| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | 5AM Venture Management, LLC | 6.36M (17.74%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | RA Capital Management, LLC | 5.40M (15.07%) | 3.42M Increased by +63.32% | Dec 31, 25 |
| 3 | FCPM III SERVICES BV | 3.62M (10.09%) | 3.24M Increased by +89.51% | Dec 31, 25 |
| 4 | Frazier Life Sciences Management, L.P. | 2.54M (7.09%) | 2.54M Increased by +100.00% | Dec 31, 25 |
| 5 | FMR Inc | 2.53M (7.05%) | 2.29M Increased by +90.64% | Dec 31, 25 |
| 6 | Hudson Bay Capital Management LP | 2.47M (6.88%) | 2.47M Increased by +100.00% | Sep 30, 24 |
| 7 | VR Adviser, LLC | 1.94M (5.42%) | 1.44M Increased by +74.28% | Dec 31, 25 |
| 8 | Paradigm Biocapital Advisors LP | 1.75M (4.88%) | 1.75M Increased by +100.00% | Dec 31, 25 |
| 9 | Great Point Partners LLC | 1.37M (3.82%) | 1.37M Increased by +100.00% | Dec 31, 25 |
| 10 | COWEN AND COMPANY, LLC | 1.22M (3.40%) | 1.22M Increased by +100.00% | Sep 30, 24 |
| 11 | Woodline Partners LP | 1.11M (3.10%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 12 | Artal Group S A | 1.00M (2.79%) | -1.35M Decreased by -134.74% | Mar 31, 24 |
| 13 | NEXTBio Capital Management LP | 999.97K (2.79%) | 999.97K Increased by +100.00% | Dec 31, 25 |
| 14 | Caligan Partners LP | 925.07K (2.58%) | 925.07K Increased by +100.00% | Dec 31, 25 |
| 15 | Vanguard Group Inc | 770.25K (2.15%) | 665.06K Increased by +86.34% | Dec 31, 25 |
| 16 | State Street Corporation | 657.71K (1.83%) | 49.70K Increased by +7.56% | Mar 31, 24 |
| 17 | Baker Bros Advisors LP | 633.85K (1.77%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 18 | HRT FINANCIAL LLC | 474.57K (1.32%) | 474.57K Increased by +100.00% | Jun 30, 25 |
| 19 | Renaissance Technologies Corp | 468.11K (1.31%) | -233.32K Decreased by -49.84% | Jun 30, 25 |
| 20 | Citadel Advisors Llc | 433.89K (1.21%) | 428.21K Increased by +98.69% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl O | 2.12M (5.91%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 2 | Fidelity Growth Compy Commingled Pl S | 1.96M (5.48%) | -207.80K Decreased by -10.58% | Apr 30, 25 |
| 3 | Fidelity Select Biotechnology | 1.54M (4.28%) | -836.00K Decreased by -54.42% | Feb 28, 26 |
| 4 | Fidelity® Growth Company | 1.43M (3.99%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 5 | Vanguard US Total Market Shares ETF | 1.39M (3.86%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | Fidelity Growth Company Fund | 1.27M (3.55%) | -140.15K Decreased by -11.00% | Apr 30, 25 |
| 7 | Fidelity® Select Biotechnology | 1.11M (3.11%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 8 | State Street® SPDR® S&P® Biotech ETF | 932.40K (2.60%) | 14.28K Increased by +1.53% | Mar 31, 26 |
| 9 | iShares Russell 2000 ETF | 776.40K (2.17%) | -6.20K Decreased by -0.80% | Apr 30, 24 |
| 10 | Fidelity VIP Growth Initial | 618.39K (1.72%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 11 | VIP Growth Initial | 618.39K (1.72%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 12 | Fidelity Capital Appreciation | 610.40K (1.70%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 13 | Fidelity® Capital Appreciation | 610.40K (1.70%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 14 | Fidelity® Growth Company K6 | 603.64K (1.68%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 15 | Vanguard Total Stock Mkt Idx Inv | 475.88K (1.33%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 16 | Fidelity Advisor® Equity Growth I | 474.94K (1.32%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 17 | Fidelity Advisor Equity Growth I | 474.17K (1.32%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 18 | Fidelity Growth Company K6 | 438.61K (1.22%) | -43.30K Decreased by -9.87% | Apr 30, 25 |
| 19 | Fidelity Small Cap Index | 384.43K (1.07%) | 13.14K Increased by +3.42% | Jun 30, 24 |
| 20 | iShares Russell 2000 Value ETF | 383.06K (1.07%) | 0.00 Increased by 0.00% | Apr 30, 24 |