| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 6.58M (8.76%) | 1.15M Increased by +17.49% | Dec 31, 25 |
| 2 | Vanguard Group Inc | 4.15M (5.53%) | 673.70K Increased by +16.22% | Dec 31, 25 |
| 3 | Logos Global Management LP | 4.05M (5.40%) | 3.05M Increased by +75.31% | Sep 30, 25 |
| 4 | Polar Capital Holdings PLC | 3.93M (5.23%) | 2.87M Increased by +73.03% | Dec 31, 25 |
| 5 | Point72 Asset Management, L.P. | 3.88M (5.17%) | 3.88M Increased by +100.00% | Sep 30, 25 |
| 6 | BlackRock Inc | 3.72M (4.95%) | 958.27K Increased by +25.78% | Sep 30, 25 |
| 7 | Armistice Capital, LLC | 3.54M (4.71%) | 1.44M Increased by +40.72% | Dec 31, 25 |
| 8 | Bvf Inc | 3.40M (4.54%) | 1.30M Increased by +38.30% | Jun 30, 25 |
| 9 | Balyasny Asset Management LLC | 3.20M (4.26%) | -951.04K Decreased by -29.76% | Dec 31, 25 |
| 10 | Foresite Capital Management VI LLC | 3.14M (4.18%) | 520.00K Increased by +16.59% | Dec 31, 25 |
| 11 | Nantahala Capital Management, LLC | 2.95M (3.94%) | 656.19K Increased by +22.21% | Jun 30, 25 |
| 12 | Orbimed Advisors, LLC | 2.86M (3.81%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 13 | Stonepine Capital Management Llc | 2.73M (3.64%) | 62.05K Increased by +2.27% | Dec 31, 25 |
| 14 | Viking Global Investors LP | 2.46M (3.27%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 15 | Citadel Advisors Llc | 2.35M (3.14%) | 2.17M Increased by +92.15% | Dec 31, 25 |
| 16 | State Street Corp | 2.23M (2.97%) | -22.78K Decreased by -1.02% | Sep 30, 25 |
| 17 | AIGH Capital Management, LLC | 2.00M (2.67%) | -334.57K Decreased by -16.70% | Jun 30, 25 |
| 18 | Farallon Capital Management, L.L.C. | 2.00M (2.66%) | 2.00M Increased by +100.00% | Dec 31, 25 |
| 19 | SymBiosis Capital Partners, LLC | 2.00M (2.66%) | 2.00M Increased by +100.00% | Dec 31, 25 |
| 20 | Alyeska Investment Group, L.P. | 1.86M (2.48%) | 1.16M Increased by +62.36% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Polar Capital Biotech S Inc | 3.50M (4.66%) | 3.50M Increased by +100.00% | Jan 31, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.42M (3.23%) | 61.40K Increased by +2.53% | Jan 31, 26 |
| 3 | State Street® SPDR® S&P® Biotech ETF | 2.15M (2.87%) | 11.94K Increased by +0.55% | Feb 28, 26 |
| 4 | RTW Biotech Opportunities Ord | 1.92M (2.56%) | 1.92M Increased by +100.00% | Jun 30, 25 |
| 5 | iShares Russell 2000 ETF | 1.31M (1.74%) | 1.31M Increased by +100.00% | Feb 28, 26 |
| 6 | SPDR® S&P Biotech ETF | 1.28M (1.70%) | 2.85K Increased by +0.22% | Aug 31, 25 |
| 7 | Vanguard US Total Market Shares ETF | 1.22M (1.62%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 8 | Vanguard Institutional Extnd Mkt Idx Tr | 687.71K (0.92%) | 3.54K Increased by +0.51% | Jan 31, 26 |
| 9 | Franklin Biotechnology Discv A(acc)USD | 590.76K (0.79%) | 152.67K Increased by +25.84% | Dec 31, 25 |
| 10 | Kennedy Micro Cap | 547.19K (0.73%) | 359.19K Increased by +65.64% | Sep 30, 24 |
| 11 | Fidelity Small Cap Index | 523.72K (0.70%) | 64.03K Increased by +12.23% | Dec 31, 25 |
| 12 | MEDICAL BioHealth EUR Acc | 520.91K (0.69%) | 520.91K Increased by +100.00% | Jan 31, 26 |
| 13 | Franklin Biotechnology Discovery A | 401.74K (0.54%) | 66.70K Increased by +16.60% | Jan 31, 26 |
| 14 | Fidelity Enhanced Small Cap ETF | 400.65K (0.53%) | 0.00 Increased by 0.00% | Feb 27, 26 |
| 15 | Fidelity Extended Market Index | 331.82K (0.44%) | -1.38K Decreased by -0.41% | Jan 31, 26 |
| 16 | Nuveen Equity Index R6 | 328.95K (0.44%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 295.92K (0.39%) | 9.40K Increased by +3.18% | Feb 28, 26 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 291.12K (0.39%) | 1.22K Increased by +0.42% | Apr 30, 25 |
| 19 | Vanguard Russell 2000 ETF | 254.66K (0.34%) | -7.38K Decreased by -2.90% | Jan 31, 26 |
| 20 | iShares Russell 2000 Growth ETF | 247.67K (0.33%) | 247.67K Increased by +100.00% | Feb 28, 26 |