| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 14.38M (14.08%) | 2.14M Increased by +14.84% | Dec 31, 25 |
| 2 | Vanguard Group Inc | 5.61M (5.49%) | 1.28M Increased by +22.81% | Dec 31, 25 |
| 3 | BlackRock Inc | 5.43M (5.31%) | -92.51K Decreased by -1.70% | Sep 30, 25 |
| 4 | Deep Track Capital, LP | 5.38M (5.27%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 5 | State Street Corporation | 4.49M (4.39%) | 1.78M Increased by +39.66% | Mar 31, 24 |
| 6 | Bellevue Group AG | 4.36M (4.27%) | 4.36M Increased by +100.00% | Dec 31, 25 |
| 7 | Fairmount Funds Management LLC | 3.91M (3.83%) | 454.55K Increased by +11.61% | Dec 31, 25 |
| 8 | VR Adviser, LLC | 3.88M (3.80%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | COMMODORE CAPITAL LP | 3.20M (3.13%) | -1.68M Decreased by -52.34% | Sep 30, 25 |
| 10 | TANG CAPITAL MANAGEMENT LLC | 2.84M (2.78%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 11 | Paradigm Biocapital Advisors LP | 2.74M (2.68%) | 646.50K Increased by +23.58% | Jun 30, 25 |
| 12 | State Street Corp | 2.55M (2.50%) | 740.00 Increased by +0.03% | Sep 30, 25 |
| 13 | T. Rowe Price Associates, Inc. | 2.42M (2.37%) | -477.16K Decreased by -19.73% | Sep 30, 25 |
| 14 | Novo A/S | 2.38M (2.33%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 15 | Maverick Capital Ltd | 2.21M (2.17%) | -44.31K Decreased by -2.00% | Sep 30, 25 |
| 16 | RA Capital Management, LLC | 2.01M (1.97%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 17 | Baker Bros Advisors LP | 1.97M (1.93%) | 227.27K Increased by +11.53% | Dec 31, 25 |
| 18 | Wellington Management Company LLP | 1.97M (1.93%) | 848.88K Increased by +43.06% | Dec 31, 25 |
| 19 | EcoR1 Capital, LLC | 1.96M (1.92%) | 1.96M Increased by +100.00% | Sep 30, 24 |
| 20 | Eversept Partners, LP | 1.92M (1.88%) | 21.77K Increased by +1.13% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 2.80M (2.74%) | 9.86K Increased by +0.35% | Jan 31, 26 |
| 2 | Fidelity Select Health Care | 2.80M (2.74%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 3 | Vanguard US Total Market Shares ETF | 2.24M (2.20%) | 324.50K Increased by +14.47% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 1.94M (1.90%) | 1.38M Increased by +71.04% | Feb 28, 26 |
| 5 | Fidelity Advisor Biotechnology I | 1.78M (1.74%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 6 | State Street® SPDR® S&P® Biotech ETF | 1.66M (1.63%) | -58.56K Decreased by -3.52% | Feb 27, 26 |
| 7 | Fidelity Advisor Health Care I | 1.50M (1.47%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 8 | Fidelity Small Cap Growth | 1.27M (1.24%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | Fidelity Advisor® Biotechnology I | 1.21M (1.18%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 10 | Fidelity Select Biotechnology | 1.08M (1.05%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 11 | US Small-Cap Growth II Equity Comp | 1.06M (1.04%) | 179.58K Increased by +16.97% | Dec 31, 25 |
| 12 | T. Rowe Price New Horizons | 1.06M (1.03%) | -1.08K Decreased by -0.10% | Jan 31, 26 |
| 13 | Strategic Advisers Fidelity US TtlStk | 955.12K (0.93%) | -25.20K Decreased by -2.64% | Jan 31, 26 |
| 14 | SPDR® S&P Biotech ETF | 931.02K (0.91%) | 2.08K Increased by +0.22% | Aug 31, 25 |
| 15 | Vanguard Institutional Extnd Mkt Idx Tr | 919.91K (0.90%) | 1.87K Increased by +0.20% | Jan 31, 26 |
| 16 | MEDICAL BioHealth EUR Acc | 912.19K (0.89%) | 912.19K Increased by +100.00% | Jan 31, 26 |
| 17 | Fidelity Stock Selector Small Cap | 892.35K (0.87%) | 25.30K Increased by +2.84% | Dec 31, 25 |
| 18 | AB Small Cap Growth A | 869.99K (0.85%) | -12.97K Decreased by -1.49% | Jul 31, 25 |
| 19 | FIAM Small Cap Core CIT Cl B | 857.10K (0.84%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 20 | Loomis Sayles Small Cap Growth Instl | 803.66K (0.79%) | -16.12K Decreased by -2.01% | Jan 31, 26 |