| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HHG PLC | 2.76M (10.72%) | 230.45K Increased by +8.34% | Sep 30, 25 |
| 2 | BlackRock Inc | 1.80M (6.99%) | 210.95K Increased by +11.71% | Sep 30, 25 |
| 3 | Perceptive Advisors LLC | 1.56M (6.07%) | 811.63K Increased by +51.88% | Sep 30, 25 |
| 4 | Vida Ventures Advisors, LLC | 1.47M (5.70%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 5 | Vanguard Group Inc | 1.46M (5.67%) | 193.65K Increased by +13.26% | Dec 31, 25 |
| 6 | FMR Inc | 1.36M (5.27%) | 1.32M Increased by +96.82% | Dec 31, 25 |
| 7 | Orbis Allan Gray Ltd | 1.26M (4.87%) | 1.26M Increased by +100.00% | Dec 31, 25 |
| 8 | Baker Bros Advisors LP | 1.13M (4.37%) | 437.00K Increased by +38.79% | Dec 31, 25 |
| 9 | T. Rowe Price Associates, Inc. | 1.00M (3.89%) | -469.58K Decreased by -46.80% | Sep 30, 25 |
| 10 | VR Adviser, LLC | 989.99K (3.84%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 11 | Adage Capital Partners Gp LLC | 965.31K (3.74%) | -1.41M Decreased by -145.94% | Dec 31, 25 |
| 12 | Cormorant Asset Management, LLC | 950.00K (3.69%) | -50.00K Decreased by -5.26% | Dec 31, 25 |
| 13 | Driehaus Capital Management LLC | 933.06K (3.62%) | 432.51K Increased by +46.35% | Dec 31, 25 |
| 14 | State Street Corp | 907.11K (3.52%) | 209.01K Increased by +23.04% | Sep 30, 25 |
| 15 | Deerfield Management Co | 903.35K (3.50%) | 62.50K Increased by +6.92% | Dec 31, 25 |
| 16 | Soleus Capital Management, L.P. | 859.17K (3.33%) | -107.57K Decreased by -12.52% | Sep 30, 25 |
| 17 | Capital Research Global Investors | 853.75K (3.31%) | -139.82K Decreased by -16.38% | Mar 31, 25 |
| 18 | RA Capital Management, LLC | 761.96K (2.96%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 19 | The Goldman Sachs Group Inc | 716.18K (2.78%) | 123.16K Increased by +17.20% | Dec 31, 25 |
| 20 | Jacobs Levy Equity Management, Inc. | 683.38K (2.65%) | -624.14K Decreased by -91.33% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 885.47K (3.43%) | 24.55K Increased by +2.77% | Mar 31, 26 |
| 2 | American Funds SMALLCAP World A | 748.24K (2.90%) | -139.82K Decreased by -18.69% | Mar 31, 25 |
| 3 | iShares Russell 2000 ETF | 625.48K (2.43%) | -5.12K Decreased by -0.82% | Mar 31, 26 |
| 4 | Vanguard US Total Market Shares ETF | 541.27K (2.10%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | Janus Henderson Global Life Sciences | 433.76K (1.68%) | 51.26K Increased by +11.82% | Dec 31, 25 |
| 6 | Janus Henderson Global Life Sciences D | 416.52K (1.62%) | -17.23K Decreased by -4.14% | Jan 31, 26 |
| 7 | Fidelity Select Biotechnology | 390.50K (1.51%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 8 | Renaissance Global Health Care | 388.36K (1.51%) | 0.00 Increased by 0.00% | May 31, 25 |
| 9 | Janus Global Life Science AUSD | 372.47K (1.44%) | 49.09K Increased by +13.18% | Dec 31, 25 |
| 10 | Janus Henderson Glb Life Scn I2 USD | 367.83K (1.43%) | -2.61K Decreased by -0.71% | Feb 28, 26 |
| 11 | Vanguard Small Cap Index | 321.69K (1.25%) | 321.69K Increased by +100.00% | Mar 31, 26 |
| 12 | Janus Henderson Hrzn Biotec E2 USD | 315.29K (1.22%) | 103.18K Increased by +32.73% | Dec 31, 25 |
| 13 | BlackRock Extended Mkt Composite | 303.70K (1.18%) | 219.02K Increased by +72.12% | Sep 30, 23 |
| 14 | SPDR® S&P Biotech ETF | 302.24K (1.17%) | 675.00 Increased by +0.22% | Aug 31, 25 |
| 15 | State Street® SPDR® S&P® Biotech ETF | 298.54K (1.16%) | 17.59K Increased by +5.89% | Mar 31, 26 |
| 16 | Vanguard Institutional Extnd Mkt Idx Tr | 287.77K (1.12%) | 8.89K Increased by +3.09% | Mar 31, 26 |
| 17 | Orbis Global Equity Investor | 271.91K (1.05%) | 271.91K Increased by +100.00% | Dec 31, 25 |
| 18 | T. Rowe Price Integrated US Sm Gr Eq | 258.45K (1.00%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 19 | T. Rowe Price Integrated US SmCapGrEq | 258.45K (1.00%) | 97.40K Increased by +37.69% | Jun 30, 25 |
| 20 | Janus Henderson US SMID Cap Growth | 246.75K (0.96%) | 246.75K Increased by +100.00% | Dec 31, 25 |