| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Orbimed Advisors, LLC | 13.14M (22.47%) | 13.14M Increased by +100.00% | Dec 31, 24 |
| 2 | TCG Crossover Management, LLC | 13.14M (22.47%) | 13.14M Increased by +100.00% | Dec 31, 24 |
| 3 | Foresite Capital Management VI LLC | 12.50M (21.38%) | 12.50M Increased by +100.00% | Dec 31, 24 |
| 4 | RTW INVESTMENTS, LLC | 11.76M (20.13%) | 11.76M Increased by +100.00% | Dec 31, 24 |
| 5 | Bvf Inc | 9.24M (15.80%) | 9.24M Increased by +100.00% | Dec 31, 24 |
| 6 | Redmile Group, LLC | 6.48M (11.08%) | 5.97M Increased by +92.21% | Dec 31, 24 |
| 7 | Deep Track Capital, LP | 6.01M (10.28%) | 6.01M Increased by +100.00% | Dec 31, 24 |
| 8 | Perceptive Advisors LLC | 5.88M (10.06%) | 5.88M Increased by +100.00% | Dec 31, 24 |
| 9 | FMR Inc | 5.23M (8.95%) | -2.47K Decreased by -0.05% | Dec 31, 24 |
| 10 | Vanguard Group Inc | 2.94M (5.03%) | -214.66K Decreased by -7.30% | Dec 31, 24 |
| 11 | Morgan Stanley - Brokerage Accounts | 2.36M (4.03%) | -1.45M Decreased by -61.62% | Jun 30, 24 |
| 12 | BlackRock Inc | 2.30M (3.93%) | -199.99K Decreased by -8.70% | Dec 31, 24 |
| 13 | T. Rowe Price Associates, Inc. | 2.03M (3.47%) | -1.39M Decreased by -68.31% | Mar 31, 24 |
| 14 | Kingdon Capital Management LLC | 1.73M (2.95%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 15 | Column Group LLC | 1.33M (2.27%) | -1.35M Decreased by -101.76% | Dec 31, 24 |
| 16 | T. Rowe Price Investment Management,Inc. | 1.28M (2.19%) | 25.97K Increased by +2.03% | Dec 31, 23 |
| 17 | Nantahala Capital Management, LLC | 1.24M (2.13%) | 1.24M Increased by +100.00% | Dec 31, 24 |
| 18 | ADAR1 Capital Management LLC | 1.17M (2.01%) | 1.17M Increased by +99.36% | Dec 31, 24 |
| 19 | Great Point Partners LLC | 1.10M (1.88%) | -358.32K Decreased by -32.58% | Dec 31, 23 |
| 20 | BRAIDWELL LP | 1.08M (1.85%) | 98.11K Increased by +9.06% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 2.05M (3.51%) | 21.11K Increased by +1.03% | Dec 31, 24 |
| 2 | Fidelity Growth Compy Commingled Pl O | 2.00M (3.42%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 3 | Fidelity Growth Company Fund | 1.49M (2.56%) | -18.17K Decreased by -1.22% | Dec 31, 24 |
| 4 | T. Rowe Price New Horizons | 1.38M (2.36%) | -636.91K Decreased by -46.23% | Mar 31, 24 |
| 5 | US Small-Cap Growth II Equity Comp | 1.38M (2.36%) | -636.91K Decreased by -46.23% | Mar 31, 24 |
| 6 | Fidelity® Growth Company | 1.09M (1.86%) | 34.40K Increased by +3.16% | Nov 30, 23 |
| 7 | Vanguard Total Stock Mkt Idx Inv | 1.05M (1.79%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 8 | Fidelity® Select Biotechnology | 802.70K (1.37%) | -70.10K Decreased by -8.73% | Nov 30, 23 |
| 9 | SPDR® S&P Biotech ETF | 799.62K (1.37%) | -10.60K Decreased by -1.33% | Jan 31, 24 |
| 10 | UBS: US Equity Small Cap Growth | 749.72K (1.28%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 11 | iShares Russell 2000 ETF | 744.95K (1.27%) | -6.43K Decreased by -0.86% | Mar 31, 25 |
| 12 | Xtrackers S&P 500 Swap ETF 1C | 647.09K (1.11%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 13 | T. Rowe Price Health Sciences | 502.89K (0.86%) | -109.19K Decreased by -21.71% | Dec 31, 23 |
| 14 | FIAM Small Cap Core Composite | 495.40K (0.85%) | -7.10K Decreased by -1.43% | Sep 30, 23 |
| 15 | Fidelity Growth Company K6 | 481.38K (0.82%) | -2.94K Decreased by -0.61% | Dec 31, 24 |
| 16 | T. Rowe Price Small-Cap Stock | 466.32K (0.80%) | -700.00 Decreased by -0.15% | Dec 31, 23 |
| 17 | T. Rowe Price US Small-Cap Core Equity | 466.32K (0.80%) | -700.00 Decreased by -0.15% | Dec 31, 23 |
| 18 | Federated Hermes MDT SCC Institutional | 461.23K (0.79%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 19 | Federated Hermes MDT Small Cap Core IS | 461.23K (0.79%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 20 | Vanguard Institutional Extnd Mkt Idx Tr | 458.85K (0.79%) | 0.00 Increased by 0.00% | Feb 28, 25 |