| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Paradigm Biocapital Advisors LP | 4.24M (22.79%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | BlackRock Inc | 2.90M (15.61%) | -96.45K Decreased by -3.32% | Mar 31, 25 |
| 3 | Caligan Partners LP | 2.34M (12.60%) | 574.63K Increased by +24.53% | Mar 31, 25 |
| 4 | Sofinnova Ventures | 2.19M (11.80%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | Vanguard Group Inc | 1.95M (10.47%) | -53.51K Decreased by -2.75% | Mar 31, 25 |
| 6 | Polar Capital Holdings PLC | 1.83M (9.85%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 7 | Logos Global Management LP | 1.00M (5.38%) | 200.00K Increased by +20.00% | Dec 31, 24 |
| 8 | Geode Capital Management, LLC | 849.50K (4.57%) | 27.19K Increased by +3.20% | Mar 31, 25 |
| 9 | State Street Corp | 789.02K (4.24%) | -525.39K Decreased by -66.59% | Mar 31, 25 |
| 10 | State Street Corporation | 751.07K (4.04%) | -10.46K Decreased by -1.39% | Mar 31, 24 |
| 11 | BOOTHBAY FUND MANAGEMENT, LLC | 693.69K (3.73%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | Acadian Asset Management LLC | 602.31K (3.24%) | -200.07K Decreased by -33.22% | Mar 31, 24 |
| 13 | D. E. Shaw & Co LP | 549.67K (2.96%) | -65.47K Decreased by -11.91% | Mar 31, 25 |
| 14 | Morgan Stanley - Brokerage Accounts | 500.16K (2.69%) | 179.35K Increased by +35.86% | Mar 31, 25 |
| 15 | Millennium Management LLC | 466.62K (2.51%) | 431.17K Increased by +92.40% | Mar 31, 25 |
| 16 | Pictet Asset Manangement SA | 441.93K (2.38%) | -314.36K Decreased by -71.13% | Mar 31, 25 |
| 17 | Cormorant Asset Management, LLC | 425.00K (2.29%) | -1.02M Decreased by -241.18% | Dec 31, 24 |
| 18 | Dimensional Fund Advisors, Inc. | 418.55K (2.25%) | -44.68K Decreased by -10.68% | Mar 31, 25 |
| 19 | Point72 Asset Management, L.P. | 358.94K (1.93%) | -1.17M Decreased by -325.44% | Jun 30, 24 |
| 20 | Soleus Capital Management, L.P. | 349.98K (1.88%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HBM Healthcare Investments AG Ord | 3.30M (17.74%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | Polar Capital Biotech S Inc | 1.78M (9.59%) | 283.80K Increased by +15.91% | Jun 30, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 1.04M (5.59%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Vanguard US Total Market Shares ETF | 1.04M (5.59%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | iShares Russell 2000 ETF | 844.39K (4.54%) | -16.07K Decreased by -1.90% | Jul 31, 25 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 500.90K (2.69%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 7 | SPDR® S&P Biotech ETF | 438.23K (2.36%) | -2.67K Decreased by -0.61% | Feb 28, 25 |
| 8 | Pictet Biotech | 390.64K (2.10%) | 390.64K Increased by +100.00% | Mar 31, 24 |
| 9 | Pictet-Biotech P USD | 385.84K (2.08%) | 3.99K Increased by +1.03% | Mar 31, 25 |
| 10 | Fidelity Small Cap Index | 382.77K (2.06%) | -5.05K Decreased by -1.32% | May 31, 25 |
| 11 | Fidelity® Small Cap Index | 356.43K (1.92%) | 9.18K Increased by +2.57% | Oct 31, 23 |
| 12 | iShares Russell 2000 Growth ETF | 311.23K (1.67%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 13 | Pictet-Global Megatrend Sel I USD | 311.19K (1.67%) | 749.00 Increased by +0.24% | Dec 31, 24 |
| 14 | Victory Science & Technology | 299.43K (1.61%) | 29.54K Increased by +9.86% | Sep 30, 23 |
| 15 | State St Russell Sm/Mid Cp® Indx NL Cl C | 238.99K (1.29%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx SL Cl I | 238.99K (1.29%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 17 | iShares Biotechnology ETF | 215.60K (1.16%) | 1.84K Increased by +0.85% | Jul 31, 25 |
| 18 | Vanguard Russell 2000 ETF | 187.45K (1.01%) | -82.00 Decreased by -0.04% | Jun 30, 25 |
| 19 | Fidelity Extended Market Index | 184.11K (0.99%) | -481.00 Decreased by -0.26% | Jun 30, 25 |
| 20 | iShares Russell 2000 Value ETF | 181.87K (0.98%) | 0.00 Increased by 0.00% | Apr 30, 24 |