| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Novo A/S | 2.31M (1.64%) | -40.00K Decreased by -1.74% | Dec 31, 25 |
| 2 | Frazier Life Sciences Management, L.P. | 2.29M (1.63%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | General American Investors Co Inc | 354.36K (0.25%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 4 | General American Investors Company Inc | 354.36K (0.25%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 5 | Wells Fargo & Co | 153.99K (0.11%) | -91.19K Decreased by -59.22% | Sep 30, 25 |
| 6 | Morgan Stanley - Brokerage Accounts | 32.99K (0.02%) | 24.95K Increased by +75.64% | Sep 30, 25 |
| 7 | Ironwood Investment Management LLC | 25.14K (0.02%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | Citadel Advisors Llc | 23.49K (0.02%) | 7.08K Increased by +30.15% | Dec 31, 25 |
| 9 | JPMorgan Chase & Co | 20.36K (0.01%) | 20.36K Increased by +100.00% | Sep 30, 25 |
| 10 | XTX Topco Ltd | 10.63K (0.01%) | 10.63K Increased by +100.00% | Dec 31, 25 |
| 11 | China Universal Asset Mgmt Co.Ltd | 5.00K (0.00%) | 5.00K Increased by +100.00% | Dec 31, 25 |
| 12 | Rhumbline Advisers | 1.76K (0.00%) | 1.54K Increased by +87.63% | Dec 31, 25 |
| 13 | Advisor Group Holdings, Inc. | 1.55K (0.00%) | 1.00K Increased by +64.31% | Dec 31, 25 |
| 14 | GAMMA Investing LLC | 1.43K (0.00%) | -431.00 Decreased by -30.22% | Mar 31, 26 |
| 15 | UBS Group AG | 472.00 (0.00%) | 471.00 Increased by +99.79% | Sep 30, 25 |
| 16 | Barclays PLC | 196.00 (0.00%) | 196.00 Increased by +100.00% | Sep 30, 25 |
| 17 | AlphaMark Advisors, LLC | 150.00 (0.00%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 18 | EverSource Wealth Advisors, LLC | 98.00 (0.00%) | -2.00 Decreased by -2.04% | Dec 31, 25 |
| 19 | Hartland & Co | 48.00 (0.00%) | 48.00 Increased by +100.00% | Dec 31, 25 |
| 20 | Royal Bank of Canada | 18.00 (0.00%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | General American Investors | 354.36K (0.25%) | 354.36K Increased by +100.00% | Dec 31, 25 |
| 2 | AlphaCentric Life Sciences & Hlthcare I | 88.25K (0.06%) | 26.25K Increased by +29.74% | Jun 30, 24 |
| 3 | AlphaCentric LifeSci Healthcare I | 88.25K (0.06%) | 26.25K Increased by +29.74% | Jun 30, 24 |
| 4 | China Universal Gbl YLBJ QDII CNH | 5.00K (0.00%) | 5.00K Increased by +100.00% | Dec 31, 25 |
| 5 | Fidelity Nasdaq Composite Index | 2.88K (0.00%) | 0.00 Increased by 0.00% | Feb 28, 26 |