| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 22.97M (30.82%) | 5.71M Increased by +24.86% | Jun 30, 25 |
| 2 | Rubric Capital Management LP | 4.71M (6.32%) | 372.11K Increased by +7.90% | Jun 30, 25 |
| 3 | Bvf Inc | 4.31M (5.78%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Morgan Stanley - Brokerage Accounts | 4.18M (5.60%) | 104.15K Increased by +2.49% | Jun 30, 25 |
| 5 | Redmile Group, LLC | 4.15M (5.57%) | -638.32K Decreased by -15.38% | Jun 30, 25 |
| 6 | BlackRock Inc | 3.79M (5.09%) | -295.15K Decreased by -7.78% | Jun 30, 25 |
| 7 | Vanguard Group Inc | 2.46M (3.31%) | 697.65K Increased by +28.31% | Jun 30, 25 |
| 8 | UBS Asset Mgmt Americas Inc | 2.46M (3.30%) | -1.42M Decreased by -57.75% | Jun 30, 25 |
| 9 | BNP Paribas Investment Partners SA | 2.04M (2.74%) | -158.22K Decreased by -7.76% | Jun 30, 25 |
| 10 | Credit Suisse First Boston (CSFB) | 1.90M (2.54%) | -407.86K Decreased by -21.51% | Mar 31, 24 |
| 11 | Blackstone Inc | 1.66M (2.22%) | 274.20K Increased by +16.55% | Jun 30, 25 |
| 12 | Deutsche Bank AG | 1.54M (2.07%) | -7.85K Decreased by -0.51% | Jun 30, 25 |
| 13 | Farallon Capital Management, L.L.C. | 1.33M (1.78%) | -31.03K Decreased by -2.33% | Dec 31, 24 |
| 14 | Prosight Management, LP | 1.31M (1.76%) | 352.68K Increased by +26.92% | Jun 30, 25 |
| 15 | Perceptive Advisors LLC | 1.28M (1.71%) | -589.40K Decreased by -46.22% | Jun 30, 25 |
| 16 | Dimensional Fund Advisors, Inc. | 1.19M (1.60%) | 112.97K Increased by +9.47% | Jun 30, 25 |
| 17 | Vestal Point Capital LP | 1.15M (1.54%) | 650.00K Increased by +56.52% | Jun 30, 25 |
| 18 | Nextech Invest AG | 1.11M (1.49%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 19 | Nextech Invest, Ltd. | 1.11M (1.49%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 20 | TANG CAPITAL MANAGEMENT LLC | 1.10M (1.48%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard US Total Market Shares ETF | 2.24M (3.00%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 2 | CS (Lux) Digital Health Equity SB USD | 2.20M (2.95%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 3 | HBM Healthcare Investments AG Ord | 2.00M (2.68%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.85M (2.48%) | -40.86K Decreased by -2.21% | Jul 31, 25 |
| 5 | iShares Russell 2000 ETF | 1.22M (1.63%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 6 | BNP Paribas US Small Cap ClassicC | 1.09M (1.46%) | 2.82K Increased by +0.26% | Jul 31, 25 |
| 7 | UBS (Lux) Digital Health Equity SB USD | 1.08M (1.45%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 8 | BNP Paribas US Small Cap Classic R | 1.07M (1.43%) | -21.54K Decreased by -2.01% | May 31, 25 |
| 9 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 844.70K (1.13%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 10 | BNP Paribas Health Cr Innovtr Cl Cap | 795.67K (1.07%) | -789.00 Decreased by -0.10% | Jul 31, 25 |
| 11 | Xtrackers S&P 500 Swap ETF 1C | 774.42K (1.04%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 12 | Xtrackers S&P 500 2xLev Dly Swap ETF 1C | 632.16K (0.85%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 13 | Fidelity® Small Cap Index | 516.34K (0.69%) | 13.80K Increased by +2.67% | Oct 31, 23 |
| 14 | iShares Russell 2000 Value ETF | 497.32K (0.67%) | 0.00 Increased by 0.00% | May 31, 25 |
| 15 | Fidelity Small Cap Index | 491.61K (0.66%) | -59.71K Decreased by -12.15% | Jun 30, 25 |
| 16 | Nuveen Quant Small Cap Equity R6 | 471.87K (0.63%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 17 | iShares Russell 2000 Growth ETF | 435.07K (0.58%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 18 | Bridgeway Omni Small-Cap Value | 406.90K (0.55%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 19 | Bridgeway Omni Small-Cap Value N | 406.90K (0.55%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 20 | iShares Biotechnology ETF | 405.45K (0.54%) | 0.00 Increased by 0.00% | Aug 31, 25 |