| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 21.85M (16.17%) | 548.04K Increased by +2.51% | Dec 31, 25 |
| 2 | Vanguard Group Inc | 15.84M (11.72%) | 319.70K Increased by +2.02% | Dec 31, 25 |
| 3 | State Street Corp | 8.48M (6.28%) | 379.38K Increased by +4.47% | Dec 31, 25 |
| 4 | State Street Corporation | 7.80M (5.77%) | -456.99K Decreased by -5.86% | Mar 31, 24 |
| 5 | Darwin Global Management, Ltd. | 4.05M (3.00%) | 4.05M Increased by +100.00% | Dec 31, 23 |
| 6 | ClearBridge Advisors, LLC | 3.45M (2.55%) | -1.20M Decreased by -34.70% | Dec 31, 25 |
| 7 | Geode Capital Management, LLC | 3.40M (2.52%) | -40.05K Decreased by -1.18% | Dec 31, 25 |
| 8 | Soleus Capital Management, L.P. | 3.14M (2.32%) | -705.42K Decreased by -22.47% | Dec 31, 25 |
| 9 | Woodline Partners LP | 2.57M (1.90%) | 1.15M Increased by +44.66% | Sep 30, 24 |
| 10 | Opaleye Management Inc | 2.26M (1.67%) | -20.00K Decreased by -0.88% | Dec 31, 24 |
| 11 | Paradigm Biocapital Advisors LP | 2.17M (1.61%) | -1.45M Decreased by -66.67% | Dec 31, 23 |
| 12 | Congress Asset Management Company, LLP | 2.17M (1.60%) | 245.67K Increased by +11.33% | Mar 31, 26 |
| 13 | Marshall Wace Asset Management Ltd | 2.05M (1.52%) | 2.05M Increased by +100.00% | Jun 30, 24 |
| 14 | The Goldman Sachs Group Inc | 2.05M (1.52%) | 531.76K Increased by +25.93% | Dec 31, 25 |
| 15 | Sofinnova Ventures | 1.86M (1.38%) | -123.69K Decreased by -6.65% | Jun 30, 24 |
| 16 | Nuveen Asset Management, LLC | 1.80M (1.33%) | -232.34K Decreased by -12.91% | Dec 31, 24 |
| 17 | Pictet Asset Manangement SA | 1.75M (1.29%) | 286.32K Increased by +16.39% | Mar 31, 26 |
| 18 | Deep Track Capital, LP | 1.73M (1.28%) | -1.15M Decreased by -66.38% | Sep 30, 24 |
| 19 | Bank of America Corp | 1.70M (1.26%) | -384.52K Decreased by -22.65% | Sep 30, 24 |
| 20 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1.61M (1.19%) | 958.95K Increased by +59.47% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | iShares Core S&P Small-Cap ETF | 8.28M (6.13%) | 11.17K Increased by +0.13% | Apr 29, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 4.82M (3.57%) | 27.02K Increased by +0.56% | Mar 31, 26 |
| 3 | Vanguard US Total Market Shares ETF | 4.36M (3.23%) | 3.80K Increased by +0.09% | Sep 30, 24 |
| 4 | Vanguard Small Cap Index | 3.48M (2.58%) | 55.80K Increased by +1.60% | Mar 31, 26 |
| 5 | iShares Russell 2000 ETF | 3.39M (2.51%) | -6.50K Decreased by -0.19% | Apr 29, 26 |
| 6 | State Street® SPDR® S&P® Biotech ETF | 3.37M (2.49%) | -33.30K Decreased by -0.99% | Apr 30, 26 |
| 7 | Vanguard Health Care Inv | 3.07M (2.27%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 8 | SPDR® S&P Biotech ETF | 2.30M (1.70%) | 5.12K Increased by +0.22% | Aug 31, 25 |
| 9 | Vanguard Small Cap Growth Index Inv | 1.95M (1.44%) | 48.99K Increased by +2.51% | Mar 31, 26 |
| 10 | Pictet Biotech | 1.79M (1.33%) | 1.79M Increased by +100.00% | Mar 31, 24 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 1.52M (1.13%) | 39.73K Increased by +2.61% | Mar 31, 26 |
| 12 | Fidelity Small Cap Index | 1.42M (1.05%) | 15.41K Increased by +1.08% | Feb 28, 26 |
| 13 | Fidelity® Small Cap Index | 1.32M (0.98%) | 35.93K Increased by +2.72% | Oct 31, 23 |
| 14 | ClearBridge SMID Cap Growth | 1.30M (0.96%) | 1.30M Increased by +99.99% | Mar 31, 26 |
| 15 | Vanguard Explorer Inv | 1.30M (0.96%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 16 | Congress Small Cap Growth Institutional | 1.25M (0.93%) | 35.00K Increased by +2.79% | Mar 31, 26 |
| 17 | State Street SPDR Port S&P 600 Sm CpETF | 1.24M (0.92%) | 432.00 Increased by +0.03% | Apr 30, 26 |
| 18 | SPDR® Portfolio S&P 600™ Sm Cap ETF | 1.20M (0.89%) | 14.39K Increased by +1.20% | Aug 29, 25 |
| 19 | iShares S&P Small-Cap 600 Growth ETF | 1.20M (0.88%) | 0.00 Increased by 0.00% | Apr 29, 26 |
| 20 | iShares Russell 2000 Growth ETF | 1.19M (0.88%) | 3.90K Increased by +0.33% | Apr 29, 26 |