| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 24.47M (18.82%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Bain Capital Life Sciences Investors, LLC | 17.60M (13.54%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | VR Adviser, LLC | 13.74M (10.57%) | 1.06M Increased by +7.71% | Dec 31, 25 |
| 4 | Deerfield Management Co | 13.57M (10.44%) | 5.61M Increased by +41.31% | Dec 31, 25 |
| 5 | TCG Crossover Management, LLC | 12.36M (9.51%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 6 | Vestal Point Capital LP | 11.02M (8.47%) | 15.00K Increased by +0.14% | Jun 30, 25 |
| 7 | Vanguard Group Inc | 10.04M (7.72%) | 1.73M Increased by +17.21% | Dec 31, 25 |
| 8 | Frazier Life Sciences Management, L.P. | 9.86M (7.59%) | -1.60M Decreased by -16.22% | Dec 31, 25 |
| 9 | BlackRock Inc | 8.45M (6.50%) | -1.33M Decreased by -15.71% | Sep 30, 25 |
| 10 | Polar Capital Holdings PLC | 8.31M (6.39%) | 8.31M Increased by +100.00% | Dec 31, 25 |
| 11 | Nantahala Capital Management, LLC | 7.34M (5.65%) | -1.43M Decreased by -19.48% | Dec 31, 25 |
| 12 | Farallon Capital Management, L.L.C. | 6.83M (5.26%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 13 | Jennison Associates LLC | 6.73M (5.18%) | 1.00M Increased by +14.87% | Sep 30, 24 |
| 14 | RTW INVESTMENTS, LLC | 5.95M (4.58%) | 5.95M Increased by +100.00% | Dec 31, 25 |
| 15 | Marshall Wace Asset Management Ltd | 4.56M (3.51%) | 4.56M Increased by +100.00% | Dec 31, 25 |
| 16 | Woodline Partners LP | 4.24M (3.26%) | 4.01M Increased by +94.41% | Dec 31, 25 |
| 17 | ADAR1 Capital Management LLC | 3.60M (2.77%) | 2.24M Increased by +62.22% | Jun 30, 25 |
| 18 | Emerald Advisers, LLC | 3.50M (2.69%) | -33.83K Decreased by -0.97% | Dec 31, 25 |
| 19 | Geode Capital Management, LLC | 3.42M (2.63%) | 622.11K Increased by +18.20% | Dec 31, 25 |
| 20 | Rosalind Advisors, Inc. | 3.40M (2.62%) | -596.28K Decreased by -17.52% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Polar Capital Healthcare Opports Inc | 8.19M (6.30%) | 327.04K Increased by +3.99% | Feb 28, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 6.07M (4.67%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 4.93M (3.80%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Jennison Health Sciences Equity | 3.78M (2.91%) | 463.66K Increased by +12.28% | Sep 30, 24 |
| 5 | PGIM Jennison Health Sciences Z | 3.78M (2.91%) | 0.00 Increased by 0.00% | Oct 31, 24 |
| 6 | State Street® SPDR® S&P® Biotech ETF | 3.55M (2.73%) | 53.45K Increased by +1.50% | Mar 31, 26 |
| 7 | iShares Russell 2000 ETF | 3.55M (2.73%) | -28.95K Decreased by -0.82% | Mar 31, 26 |
| 8 | SPDR® S&P Biotech ETF | 1.56M (1.20%) | -9.50K Decreased by -0.61% | Feb 28, 25 |
| 9 | Vanguard Institutional Extnd Mkt Idx Tr | 1.50M (1.15%) | 18.28K Increased by +1.22% | Feb 28, 26 |
| 10 | Fidelity Small Cap Index | 1.37M (1.06%) | -16.87K Decreased by -1.23% | Jan 31, 26 |
| 11 | Polar Capital Glb Healthcare Ord | 1.35M (1.04%) | 120.57K Increased by +8.93% | Feb 28, 26 |
| 12 | iShares Russell 2000 Growth ETF | 1.20M (0.92%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 13 | UTM IM GBP AXA Framlington Biotech | 1.01M (0.77%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 14 | Fidelity Advisor Biotechnology I | 986.50K (0.76%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 15 | Principal SmallCap Growth I Instl | 931.64K (0.72%) | -1.65K Decreased by -0.18% | Feb 28, 26 |
| 16 | Fidelity® Small Cap Index | 874.11K (0.67%) | 26.44K Increased by +3.03% | Oct 31, 23 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 850.75K (0.65%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 18 | Emerald Growth A | 798.88K (0.61%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 19 | iShares Russell 2000 Value ETF | 790.67K (0.61%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 20 | iShares Biotechnology ETF | 777.17K (0.60%) | 1.61K Increased by +0.21% | Mar 31, 26 |