| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | venBio Select Advisor LLC | 20.00M (14.51%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | RTW INVESTMENTS, LLC | 18.79M (13.63%) | 10.12M Increased by +53.84% | Mar 31, 25 |
| 3 | Morgan Stanley - Brokerage Accounts | 16.85M (12.22%) | -793.99K Decreased by -4.71% | Mar 31, 25 |
| 4 | FMR Inc | 15.63M (11.34%) | -733.71K Decreased by -4.69% | Mar 31, 25 |
| 5 | BlackRock Inc | 13.59M (9.86%) | 57.71K Increased by +0.42% | Mar 31, 25 |
| 6 | RA Capital Management, LLC | 10.87M (7.89%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 7 | Octagon Capital Advisors LP | 10.70M (7.76%) | 250.00K Increased by +2.34% | Mar 31, 25 |
| 8 | Vanguard Group Inc | 8.77M (6.36%) | -135.84K Decreased by -1.55% | Mar 31, 25 |
| 9 | Siren, L.L.C. | 6.51M (4.73%) | -87.74K Decreased by -1.35% | Mar 31, 25 |
| 10 | Adage Capital Partners Gp LLC | 5.00M (3.63%) | 5.00M Increased by +100.00% | Dec 31, 24 |
| 11 | Point72 Asset Management, L.P. | 4.57M (3.32%) | 4.57M Increased by +100.00% | Mar 31, 25 |
| 12 | Artal Group S A | 4.35M (3.16%) | 666.67K Increased by +15.31% | Jun 30, 24 |
| 13 | Baker Bros Advisors LP | 4.00M (2.91%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 14 | Tybourne Capital Management (HK) Ltd | 3.70M (2.68%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 15 | Geode Capital Management, LLC | 3.66M (2.66%) | 92.38K Increased by +2.52% | Mar 31, 25 |
| 16 | Kynam Capital Management, LP | 3.28M (2.38%) | 3.28M Increased by +100.00% | Sep 30, 23 |
| 17 | State Street Corp | 3.23M (2.35%) | -3.24M Decreased by -100.23% | Mar 31, 25 |
| 18 | VR Adviser, LLC | 3.23M (2.34%) | -5.77M Decreased by -179.05% | Dec 31, 24 |
| 19 | Millennium Management LLC | 3.14M (2.27%) | -245.22K Decreased by -7.82% | Mar 31, 24 |
| 20 | Polar Capital Holdings PLC | 3.00M (2.18%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity® Select Biotechnology | 10.99M (7.98%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 2 | Fidelity Growth Compy Commingled Pl O | 6.48M (4.70%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 3 | Fidelity Growth Compy Commingled Pl S | 5.35M (3.88%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 4.85M (3.52%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 5 | Vanguard US Total Market Shares ETF | 4.46M (3.23%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | iShares Russell 2000 ETF | 4.27M (3.10%) | 722.00 Increased by +0.02% | Apr 30, 25 |
| 7 | Fidelity Growth Company Fund | 4.22M (3.06%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 8 | Fidelity® Growth Company | 3.67M (2.66%) | 138.70K Increased by +3.78% | Nov 30, 23 |
| 9 | Fidelity Select Biotechnology | 3.41M (2.47%) | -401.67K Decreased by -11.78% | Mar 31, 25 |
| 10 | Polar Capital Biotech S Inc | 3.00M (2.18%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 11 | SPDR® S&P Biotech ETF | 2.68M (1.94%) | -16.32K Decreased by -0.61% | Feb 28, 25 |
| 12 | Xtrackers MSCI World Swap ETF 1C | 2.47M (1.79%) | 0.00 Increased by 0.00% | Oct 31, 24 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 2.24M (1.62%) | 1.03K Increased by +0.05% | Apr 30, 25 |
| 14 | Fidelity Small Cap Index | 1.74M (1.26%) | 23.06K Increased by +1.32% | Feb 28, 25 |
| 15 | Fidelity Growth Company K6 | 1.58M (1.15%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | iShares Russell 2000 Growth ETF | 1.58M (1.14%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 17 | Fidelity® Growth Company K6 | 1.55M (1.12%) | -168.15K Decreased by -10.88% | Nov 30, 23 |
| 18 | Eagle Small Cap Core Inst'l | 1.26M (0.92%) | -298.60K Decreased by -23.64% | Jun 30, 24 |
| 19 | MEDICAL BioHealth EUR Acc | 1.02M (0.74%) | 0.00 Increased by 0.00% | Jul 31, 24 |
| 20 | Fidelity Series Growth Company | 1.01M (0.73%) | 20.80K Increased by +2.06% | Mar 31, 25 |