| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Paradigm Biocapital Advisors LP | 4.24M (15.21%) | 150.00K Increased by +3.54% | Dec 31, 24 |
| 2 | BlackRock Inc | 3.00M (10.77%) | -26.76K Decreased by -0.89% | Dec 31, 24 |
| 3 | Sofinnova Ventures | 2.19M (7.88%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 4 | Vanguard Group Inc | 2.00M (7.18%) | -35.34K Decreased by -1.77% | Dec 31, 24 |
| 5 | Polar Capital Holdings PLC | 1.83M (6.58%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 6 | Caligan Partners LP | 1.77M (6.35%) | 572.73K Increased by +32.39% | Dec 31, 24 |
| 7 | State Street Corp | 1.31M (4.72%) | 104.63K Increased by +7.96% | Dec 31, 24 |
| 8 | Logos Global Management LP | 1.00M (3.59%) | 200.00K Increased by +20.00% | Dec 31, 24 |
| 9 | Geode Capital Management, LLC | 822.31K (2.95%) | 8.82K Increased by +1.07% | Dec 31, 24 |
| 10 | Pictet Asset Manangement SA | 756.30K (2.72%) | 68.32K Increased by +9.03% | Dec 31, 24 |
| 11 | State Street Corporation | 751.07K (2.70%) | -10.46K Decreased by -1.39% | Mar 31, 24 |
| 12 | BOOTHBAY FUND MANAGEMENT, LLC | 693.69K (2.49%) | 136.26K Increased by +19.64% | Dec 31, 24 |
| 13 | D. E. Shaw & Co LP | 615.13K (2.21%) | -172.41K Decreased by -28.03% | Dec 31, 24 |
| 14 | Acadian Asset Management LLC | 602.31K (2.16%) | -200.07K Decreased by -33.22% | Mar 31, 24 |
| 15 | Jacobs Levy Equity Management, Inc. | 530.44K (1.90%) | -34.09K Decreased by -6.43% | Sep 30, 23 |
| 16 | Dimensional Fund Advisors, Inc. | 463.24K (1.66%) | -14.43K Decreased by -3.11% | Dec 31, 24 |
| 17 | Cormorant Asset Management, LLC | 425.00K (1.53%) | -1.02M Decreased by -241.18% | Dec 31, 24 |
| 18 | Northern Trust Corp | 359.22K (1.29%) | 21.94K Increased by +6.11% | Dec 31, 24 |
| 19 | Point72 Asset Management, L.P. | 358.94K (1.29%) | -1.17M Decreased by -325.44% | Jun 30, 24 |
| 20 | Soleus Capital Management, L.P. | 349.98K (1.26%) | -50.00K Decreased by -14.29% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HBM Healthcare Investments AG Ord | 3.30M (11.84%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 2 | Polar Capital Biotech S Inc | 1.50M (5.39%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 1.04M (3.73%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 4 | iShares Russell 2000 ETF | 970.46K (3.49%) | -8.41K Decreased by -0.87% | Mar 31, 25 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 500.90K (1.80%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 6 | SPDR® S&P Biotech ETF | 438.23K (1.57%) | -2.67K Decreased by -0.61% | Feb 28, 25 |
| 7 | Pictet Biotech | 390.64K (1.40%) | 390.64K Increased by +100.00% | Mar 31, 24 |
| 8 | Pictet-Biotech P USD | 390.47K (1.40%) | -720.00 Decreased by -0.18% | Dec 31, 24 |
| 9 | Fidelity Small Cap Index | 367.83K (1.32%) | -6.89K Decreased by -1.87% | Jan 31, 25 |
| 10 | Fidelity® Small Cap Index | 356.43K (1.28%) | 9.18K Increased by +2.57% | Oct 31, 23 |
| 11 | iShares Russell 2000 Growth ETF | 325.16K (1.17%) | -1.55K Decreased by -0.48% | Mar 31, 25 |
| 12 | Pictet-Global Megatrend Sel I USD | 311.19K (1.12%) | 749.00 Increased by +0.24% | Dec 31, 24 |
| 13 | Victory Science & Technology | 299.43K (1.08%) | 29.54K Increased by +9.86% | Sep 30, 23 |
| 14 | State St Russell Sm/Mid Cp® Indx NL Cl C | 248.89K (0.89%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 15 | iShares Biotechnology ETF | 222.39K (0.80%) | -2.48K Decreased by -1.12% | Mar 31, 25 |
| 16 | Fidelity Extended Market Index | 183.20K (0.66%) | -1.17K Decreased by -0.64% | Feb 28, 25 |
| 17 | iShares Russell 2000 Value ETF | 181.87K (0.65%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 18 | Vanguard Russell 2000 ETF | 171.66K (0.62%) | 3.94K Increased by +2.29% | Feb 28, 25 |
| 19 | Schwab US Small-Cap ETF™ | 155.26K (0.56%) | 550.00 Increased by +0.35% | Mar 29, 25 |
| 20 | Fidelity® Extended Market Index | 153.06K (0.55%) | 0.00 Increased by 0.00% | Nov 30, 23 |