| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 13.64M (18.83%) | 3.44M Increased by +25.22% | Dec 31, 24 |
| 2 | Artal Group S A | 11.26M (15.55%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 3 | T. Rowe Price Associates, Inc. | 9.28M (12.82%) | 629.32K Increased by +6.78% | Dec 31, 24 |
| 4 | Siren, L.L.C. | 9.25M (12.77%) | -2.01M Decreased by -21.72% | Dec 31, 24 |
| 5 | BlackRock Inc | 7.17M (9.90%) | 1.02M Increased by +14.18% | Dec 31, 24 |
| 6 | Samsara BioCapital, LLC | 5.61M (7.75%) | -1.18M Decreased by -20.95% | Dec 31, 24 |
| 7 | Vanguard Group Inc | 4.74M (6.55%) | 708.82K Increased by +14.94% | Dec 31, 24 |
| 8 | Redmile Group, LLC | 4.55M (6.28%) | -688.96K Decreased by -15.14% | Dec 31, 24 |
| 9 | State Street Corporation | 4.17M (5.76%) | 2.01M Increased by +48.21% | Mar 31, 24 |
| 10 | Marshall Wace Asset Management Ltd | 2.95M (4.07%) | 2.73M Increased by +92.77% | Dec 31, 24 |
| 11 | Polar Capital Holdings PLC | 2.71M (3.74%) | -232.30K Decreased by -8.58% | Dec 31, 24 |
| 12 | Eventide Asset Management, LLC | 2.66M (3.67%) | 250.03K Increased by +9.40% | Dec 31, 24 |
| 13 | State Street Corp | 2.64M (3.64%) | -134.22K Decreased by -5.09% | Dec 31, 24 |
| 14 | Bellevue Group AG | 2.51M (3.47%) | 349.49K Increased by +13.92% | Dec 31, 24 |
| 15 | NORGES BANK | 1.99M (2.75%) | 1.99M Increased by +100.00% | Dec 31, 24 |
| 16 | Fairmount Funds Management LLC | 1.96M (2.71%) | 1.96M Increased by +100.00% | Dec 31, 24 |
| 17 | Hood River Capital Management LLC | 1.90M (2.62%) | -451.08K Decreased by -23.76% | Dec 31, 24 |
| 18 | Geode Capital Management, LLC | 1.77M (2.44%) | 227.30K Increased by +12.84% | Dec 31, 24 |
| 19 | Wellington Management Company LLP | 1.73M (2.38%) | 1.53M Increased by +88.42% | Dec 31, 24 |
| 20 | Goldman Sachs Group Inc | 1.72M (2.38%) | 321.38K Increased by +18.68% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 4.82M (6.66%) | 38.66K Increased by +0.80% | Mar 31, 25 |
| 2 | T. Rowe Price New Horizons | 3.82M (5.27%) | -142.86K Decreased by -3.74% | Mar 31, 25 |
| 3 | US Small-Cap Growth II Equity Comp | 3.82M (5.27%) | -212.11K Decreased by -5.55% | Mar 31, 25 |
| 4 | Fidelity Growth Compy Commingled Pl O | 3.59M (4.96%) | 36.80K Increased by +1.02% | Aug 31, 24 |
| 5 | Fidelity Growth Company Fund | 3.47M (4.80%) | 76.29K Increased by +2.20% | Mar 31, 25 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 2.68M (3.70%) | 9.71K Increased by +0.36% | Mar 31, 25 |
| 7 | BB Biotech AG Ord | 2.49M (3.43%) | 353.98K Increased by +14.23% | Dec 31, 24 |
| 8 | Fidelity® Select Biotechnology | 2.49M (3.43%) | 428.93K Increased by +17.25% | Nov 30, 23 |
| 9 | Polar Capital Biotech S Inc | 2.38M (3.28%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | Vanguard US Total Market Shares ETF | 2.29M (3.17%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | Fidelity® Growth Company | 2.19M (3.02%) | 66.00K Increased by +3.02% | Nov 30, 23 |
| 12 | T. Rowe Price Health Sciences | 2.03M (2.80%) | -121.77K Decreased by -6.01% | Mar 31, 25 |
| 13 | iShares Russell 2000 ETF | 1.98M (2.74%) | 335.00 Increased by +0.02% | Apr 30, 25 |
| 14 | Fidelity Advisor® Biotechnology I | 1.67M (2.30%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 15 | Fidelity Select Biotechnology | 1.63M (2.25%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | Eventide Gilead N | 1.46M (2.02%) | 78.66K Increased by +5.38% | Dec 31, 24 |
| 17 | SPDR® S&P Biotech ETF | 1.33M (1.84%) | -19.55K Decreased by -1.46% | Apr 30, 25 |
| 18 | T. Rowe Price Integrated US SmCapGrEq | 1.25M (1.72%) | 624.53K Increased by +50.00% | Dec 31, 24 |
| 19 | Eventide Healthcare & Life Sciences I | 1.19M (1.64%) | 167.87K Increased by +14.12% | Dec 31, 24 |
| 20 | Vanguard Institutional Extnd Mkt Idx Tr | 1.13M (1.56%) | 4.18K Increased by +0.37% | Mar 31, 25 |