68%) | 0.00 Increased by 0.00% | May 31, 25 |
| 15 | BNP Paribas Health Cr Innovtr Cl Cap | 488.80K (0.67%) | 488.80K Increased by +100.00% | Jan 31, 26 |
| 16 | Fidelity Small Cap Index | 488.52K (0.67%) | -13.03K Decreased by -2.67% | Dec 31, 25 |
| 17 | Nuveen Quant Small Cap Equity R6 | 419.90K (0.58%) | -3.63K Decreased by -0.86% | Dec 31, 25 |
| 18 | iShares Russell 2000 Growth ETF | 416.01K (0.57%) | 416.01K Increased by +100.00% | Feb 28, 26 |
| 19 | Bridgeway Omni Small-Cap Value | 406.90K (0.56%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 20 | Bridgeway Omni Small-Cap Value N | 406.90K (0.56%) | 0.00 Increased by 0.00% | Mar 31, 25 |