| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Perceptive Advisors LLC | 419.10M (752.52%) | 416.69M Increased by +99.42% | Sep 30, 25 |
| 2 | RA Capital Management, LLC | 6.67M (11.97%) | 985.48K Increased by +14.78% | Dec 31, 25 |
| 3 | BlackRock Inc | 6.30M (11.31%) | -4.88K Decreased by -0.08% | Dec 31, 25 |
| 4 | Vanguard Group Inc | 6.21M (11.15%) | 1.21M Increased by +19.55% | Dec 31, 25 |
| 5 | Baker Bros Advisors LP | 5.60M (10.06%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 6 | PRIMECAP Management Company | 3.42M (6.14%) | -61.16K Decreased by -1.79% | Mar 31, 26 |
| 7 | State Street Corporation | 3.01M (5.41%) | 807.82K Increased by +26.80% | Mar 31, 24 |
| 8 | NEA Management Company, LLC | 2.91M (5.22%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | State Street Corp | 2.20M (3.95%) | 169.96K Increased by +7.73% | Dec 31, 25 |
| 10 | Westfield Capital Management Company, L.P. | 1.93M (3.46%) | 661.97K Increased by +34.31% | Mar 31, 26 |
| 11 | The Goldman Sachs Group Inc | 1.83M (3.29%) | -62.80K Decreased by -3.43% | Dec 31, 25 |
| 12 | Goldman Sachs Group Inc | 1.73M (3.11%) | 95.81K Increased by +5.53% | Jun 30, 25 |
| 13 | FMR Inc | 1.71M (3.06%) | -438.87K Decreased by -25.72% | Dec 31, 25 |
| 14 | Federated Hermes Inc | 1.62M (2.92%) | -104.04K Decreased by -6.41% | Dec 31, 25 |
| 15 | T. Rowe Price Associates, Inc. | 1.56M (2.80%) | 160.95K Increased by +10.31% | Dec 31, 25 |
| 16 | JPMorgan Chase & Co | 1.55M (2.79%) | 129.66K Increased by +8.35% | Mar 31, 26 |
| 17 | Geode Capital Management, LLC | 1.38M (2.47%) | 12.90K Increased by +0.94% | Dec 31, 25 |
| 18 | Driehaus Capital Management LLC | 1.29M (2.31%) | -98.55K Decreased by -7.67% | Dec 31, 25 |
| 19 | Checkpoint Capital LP | 1.23M (2.20%) | 235.00K Increased by +19.15% | Mar 31, 26 |
| 20 | Polar Capital Holdings PLC | 1.19M (2.13%) | -59.54K Decreased by -5.02% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 2.18M (3.91%) | 63.43K Increased by +2.91% | Mar 31, 26 |
| 2 | PRIMECAP Odyssey Aggressive Growth | 2.12M (3.81%) | -32.46K Decreased by -1.53% | Mar 31, 26 |
| 3 | Vanguard US Total Market Shares ETF | 1.92M (3.45%) | 2.33K Increased by +0.12% | Sep 30, 24 |
| 4 | Vanguard Small Cap Index | 1.58M (2.83%) | 60.93K Increased by +3.86% | Mar 31, 26 |
| 5 | Polar Capital Biotech S Inc | 1.53M (2.74%) | 526.44K Increased by +34.49% | Mar 31, 26 |
| 6 | iShares Russell 2000 ETF | 1.24M (2.23%) | 10.48K Increased by +0.84% | Apr 30, 26 |
| 7 | American Funds SMALLCAP World A | 1.12M (2.01%) | 132.37K Increased by +11.82% | Mar 31, 26 |
| 8 | PRIMECAP Odyssey Growth | 1.11M (1.98%) | -29.40K Decreased by -2.66% | Mar 31, 26 |
| 9 | State Street® SPDR® S&P® Biotech ETF | 1.05M (1.89%) | -7.47K Decreased by -0.71% | Apr 30, 26 |
| 10 | Vanguard Small Cap Growth Index Inv | 882.89K (1.59%) | 41.19K Increased by +4.66% | Mar 31, 26 |
| 11 | Fidelity® Select Biotechnology | 786.90K (1.41%) | -75.80K Decreased by -9.63% | Nov 30, 23 |
| 12 | BGF World Healthscience A2 USD | 679.21K (1.22%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 678.82K (1.22%) | 16.71K Increased by +2.46% | Mar 31, 26 |
| 14 | Pictet Biotech | 659.88K (1.18%) | 659.88K Increased by +100.00% | Mar 31, 24 |
| 15 | BlackRock Health Sciences Term Trust | 630.46K (1.13%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | SPDR® S&P Biotech ETF | 630.00K (1.13%) | 1.41K Increased by +0.22% | Aug 31, 25 |
| 17 | JPM US Mid Cap Growth-Composite | 597.19K (1.07%) | 117.03K Increased by +19.60% | Mar 31, 26 |
| 18 | JPMorgan Mid Cap Growth I | 597.19K (1.07%) | 118.76K Increased by +19.89% | Mar 31, 26 |
| 19 | Federated Hermes Kaufmann Small Cap A | 592.00K (1.06%) | -81.00K Decreased by -13.68% | Mar 31, 26 |
| 20 | Federated Hermes Kaufmann Small Cap Grow | 592.00K (1.06%) | -81.00K Decreased by -13.68% | Mar 31, 26 |