| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Paradigm Biocapital Advisors LP | 4.24M (22.42%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | BlackRock Inc | 2.75M (14.55%) | -153.95K Decreased by -5.60% | Jun 30, 25 |
| 3 | Caligan Partners LP | 2.34M (12.40%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Sofinnova Ventures | 2.19M (11.62%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 5 | Vanguard Group Inc | 1.94M (10.29%) | -3.22K Decreased by -0.17% | Jun 30, 25 |
| 6 | Polar Capital Holdings PLC | 1.79M (9.47%) | -41.20K Decreased by -2.30% | Jun 30, 25 |
| 7 | Logos Global Management LP | 1.00M (5.29%) | 200.00K Increased by +20.00% | Dec 31, 24 |
| 8 | Geode Capital Management, LLC | 848.46K (4.49%) | -1.04K Decreased by -0.12% | Jun 30, 25 |
| 9 | State Street Corp | 780.14K (4.13%) | -8.88K Decreased by -1.14% | Jun 30, 25 |
| 10 | State Street Corporation | 751.07K (3.98%) | -10.46K Decreased by -1.39% | Mar 31, 24 |
| 11 | BOOTHBAY FUND MANAGEMENT, LLC | 693.69K (3.67%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 12 | Acadian Asset Management LLC | 602.31K (3.19%) | -200.07K Decreased by -33.22% | Mar 31, 24 |
| 13 | D. E. Shaw & Co LP | 516.86K (2.74%) | -32.81K Decreased by -6.35% | Jun 30, 25 |
| 14 | Millennium Management LLC | 466.62K (2.47%) | 431.17K Increased by +92.40% | Mar 31, 25 |
| 15 | Pictet Asset Manangement SA | 441.93K (2.34%) | -314.36K Decreased by -71.13% | Mar 31, 25 |
| 16 | Cormorant Asset Management, LLC | 425.00K (2.25%) | -1.02M Decreased by -241.18% | Dec 31, 24 |
| 17 | Dimensional Fund Advisors, Inc. | 412.25K (2.18%) | -6.31K Decreased by -1.53% | Jun 30, 25 |
| 18 | Point72 Asset Management, L.P. | 358.94K (1.90%) | -1.17M Decreased by -325.44% | Jun 30, 24 |
| 19 | Nantahala Capital Management, LLC | 351.88K (1.86%) | 351.88K Increased by +100.00% | Jun 30, 25 |
| 20 | Soleus Capital Management, L.P. | 349.98K (1.85%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HBM Healthcare Investments AG Ord | 3.30M (17.46%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | Polar Capital Biotech S Inc | 1.78M (9.44%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 1.04M (5.51%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.02M (5.39%) | -22.45K Decreased by -2.21% | Jul 31, 25 |
| 5 | iShares Russell 2000 ETF | 897.24K (4.75%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 6 | SPDR® S&P Biotech ETF | 438.23K (2.32%) | -2.67K Decreased by -0.61% | Feb 28, 25 |
| 7 | Pictet Biotech | 390.64K (2.07%) | 390.64K Increased by +100.00% | Mar 31, 24 |
| 8 | Pictet-Biotech P USD | 385.84K (2.04%) | 3.99K Increased by +1.03% | Mar 31, 25 |
| 9 | Fidelity Small Cap Index | 372.35K (1.97%) | -10.42K Decreased by -2.80% | Jun 30, 25 |
| 10 | Fidelity® Small Cap Index | 356.43K (1.89%) | 9.18K Increased by +2.57% | Oct 31, 23 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 355.66K (1.88%) | -145.24K Decreased by -40.84% | Jul 31, 25 |
| 12 | iShares Russell 2000 Growth ETF | 311.23K (1.65%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 13 | Pictet-Global Megatrend Sel I USD | 311.19K (1.65%) | 749.00 Increased by +0.24% | Dec 31, 24 |
| 14 | Victory Science & Technology | 299.43K (1.59%) | 29.54K Increased by +9.86% | Sep 30, 23 |
| 15 | State St Russell Sm/Mid Cp® Indx NL Cl C | 238.99K (1.27%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx SL Cl I | 238.99K (1.27%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 17 | iShares Biotechnology ETF | 202.86K (1.07%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 18 | Fidelity Extended Market Index | 182.61K (0.97%) | -1.50K Decreased by -0.82% | Jul 31, 25 |
| 19 | iShares Russell 2000 Value ETF | 181.87K (0.96%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 20 | Vanguard Russell 2000 ETF | 175.90K (0.93%) | -11.55K Decreased by -6.57% | Jul 31, 25 |