| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Essex Woodlands Health Ventures | 4.11M (20.02%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 2 | Nantahala Capital Management, LLC | 3.68M (17.92%) | 1.76M Increased by +47.95% | Dec 31, 24 |
| 3 | SILVERARC CAPITAL MANAGEMENT, LLC | 3.07M (14.93%) | 1.94M Increased by +63.31% | Dec 31, 24 |
| 4 | First Light Asset Management, LLC | 2.75M (13.41%) | 199.39K Increased by +7.24% | Mar 31, 24 |
| 5 | AIGH Capital Management, LLC | 2.66M (12.97%) | 193.41K Increased by +7.26% | Dec 31, 24 |
| 6 | Stonepine Capital Management Llc | 2.35M (11.46%) | 1.24M Increased by +52.83% | Dec 31, 24 |
| 7 | Orbimed Advisors, LLC | 2.16M (10.52%) | -296.36K Decreased by -13.71% | Sep 30, 24 |
| 8 | Vanguard Group Inc | 1.88M (9.13%) | 972.08K Increased by +51.83% | Dec 31, 24 |
| 9 | Dafna Capital Management LLC | 1.44M (7.02%) | 1.44M Increased by +100.00% | Dec 31, 24 |
| 10 | Paradigm Capital Management, Inc. | 1.26M (6.12%) | 740.93K Increased by +58.98% | Jun 30, 24 |
| 11 | Royce & Associates, LP | 1.00M (4.87%) | 1.00M Increased by +100.00% | Dec 31, 24 |
| 12 | Pentwater Capital Management LP | 1.00M (4.87%) | 500.00K Increased by +50.00% | Dec 31, 24 |
| 13 | Perkins Capital Management Inc | 907.87K (4.42%) | 682.66K Increased by +75.19% | Dec 31, 24 |
| 14 | UBS Group AG | 767.83K (3.74%) | 767.83K Increased by +100.00% | Dec 31, 24 |
| 15 | Citigroup Inc | 750.00K (3.65%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 16 | Opaleye Management Inc | 750.00K (3.65%) | -830.00K Decreased by -110.67% | Sep 30, 23 |
| 17 | Velan Capital Investment Management LP | 747.41K (3.64%) | 1.32K Increased by +0.18% | Sep 30, 24 |
| 18 | Federated Hermes Inc | 712.30K (3.47%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 19 | Sio Capital Management, LLC | 630.00K (3.07%) | 630.00K Increased by +100.00% | Dec 31, 24 |
| 20 | Sectoral Asset Management Inc | 525.00K (2.56%) | 346.63K Increased by +66.02% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.18M (5.74%) | 74.60K Increased by +6.33% | Feb 28, 25 |
| 2 | Vanguard Institutional Extnd Mkt Idx Tr | 738.48K (3.60%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 3 | FTGF RY US SmCp Opp A USD Dis(A) | 553.14K (2.69%) | 31.95K Increased by +5.78% | Feb 28, 25 |
| 4 | Royce Small-Cap Opportunity Invmt | 532.97K (2.60%) | 532.97K Increased by +100.00% | Dec 31, 24 |
| 5 | Federated Hermes Kaufmann Growth | 500.00K (2.43%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 6 | Federated Hermes Kaufmann R | 500.00K (2.43%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 7 | iShares Russell 2000 ETF | 359.80K (1.75%) | -2.87K Decreased by -0.80% | Apr 30, 24 |
| 8 | Kennedy Micro Cap | 293.76K (1.43%) | 1.41K Increased by +0.48% | Jun 30, 24 |
| 9 | Federated Hermes Kaufmann Small Cap A | 200.00K (0.97%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 10 | Federated Hermes Kaufmann Small Cap Grow | 200.00K (0.97%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 11 | Paradigm Micro-Cap | 200.00K (0.97%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | Fidelity Small Cap Index | 163.54K (0.80%) | 3.91K Increased by +2.39% | Jun 30, 24 |
| 13 | Fidelity Extended Market Index | 161.16K (0.78%) | -1.03K Decreased by -0.64% | Feb 28, 25 |
| 14 | Fidelity® Small Cap Index | 155.60K (0.76%) | 3.54K Increased by +2.28% | Oct 31, 23 |
| 15 | Jacob Discovery Fd Instl | 154.78K (0.75%) | 15.00K Increased by +9.69% | Dec 31, 24 |
| 16 | iShares Russell 2000 Growth ETF | 132.15K (0.64%) | -316.00 Decreased by -0.24% | Apr 30, 24 |
| 17 | Next Century Growth Micro Cap Growth | 126.43K (0.62%) | -82.13K Decreased by -64.96% | Sep 30, 23 |
| 18 | Calamos Timpani Small Cap Growth I | 110.59K (0.54%) | -26.56K Decreased by -24.02% | Mar 31, 24 |
| 19 | Timpani Small Cap Growth Equity | 110.59K (0.54%) | -3.02K Decreased by -2.73% | Mar 31, 24 |
| 20 | Protea Sectoral Hlthcare Opps P USD Acc | 95.00K (0.46%) | 0.00 Increased by 0.00% | Oct 31, 23 |