| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 13.64M (19.54%) | 3.44M Increased by +25.22% | Dec 31, 24 |
| 2 | Artal Group S A | 11.26M (16.13%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 3 | T. Rowe Price Associates, Inc. | 9.28M (13.30%) | 629.32K Increased by +6.78% | Dec 31, 24 |
| 4 | Siren, L.L.C. | 9.25M (13.25%) | -2.01M Decreased by -21.72% | Dec 31, 24 |
| 5 | BlackRock Inc | 7.17M (10.28%) | 1.02M Increased by +14.18% | Dec 31, 24 |
| 6 | Samsara BioCapital, LLC | 5.61M (8.04%) | -1.18M Decreased by -20.95% | Dec 31, 24 |
| 7 | Vanguard Group Inc | 4.74M (6.80%) | 708.82K Increased by +14.94% | Dec 31, 24 |
| 8 | Redmile Group, LLC | 4.55M (6.52%) | -688.96K Decreased by -15.14% | Dec 31, 24 |
| 9 | State Street Corporation | 4.17M (5.98%) | 2.01M Increased by +48.21% | Mar 31, 24 |
| 10 | Marshall Wace Asset Management Ltd | 2.95M (4.22%) | 2.73M Increased by +92.77% | Dec 31, 24 |
| 11 | Polar Capital Holdings PLC | 2.71M (3.88%) | -232.30K Decreased by -8.58% | Dec 31, 24 |
| 12 | Eventide Asset Management, LLC | 2.66M (3.81%) | 250.03K Increased by +9.40% | Dec 31, 24 |
| 13 | State Street Corp | 2.64M (3.78%) | -134.22K Decreased by -5.09% | Dec 31, 24 |
| 14 | Bellevue Group AG | 2.51M (3.60%) | 349.49K Increased by +13.92% | Dec 31, 24 |
| 15 | NORGES BANK | 1.99M (2.85%) | 1.99M Increased by +100.00% | Dec 31, 24 |
| 16 | Fairmount Funds Management LLC | 1.96M (2.81%) | 1.96M Increased by +100.00% | Dec 31, 24 |
| 17 | Hood River Capital Management LLC | 1.90M (2.72%) | -451.08K Decreased by -23.76% | Dec 31, 24 |
| 18 | Geode Capital Management, LLC | 1.77M (2.54%) | 227.30K Increased by +12.84% | Dec 31, 24 |
| 19 | Wellington Management Company LLP | 1.73M (2.47%) | 1.53M Increased by +88.42% | Dec 31, 24 |
| 20 | Goldman Sachs Group Inc | 1.72M (2.47%) | 321.38K Increased by +18.68% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 4.78M (6.85%) | 82.52K Increased by +1.73% | Feb 28, 25 |
| 2 | US Small-Cap Growth II Equity Comp | 4.03M (5.78%) | 111.66K Increased by +2.77% | Dec 31, 24 |
| 3 | T. Rowe Price New Horizons | 3.96M (5.68%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 4 | Fidelity Growth Compy Commingled Pl O | 3.59M (5.15%) | 36.80K Increased by +1.02% | Aug 31, 24 |
| 5 | Fidelity Growth Company Fund | 3.40M (4.87%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 2.67M (3.83%) | 1.81K Increased by +0.07% | Feb 28, 25 |
| 7 | BB Biotech AG Ord | 2.49M (3.56%) | 353.98K Increased by +14.23% | Dec 31, 24 |
| 8 | Fidelity® Select Biotechnology | 2.49M (3.56%) | 428.93K Increased by +17.25% | Nov 30, 23 |
| 9 | Polar Capital Biotech S Inc | 2.38M (3.40%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 10 | Fidelity® Growth Company | 2.19M (3.13%) | 66.00K Increased by +3.02% | Nov 30, 23 |
| 11 | T. Rowe Price Health Sciences | 2.15M (3.08%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 12 | iShares Russell 2000 ETF | 2.12M (3.04%) | -18.37K Decreased by -0.87% | Mar 31, 25 |
| 13 | Fidelity Advisor® Biotechnology I | 1.67M (2.39%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 14 | Fidelity Select Biotechnology | 1.63M (2.34%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 15 | Eventide Gilead N | 1.46M (2.09%) | 78.66K Increased by +5.38% | Dec 31, 24 |
| 16 | SPDR® S&P Biotech ETF | 1.37M (1.96%) | -14.66K Decreased by -1.07% | Mar 31, 25 |
| 17 | T. Rowe Price Integrated US SmCapGrEq | 1.25M (1.79%) | 624.53K Increased by +50.00% | Dec 31, 24 |
| 18 | Eventide Healthcare & Life Sciences I | 1.19M (1.70%) | 167.87K Increased by +14.12% | Dec 31, 24 |
| 19 | Vanguard Institutional Extnd Mkt Idx Tr | 1.13M (1.62%) | 1.60K Increased by +0.14% | Feb 28, 25 |
| 20 | Hood River Small-Cap Growth Instl | 1.09M (1.57%) | -180.96K Decreased by -16.53% | Dec 31, 24 |