| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Paradigm Biocapital Advisors LP | 4.24M (16.78%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | BlackRock Inc | 2.90M (11.49%) | -96.45K Decreased by -3.32% | Mar 31, 25 |
| 3 | Caligan Partners LP | 2.34M (9.28%) | 574.63K Increased by +24.53% | Mar 31, 25 |
| 4 | Sofinnova Ventures | 2.19M (8.69%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | Vanguard Group Inc | 1.95M (7.71%) | -53.51K Decreased by -2.75% | Mar 31, 25 |
| 6 | Polar Capital Holdings PLC | 1.83M (7.25%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 7 | Logos Global Management LP | 1.00M (3.96%) | 200.00K Increased by +20.00% | Dec 31, 24 |
| 8 | Geode Capital Management, LLC | 849.50K (3.36%) | 27.19K Increased by +3.20% | Mar 31, 25 |
| 9 | State Street Corp | 789.02K (3.12%) | -525.39K Decreased by -66.59% | Mar 31, 25 |
| 10 | State Street Corporation | 751.07K (2.97%) | -10.46K Decreased by -1.39% | Mar 31, 24 |
| 11 | BOOTHBAY FUND MANAGEMENT, LLC | 693.69K (2.75%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | D. E. Shaw & Co LP | 615.13K (2.44%) | -172.41K Decreased by -28.03% | Dec 31, 24 |
| 13 | Acadian Asset Management LLC | 602.31K (2.39%) | -200.07K Decreased by -33.22% | Mar 31, 24 |
| 14 | Morgan Stanley - Brokerage Accounts | 500.16K (1.98%) | 179.35K Increased by +35.86% | Mar 31, 25 |
| 15 | Pictet Asset Manangement SA | 441.93K (1.75%) | -314.36K Decreased by -71.13% | Mar 31, 25 |
| 16 | Cormorant Asset Management, LLC | 425.00K (1.68%) | -1.02M Decreased by -241.18% | Dec 31, 24 |
| 17 | Dimensional Fund Advisors, Inc. | 418.55K (1.66%) | -44.68K Decreased by -10.68% | Mar 31, 25 |
| 18 | Northern Trust Corp | 359.22K (1.42%) | 21.94K Increased by +6.11% | Dec 31, 24 |
| 19 | Point72 Asset Management, L.P. | 358.94K (1.42%) | -1.17M Decreased by -325.44% | Jun 30, 24 |
| 20 | Soleus Capital Management, L.P. | 349.98K (1.39%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HBM Healthcare Investments AG Ord | 3.30M (13.06%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | Polar Capital Biotech S Inc | 1.50M (5.94%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 1.04M (4.12%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 4 | Vanguard US Total Market Shares ETF | 1.04M (4.12%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | iShares Russell 2000 ETF | 905.13K (3.58%) | 153.00 Increased by +0.02% | Apr 30, 25 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 500.90K (1.98%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 7 | SPDR® S&P Biotech ETF | 438.23K (1.74%) | -2.67K Decreased by -0.61% | Feb 28, 25 |
| 8 | Pictet-Biotech P USD | 396.79K (1.57%) | 6.32K Increased by +1.59% | Jan 31, 25 |
| 9 | Pictet Biotech | 390.64K (1.55%) | 390.64K Increased by +100.00% | Mar 31, 24 |
| 10 | Fidelity Small Cap Index | 373.83K (1.48%) | 6.01K Increased by +1.61% | Feb 28, 25 |
| 11 | Fidelity® Small Cap Index | 356.43K (1.41%) | 9.18K Increased by +2.57% | Oct 31, 23 |
| 12 | iShares Russell 2000 Growth ETF | 326.32K (1.29%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 13 | Pictet-Global Megatrend Sel I USD | 311.19K (1.23%) | 749.00 Increased by +0.24% | Dec 31, 24 |
| 14 | Victory Science & Technology | 299.43K (1.19%) | 29.54K Increased by +9.86% | Sep 30, 23 |
| 15 | State St Russell Sm/Mid Cp® Indx NL Cl C | 238.99K (0.95%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx SL Cl I | 238.99K (0.95%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 17 | iShares Biotechnology ETF | 216.74K (0.86%) | 496.00 Increased by +0.23% | Apr 30, 25 |
| 18 | Fidelity Extended Market Index | 187.19K (0.74%) | 3.99K Increased by +2.13% | Mar 31, 25 |
| 19 | Vanguard Russell 2000 ETF | 185.83K (0.74%) | 10.21K Increased by +5.49% | Apr 30, 25 |
| 20 | iShares Russell 2000 Value ETF | 181.87K (0.72%) | 0.00 Increased by 0.00% | Apr 30, 24 |