| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 22.97M (33.77%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 2 | Rubric Capital Management LP | 7.00M (10.29%) | 1.25M Increased by +17.86% | Mar 31, 26 |
| 3 | BlackRock Inc | 4.55M (6.70%) | -41.66K Decreased by -0.91% | Mar 31, 26 |
| 4 | Bvf Inc | 3.73M (5.49%) | -204.50K Decreased by -5.48% | Mar 31, 26 |
| 5 | Redmile Group, LLC | 3.71M (5.45%) | -444.88K Decreased by -12.01% | Sep 30, 25 |
| 6 | Perceptive Advisors LLC | 3.51M (5.16%) | 248.23K Increased by +7.07% | Mar 31, 26 |
| 7 | Morgan Stanley - Brokerage Accounts | 2.48M (3.65%) | -112.51K Decreased by -4.54% | Mar 31, 26 |
| 8 | Vanguard Group Inc | 2.33M (3.42%) | 174.29K Increased by +7.48% | Dec 31, 25 |
| 9 | BNP Paribas Investment Partners SA | 1.91M (2.81%) | 85.99K Increased by +4.51% | Mar 31, 26 |
| 10 | Credit Suisse First Boston (CSFB) | 1.90M (2.79%) | -407.86K Decreased by -21.51% | Mar 31, 24 |
| 11 | UBS Asset Mgmt Americas Inc | 1.71M (2.51%) | -749.05K Decreased by -43.79% | Sep 30, 25 |
| 12 | Vanguard Capital Management, LLC | 1.71M (2.51%) | 1.71M Increased by +100.00% | Mar 31, 26 |
| 13 | Siren, L.L.C. | 1.68M (2.47%) | 1.68M Increased by +100.00% | Dec 31, 25 |
| 14 | Blackstone Inc | 1.62M (2.38%) | -40.50K Decreased by -2.51% | Sep 30, 25 |
| 15 | Farallon Capital Management, L.L.C. | 1.33M (1.96%) | -31.03K Decreased by -2.33% | Dec 31, 24 |
| 16 | Assenagon Asset Management SA | 1.25M (1.84%) | 524.04K Increased by +41.86% | Jun 30, 26 |
| 17 | Citadel Advisors Llc | 1.15M (1.69%) | 894.67K Increased by +77.80% | Mar 31, 26 |
| 18 | Dimensional Fund Advisors, Inc. | 1.14M (1.67%) | -20.08K Decreased by -1.76% | Mar 31, 26 |
| 19 | Nextech Invest AG | 1.11M (1.64%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 20 | Nextech Invest, Ltd. | 1.11M (1.64%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HBM Healthcare Investments AG Ord | 2.52M (3.71%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 2 | Vanguard US Total Market Shares ETF | 2.24M (3.29%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | CS (Lux) Digital Health Equity SB USD | 2.20M (3.23%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.51M (2.22%) | -142.70K Decreased by -9.46% | Jun 30, 26 |
| 5 | iShares Russell 2000 ETF | 1.22M (1.79%) | 7.23K Increased by +0.59% | Jun 30, 26 |
| 6 | UBS (Lux) Digital Health Equity SB USD | 1.08M (1.59%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 7 | BNP Paribas US Small Cap Classic R | 1.07M (1.57%) | -21.54K Decreased by -2.01% | May 31, 25 |
| 8 | BNP Paribas US Small Cap ClassicC | 992.94K (1.46%) | -5.79K Decreased by -0.58% | May 31, 26 |
| 9 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 844.70K (1.24%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 10 | Xtrackers S&P 500 Swap ETF 1C | 768.75K (1.13%) | -5.67K Decreased by -0.74% | Dec 31, 25 |
| 11 | Xtrackers S&P 500 2xLev Dly Swap ETF 1C | 632.16K (0.93%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | Fidelity® Small Cap Index | 516.34K (0.76%) | 13.80K Increased by +2.67% | Oct 31, 23 |
| 13 | iShares Biotechnology ETF | 505.80K (0.74%) | 5.24K Increased by +1.04% | Jun 30, 26 |
| 14 | iShares Russell 2000 Value ETF | 497.32K (0.73%) | 0.00 Increased by 0.00% | May 31, 25 |
| 15 | Fidelity Small Cap Index | 492.55K (0.72%) | 4.25K Increased by +0.86% | Apr 30, 26 |
| 16 | BNP Paribas Health Cr Innovtr Cl Cap | 473.06K (0.70%) | -214.00 Decreased by -0.05% | May 31, 26 |
| 17 | iShares Russell 2000 Growth ETF | 432.70K (0.64%) | -1.67K Decreased by -0.38% | Jun 30, 26 |
| 18 | Bridgeway Omni Small-Cap Value | 406.90K (0.60%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 19 | Bridgeway Omni Small-Cap Value N | 406.90K (0.60%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 20 | Fidelity Small Cap Growth | 369.10K (0.54%) | 0.00 Increased by 0.00% | Apr 30, 26 |