| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 17.24M (18.78%) | 1.86M Increased by +10.80% | Mar 31, 26 |
| 2 | Artal Group S A | 11.26M (12.26%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 3 | Siren, L.L.C. | 10.83M (11.79%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 4 | Redmile Group, LLC | 9.07M (9.87%) | 3.85M Increased by +42.42% | Mar 31, 26 |
| 5 | BlackRock Inc | 7.47M (8.14%) | 252.26K Increased by +3.38% | Mar 31, 26 |
| 6 | Samsara BioCapital, LLC | 6.90M (7.51%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 7 | Wellington Management Company LLP | 6.72M (7.32%) | 958.23K Increased by +14.26% | Mar 31, 26 |
| 8 | T. Rowe Price Associates, Inc. | 6.21M (6.76%) | -195.82K Decreased by -3.16% | Mar 31, 26 |
| 9 | Vanguard Group Inc | 5.20M (5.66%) | 280.54K Increased by +5.40% | Dec 31, 25 |
| 10 | Orbis Allan Gray Ltd | 4.18M (4.55%) | 751.05K Increased by +17.97% | Mar 31, 26 |
| 11 | State Street Corporation | 4.17M (4.54%) | 2.01M Increased by +48.21% | Mar 31, 24 |
| 12 | State Street Corp | 4.03M (4.39%) | -3.12K Decreased by -0.08% | Mar 31, 26 |
| 13 | Vanguard Capital Management, LLC | 3.89M (4.24%) | 3.89M Increased by +100.00% | Mar 31, 26 |
| 14 | Bellevue Group AG | 3.58M (3.90%) | -472.02K Decreased by -13.17% | Mar 31, 26 |
| 15 | Jennison Associates LLC | 3.34M (3.64%) | 545.30K Increased by +16.32% | Mar 31, 26 |
| 16 | Paradigm Biocapital Advisors LP | 3.06M (3.34%) | 1.05M Increased by +34.37% | Dec 31, 25 |
| 17 | HHG PLC | 2.24M (2.44%) | 462.67K Increased by +20.68% | Mar 31, 26 |
| 18 | Eventide Asset Management, LLC | 2.20M (2.39%) | -233.95K Decreased by -10.65% | Mar 31, 26 |
| 19 | Geode Capital Management, LLC | 2.15M (2.34%) | 115.01K Increased by +5.35% | Mar 31, 26 |
| 20 | NORGES BANK | 2.08M (2.26%) | 904.24K Increased by +43.48% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 5.92M (6.45%) | 140.03K Increased by +2.36% | Apr 30, 26 |
| 2 | Fidelity Growth Company Fund | 4.40M (4.79%) | 253.00K Increased by +5.75% | Apr 30, 26 |
| 3 | Vanguard Health Care Inv | 3.68M (4.01%) | 928.77K Increased by +25.25% | Mar 31, 26 |
| 4 | Fidelity Growth Compy Commingled Pl O | 3.59M (3.91%) | 36.80K Increased by +1.02% | Aug 31, 24 |
| 5 | BB Biotech AG Ord | 3.24M (3.53%) | 305.67K Increased by +9.44% | Sep 30, 25 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 2.80M (3.05%) | 8.03K Increased by +0.29% | Apr 30, 26 |
| 7 | Fidelity® Select Biotechnology | 2.49M (2.71%) | 428.93K Increased by +17.25% | Nov 30, 23 |
| 8 | Vanguard US Total Market Shares ETF | 2.29M (2.50%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 9 | Fidelity® Growth Company | 2.19M (2.38%) | 66.00K Increased by +3.02% | Nov 30, 23 |
| 10 | State Street® SPDR® S&P® Biotech ETF | 2.17M (2.37%) | -13.37K Decreased by -0.62% | May 31, 26 |
| 11 | iShares Russell 2000 ETF | 2.09M (2.27%) | 19.29K Increased by +0.92% | May 29, 26 |
| 12 | T. Rowe Price New Horizons | 1.89M (2.06%) | 26.75K Increased by +1.42% | Apr 30, 26 |
| 13 | Polar Capital Biotech S Inc | 1.87M (2.04%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 14 | US Small-Cap Growth II Equity Comp | 1.86M (2.03%) | 10.48K Increased by +0.56% | Mar 31, 26 |
| 15 | Fidelity Advisor® Biotechnology I | 1.67M (1.82%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 16 | Fidelity Select Biotechnology | 1.65M (1.80%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 17 | Eventide Gilead N | 1.46M (1.59%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 18 | Fidelity Growth Company K6 | 1.26M (1.37%) | 24.77K Increased by +1.97% | Apr 30, 26 |
| 19 | T. Rowe Price Integrated US SmCapGrEq | 1.25M (1.36%) | 624.53K Increased by +50.00% | Dec 31, 24 |
| 20 | SPDR® S&P Biotech ETF | 1.22M (1.33%) | 2.71K Increased by +0.22% | Aug 31, 25 |