| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 13.30M (19.11%) | 11.81M Increased by +88.79% | Mar 31, 26 |
| 2 | Farallon Capital Management, L.L.C. | 13.06M (18.77%) | 2.30M Increased by +17.64% | Dec 31, 25 |
| 3 | Boxer Capital Management, LLC | 10.88M (15.63%) | 1.10M Increased by +10.16% | Dec 31, 25 |
| 4 | EcoR1 Capital, LLC | 10.63M (15.27%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 5 | Adage Capital Partners Gp LLC | 10.61M (15.24%) | 8.10M Increased by +76.33% | Dec 31, 25 |
| 6 | TCG Crossover Management, LLC | 10.53M (15.13%) | -2.23M Decreased by -21.19% | Mar 31, 26 |
| 7 | Woodline Partners LP | 10.07M (14.47%) | 4.04M Increased by +40.13% | Dec 31, 25 |
| 8 | BlackRock Inc | 8.54M (12.27%) | 2.89M Increased by +33.88% | Dec 31, 25 |
| 9 | Boxer Capital LLC | 8.20M (11.78%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 10 | Siren, L.L.C. | 8.17M (11.73%) | 2.28M Increased by +27.95% | Dec 31, 25 |
| 11 | Nextech Invest, Ltd. | 7.27M (10.44%) | 1.73M Increased by +23.84% | Dec 31, 25 |
| 12 | Vanguard Group Inc | 6.75M (9.70%) | 1.70M Increased by +25.17% | Dec 31, 25 |
| 13 | TRV GP IV, LLC | 6.37M (9.16%) | -1.50M Decreased by -23.53% | Mar 31, 26 |
| 14 | State Street Corp | 6.22M (8.93%) | 2.85M Increased by +45.88% | Dec 31, 25 |
| 15 | Nextech Invest AG | 5.53M (7.95%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 16 | Balyasny Asset Management LLC | 5.28M (7.58%) | 1.81M Increased by +34.22% | Dec 31, 25 |
| 17 | Southpoint Capital Advisors LP | 5.00M (7.18%) | -276.70K Decreased by -5.53% | Sep 30, 24 |
| 18 | The Goldman Sachs Group Inc | 4.94M (7.10%) | 3.43M Increased by +69.46% | Dec 31, 25 |
| 19 | Paradigm Biocapital Advisors LP | 4.01M (5.76%) | 4.01M Increased by +100.00% | Mar 31, 26 |
| 20 | Bellevue Group AG | 3.93M (5.64%) | 3.93M Increased by +100.00% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 3.93M (5.65%) | 18.51K Increased by +0.47% | Mar 31, 26 |
| 2 | iShares Russell 2000 ETF | 2.62M (3.76%) | 22.04K Increased by +0.84% | Apr 30, 26 |
| 3 | Fidelity Select Biotechnology | 2.53M (3.63%) | 1.94M Increased by +76.80% | Mar 31, 26 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 2.20M (3.17%) | -15.66K Decreased by -0.71% | Apr 30, 26 |
| 5 | Fidelity Growth Compy Commingled Pl S | 2.17M (3.12%) | 2.17M Increased by +100.00% | Mar 31, 26 |
| 6 | Fidelity Growth Company Fund | 1.74M (2.50%) | 1.74M Increased by +100.00% | Mar 31, 26 |
| 7 | Fidelity Growth Compy Commingled Pl O | 1.69M (2.43%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 8 | T. Rowe Price Small-Cap Value | 1.54M (2.21%) | -117.06K Decreased by -7.59% | Jul 31, 25 |
| 9 | Fidelity® Small Cap Growth | 1.26M (1.81%) | -1.53K Decreased by -0.12% | Oct 31, 23 |
| 10 | FIAM Small Cap Core CIT Cl B | 1.26M (1.81%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 11 | FIAM Small Cap Core Composite | 1.26M (1.81%) | 1.26M Increased by +100.00% | Dec 31, 25 |
| 12 | Fidelity Small Cap Growth | 1.25M (1.80%) | 0.00 Increased by 0.00% | Oct 31, 24 |
| 13 | T. Rowe Price Small-Cap Stock | 1.19M (1.70%) | 199.50K Increased by +16.82% | Sep 30, 24 |
| 14 | T. Rowe Price US Small-Cap Core Equity | 1.19M (1.70%) | 277.63K Increased by +23.40% | Sep 30, 24 |
| 15 | SPDR® S&P Biotech ETF | 1.12M (1.62%) | 16.00K Increased by +1.42% | Nov 30, 24 |
| 16 | Vanguard Institutional Extnd Mkt Idx Tr | 1.10M (1.58%) | 24.16K Increased by +2.20% | Mar 31, 26 |
| 17 | Fidelity Small Cap Index | 1.04M (1.50%) | 10.43K Increased by +1.00% | Feb 28, 26 |
| 18 | Fidelity® Growth Company | 1.02M (1.46%) | 52.20K Increased by +5.12% | Nov 30, 23 |
| 19 | T. Rowe Price U.S. SC Value Eq Tr-D | 971.86K (1.40%) | 4.71K Increased by +0.48% | Jun 30, 25 |
| 20 | T. Rowe Price U.S. SC Value Eq Tr-Z | 967.15K (1.39%) | 1.56K Increased by +0.16% | Mar 31, 25 |