| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Baker Bros Advisors LP | 11.05M (20.84%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 2 | T. Rowe Price Associates, Inc. | 10.96M (20.68%) | 1.08M Increased by +9.88% | Dec 31, 24 |
| 3 | State Street Corporation | 6.49M (12.24%) | 1.38M Increased by +21.20% | Mar 31, 24 |
| 4 | BlackRock Inc | 5.57M (10.50%) | 94.83K Increased by +1.70% | Dec 31, 24 |
| 5 | Redmile Group, LLC | 4.91M (9.26%) | 124.34K Increased by +2.53% | Dec 31, 24 |
| 6 | FCPM III SERVICES BV | 3.97M (7.49%) | -895.78K Decreased by -22.56% | Dec 31, 24 |
| 7 | Vanguard Group Inc | 3.60M (6.78%) | 129.60K Increased by +3.60% | Dec 31, 24 |
| 8 | Sofinnova Ventures | 3.15M (5.94%) | 3.10M Increased by +98.47% | Dec 31, 24 |
| 9 | TANG CAPITAL MANAGEMENT LLC | 2.70M (5.09%) | 1.50M Increased by +55.56% | Dec 31, 24 |
| 10 | State Street Corp | 2.20M (4.16%) | -135.99K Decreased by -6.17% | Dec 31, 24 |
| 11 | HHG PLC | 2.17M (4.09%) | 2.15M Increased by +99.17% | Sep 30, 23 |
| 12 | Bvf Inc | 2.14M (4.04%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 13 | RTW INVESTMENTS, LLC | 2.07M (3.90%) | 931.22K Increased by +45.10% | Dec 31, 24 |
| 14 | Omega Fund Management LLC | 1.98M (3.73%) | -486.12K Decreased by -24.61% | Dec 31, 24 |
| 15 | Boxer Capital Management, LLC | 1.80M (3.39%) | 1.80M Increased by +100.00% | Dec 31, 24 |
| 16 | Boxer Capital LLC | 1.54M (2.90%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 17 | BRAIDWELL LP | 1.48M (2.79%) | -1.59M Decreased by -107.90% | Dec 31, 24 |
| 18 | Geode Capital Management, LLC | 1.43M (2.70%) | 1.36K Increased by +0.10% | Dec 31, 24 |
| 19 | Camber Capital Management LLC | 1.35M (2.55%) | -1.40M Decreased by -103.70% | Jun 30, 24 |
| 20 | Loomis, Sayles & Company LP | 1.29M (2.43%) | 103.22K Increased by +8.00% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | US Small-Cap Growth II Equity Comp | 4.73M (8.92%) | 337.32K Increased by +7.13% | Dec 31, 24 |
| 2 | T. Rowe Price New Horizons | 4.73M (8.92%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 3 | T. Rowe Price Integrated US SmCapGrEq | 2.96M (5.59%) | 1.63M Increased by +54.85% | Dec 31, 24 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.99M (3.75%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 5 | iShares Russell 2000 ETF | 1.79M (3.38%) | -15.51K Decreased by -0.87% | Mar 31, 25 |
| 6 | T. Rowe Price Health Sciences | 1.70M (3.20%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 7 | T. Rowe Price Integrated US Sm Gr Eq | 1.48M (2.80%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 8 | T. Rowe Price New Horizons Tr-Z | 1.28M (2.41%) | 274.81K Increased by +21.52% | Dec 31, 24 |
| 9 | SPDR® S&P Biotech ETF | 962.98K (1.82%) | -10.31K Decreased by -1.07% | Mar 31, 25 |
| 10 | Vanguard Institutional Extnd Mkt Idx Tr | 899.14K (1.70%) | 10.74K Increased by +1.19% | Feb 28, 25 |
| 11 | Fidelity® Select Biotechnology | 825.12K (1.56%) | -31.60K Decreased by -3.83% | Nov 30, 23 |
| 12 | Janus Henderson Global Life Sciences | 638.89K (1.21%) | 638.89K Increased by +100.00% | Sep 30, 23 |
| 13 | Janus Henderson Global Life Sciences D | 638.89K (1.21%) | 638.89K Increased by +100.00% | Sep 30, 23 |
| 14 | iShares Russell 2000 Value ETF | 627.98K (1.18%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 15 | Candriam Global Equities Oncology | 612.16K (1.15%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 16 | Fidelity Small Cap Index | 606.58K (1.14%) | -11.36K Decreased by -1.87% | Jan 31, 25 |
| 17 | Nuveen Quant Small Cap Equity R6 | 521.99K (0.98%) | -3.63K Decreased by -0.70% | Jan 31, 25 |
| 18 | Direxion Daily S&P Biotech Bull 3X ETF | 501.66K (0.95%) | 3.54K Increased by +0.71% | Apr 30, 24 |
| 19 | T. Rowe Price Small-Cap Value | 497.43K (0.94%) | -1.00K Decreased by -0.20% | Sep 30, 23 |
| 20 | Janus Selection Global Life Science AUSD | 493.81K (0.93%) | 493.81K Increased by +100.00% | Sep 30, 23 |