| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 17.26M (45.15%) | 2.23M Increased by +12.93% | Mar 31, 25 |
| 2 | Redmile Group, LLC | 4.79M (12.53%) | -51.52K Decreased by -1.08% | Mar 31, 25 |
| 3 | Rubric Capital Management LP | 4.34M (11.35%) | 421.11K Increased by +9.71% | Mar 31, 25 |
| 4 | Bvf Inc | 4.31M (11.27%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | BlackRock Inc | 4.09M (10.70%) | -95.53K Decreased by -2.34% | Mar 31, 25 |
| 6 | Morgan Stanley - Brokerage Accounts | 4.07M (10.66%) | -127.97K Decreased by -3.14% | Mar 31, 25 |
| 7 | UBS Asset Mgmt Americas Inc | 3.88M (10.15%) | 2.51M Increased by +64.82% | Mar 31, 25 |
| 8 | BNP Paribas Investment Partners SA | 2.20M (5.75%) | 60.23K Increased by +2.74% | Mar 31, 25 |
| 9 | Credit Suisse First Boston (CSFB) | 1.90M (4.96%) | -407.86K Decreased by -21.51% | Mar 31, 24 |
| 10 | Perceptive Advisors LLC | 1.86M (4.88%) | -265.35K Decreased by -14.23% | Mar 31, 25 |
| 11 | Vanguard Group Inc | 1.77M (4.62%) | -726.25K Decreased by -41.10% | Mar 31, 25 |
| 12 | Deutsche Bank AG | 1.55M (4.06%) | 5.84K Increased by +0.38% | Mar 31, 25 |
| 13 | Blackstone Inc | 1.38M (3.62%) | 812.87K Increased by +58.79% | Mar 31, 25 |
| 14 | Farallon Capital Management, L.L.C. | 1.33M (3.48%) | -31.03K Decreased by -2.33% | Dec 31, 24 |
| 15 | Nextech Invest AG | 1.11M (2.91%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 16 | Nextech Invest, Ltd. | 1.11M (2.91%) | 1.11M Increased by +100.00% | Mar 31, 25 |
| 17 | TANG CAPITAL MANAGEMENT LLC | 1.10M (2.88%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 18 | State Street Corp | 1.09M (2.84%) | 172.00 Increased by +0.02% | Mar 31, 25 |
| 19 | Dimensional Fund Advisors, Inc. | 1.08M (2.82%) | 106.72K Increased by +9.89% | Mar 31, 25 |
| 20 | Prosight Management, LP | 957.23K (2.50%) | 137.23K Increased by +14.34% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard US Total Market Shares ETF | 2.24M (5.85%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 2 | CS (Lux) Digital Health Equity SB USD | 2.20M (5.76%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 3 | HBM Healthcare Investments AG Ord | 2.00M (5.22%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 4 | iShares Russell 2000 ETF | 1.36M (3.56%) | 0.00 Increased by 0.00% | May 31, 25 |
| 5 | Vanguard Total Stock Mkt Idx Inv | 1.22M (3.19%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 6 | BNP Paribas US Small Cap Classic R | 1.09M (2.85%) | -159.56K Decreased by -14.63% | Apr 30, 25 |
| 7 | UBS (Lux) Digital Health Equity SB USD | 1.08M (2.83%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 8 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 1.05M (2.74%) | -32.90K Decreased by -3.14% | Apr 30, 25 |
| 9 | BNP Paribas Health Cr Innovtr Cl Cap | 796.03K (2.08%) | 39.00 Increased by +0.00% | Apr 30, 25 |
| 10 | Xtrackers S&P 500 Swap ETF 1C | 774.42K (2.03%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 11 | Xtrackers S&P 500 2xLev Dly Swap ETF 1C | 632.16K (1.65%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 12 | Fidelity Small Cap Index | 544.40K (1.42%) | 5.46K Increased by +1.00% | Mar 31, 25 |
| 13 | Fidelity® Small Cap Index | 516.34K (1.35%) | 13.80K Increased by +2.67% | Oct 31, 23 |
| 14 | iShares Russell 2000 Value ETF | 497.32K (1.30%) | 0.00 Increased by 0.00% | May 31, 25 |
| 15 | Bridgeway Omni Small-Cap Value | 406.90K (1.06%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | Bridgeway Omni Small-Cap Value N | 406.90K (1.06%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 17 | iShares Biotechnology ETF | 393.66K (1.03%) | 0.00 Increased by 0.00% | May 31, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 337.00K (0.88%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx SL Cl I | 337.00K (0.88%) | 0.00 Increased by 0.00% | May 31, 25 |
| 20 | Jupiter Merian Glb Eq AbsRet I USD Acc | 336.93K (0.88%) | -34.97K Decreased by -10.38% | Dec 31, 24 |