| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 13.83M (17.26%) | 40.38K Increased by +0.29% | Jun 30, 25 |
| 2 | Artal Group S A | 11.26M (14.05%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 3 | Siren, L.L.C. | 9.25M (11.54%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | T. Rowe Price Associates, Inc. | 8.76M (10.93%) | -132.24K Decreased by -1.51% | Jun 30, 25 |
| 5 | BlackRock Inc | 6.70M (8.36%) | -611.39K Decreased by -9.13% | Jun 30, 25 |
| 6 | Samsara BioCapital, LLC | 5.61M (7.00%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 7 | Vanguard Group Inc | 4.86M (6.07%) | 16.39K Increased by +0.34% | Jun 30, 25 |
| 8 | State Street Corporation | 4.17M (5.20%) | 2.01M Increased by +48.21% | Mar 31, 24 |
| 9 | Redmile Group, LLC | 3.93M (4.90%) | -469.24K Decreased by -11.94% | Jun 30, 25 |
| 10 | State Street Corp | 3.07M (3.84%) | -59.84K Decreased by -1.95% | Jun 30, 25 |
| 11 | Bellevue Group AG | 2.95M (3.68%) | 440.40K Increased by +14.94% | Jun 30, 25 |
| 12 | Eventide Asset Management, LLC | 2.91M (3.64%) | 251.64K Increased by +8.64% | Jun 30, 25 |
| 13 | HHG PLC | 2.45M (3.06%) | 780.10K Increased by +31.84% | Jun 30, 25 |
| 14 | Wellington Management Company LLP | 2.02M (2.53%) | 179.87K Increased by +8.88% | Jun 30, 25 |
| 15 | Adage Capital Partners Gp LLC | 2.02M (2.52%) | 423.13K Increased by +20.97% | Mar 31, 25 |
| 16 | NORGES BANK | 1.99M (2.48%) | 1.99M Increased by +100.00% | Dec 31, 24 |
| 17 | Hood River Capital Management LLC | 1.97M (2.46%) | 30.81K Increased by +1.56% | Jun 30, 25 |
| 18 | Geode Capital Management, LLC | 1.89M (2.36%) | 39.96K Increased by +2.12% | Jun 30, 25 |
| 19 | Fairmount Funds Management LLC | 1.82M (2.28%) | 450.00K Increased by +24.67% | Jun 30, 25 |
| 20 | Citadel Advisors Llc | 1.72M (2.14%) | 934.59K Increased by +54.40% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 4.86M (6.07%) | 6.44K Increased by +0.13% | Jul 31, 25 |
| 2 | Fidelity Growth Compy Commingled Pl O | 3.59M (4.48%) | 36.80K Increased by +1.02% | Aug 31, 24 |
| 3 | US Small-Cap Growth II Equity Comp | 3.57M (4.46%) | -245.73K Decreased by -6.88% | Jun 30, 25 |
| 4 | Fidelity Growth Company Fund | 3.48M (4.34%) | -20.83K Decreased by -0.60% | Jul 31, 25 |
| 5 | T. Rowe Price New Horizons | 3.27M (4.09%) | -299.41K Decreased by -9.14% | Jul 31, 25 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 2.58M (3.21%) | -55.05K Decreased by -2.14% | Jul 31, 25 |
| 7 | BB Biotech AG Ord | 2.49M (3.10%) | 353.98K Increased by +14.23% | Dec 31, 24 |
| 8 | Fidelity® Select Biotechnology | 2.49M (3.10%) | 428.93K Increased by +17.25% | Nov 30, 23 |
| 9 | Vanguard US Total Market Shares ETF | 2.29M (2.86%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 10 | Fidelity® Growth Company | 2.19M (2.73%) | 66.00K Increased by +3.02% | Nov 30, 23 |
| 11 | iShares Russell 2000 ETF | 1.96M (2.44%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 12 | T. Rowe Price Health Sciences | 1.94M (2.43%) | -21.81K Decreased by -1.12% | Jul 31, 25 |
| 13 | Fidelity Advisor® Biotechnology I | 1.67M (2.08%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 14 | Fidelity Select Biotechnology | 1.63M (2.04%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 15 | Polar Capital Biotech S Inc | 1.50M (1.87%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 16 | Eventide Gilead N | 1.46M (1.82%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 17 | Eventide Healthcare & Life Sciences I | 1.44M (1.80%) | 251.00K Increased by +17.44% | Jun 30, 25 |
| 18 | T. Rowe Price Integrated US SmCapGrEq | 1.25M (1.56%) | 624.53K Increased by +50.00% | Dec 31, 24 |
| 19 | SPDR® S&P Biotech ETF | 1.22M (1.52%) | 2.71K Increased by +0.22% | Aug 31, 25 |
| 20 | T. Rowe Price New Horizons Tr-A | 1.16M (1.45%) | 120.24K Increased by +10.32% | Jun 30, 25 |