| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 12.47M (20.99%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Medicxi Ventures Management (Jersey) Ltd | 7.46M (12.57%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Jennison Associates LLC | 7.04M (11.86%) | -20.18K Decreased by -0.29% | Mar 31, 25 |
| 4 | Amvescap Plc. | 3.86M (6.51%) | -275.10K Decreased by -7.12% | Sep 30, 25 |
| 5 | The Carlyle Group Inc | 3.50M (5.89%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 6 | BlackRock Inc | 3.40M (5.73%) | 86.98K Increased by +2.56% | Sep 30, 25 |
| 7 | Vanguard Group Inc | 3.18M (5.35%) | -38.36K Decreased by -1.21% | Dec 31, 25 |
| 8 | Ensign Peak Advisors Inc | 2.35M (3.96%) | -151.32K Decreased by -6.43% | Dec 31, 25 |
| 9 | Checkpoint Capital LP | 2.27M (3.83%) | 769.85K Increased by +33.85% | Dec 31, 24 |
| 10 | Millennium Management LLC | 2.08M (3.51%) | -3.00M Decreased by -144.04% | Dec 31, 25 |
| 11 | NEA Management Company, LLC | 1.96M (3.30%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | 683 Capital Management LLC | 1.78M (3.01%) | -35.38K Decreased by -1.98% | Dec 31, 25 |
| 13 | Portolan Capital Management, LLC | 1.70M (2.86%) | 569.83K Increased by +33.52% | Sep 30, 24 |
| 14 | Gilder Gagnon Howe & CO LLC | 1.62M (2.73%) | 150.62K Increased by +9.28% | Sep 30, 24 |
| 15 | Orbimed Advisors, LLC | 1.45M (2.44%) | 1.45M Increased by +100.00% | Sep 30, 24 |
| 16 | Catalys Pacific LLC | 1.43M (2.41%) | 261.90K Increased by +18.33% | Dec 31, 25 |
| 17 | Federated Hermes Inc | 1.40M (2.36%) | 1.40M Increased by +100.00% | Sep 30, 24 |
| 18 | Wasatch Advisors LP | 1.33M (2.24%) | -205.55K Decreased by -15.44% | Dec 31, 25 |
| 19 | GW&K Investment Management, LLC | 1.31M (2.20%) | 162.35K Increased by +12.42% | Dec 31, 25 |
| 20 | Decheng Capital LLC | 1.25M (2.10%) | 400.00K Increased by +32.00% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Invesco Global A | 2.34M (3.94%) | 367.07K Increased by +15.67% | Jan 31, 26 |
| 2 | Invesco OFI Global Equity | 1.98M (3.33%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 1.96M (3.30%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 4 | Jennison Health Sciences Equity | 1.78M (3.00%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | Vanguard US Total Market Shares ETF | 1.65M (2.77%) | 280.90K Increased by +17.06% | Sep 30, 24 |
| 6 | Jennison SMid Cap Core Equity | 1.58M (2.66%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 7 | Strategic Advisers U.S. Total Stock{mg} | 1.48M (2.48%) | -273.72K Decreased by -18.55% | Sep 30, 24 |
| 8 | Strategic Advisers Small-Mid Cap | 1.24M (2.09%) | 278.88K Increased by +22.43% | Jul 31, 24 |
| 9 | PGIM Jennison Small Company A | 1.21M (2.03%) | -373.30K Decreased by -30.96% | Apr 30, 25 |
| 10 | iShares Russell 2000 ETF | 1.11M (1.87%) | -9.07K Decreased by -0.82% | Mar 31, 26 |
| 11 | Strategic Advisers U.S. Total Stock | 968.54K (1.63%) | 59.72K Increased by +6.17% | Feb 28, 26 |
| 12 | PGIM Jennison Health Sciences Z | 867.63K (1.46%) | -913.72K Decreased by -105.31% | Apr 30, 25 |
| 13 | Biotech Growth Ord | 847.90K (1.43%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 14 | Wasatch Micro Cap | 749.13K (1.26%) | 51.16K Increased by +6.83% | Dec 31, 25 |
| 15 | Federated Hermes Kaufmann Growth | 690.00K (1.16%) | 690.00K Increased by +100.00% | Sep 30, 24 |
| 16 | Federated Hermes Kaufmann R | 690.00K (1.16%) | 690.00K Increased by +100.00% | Sep 30, 24 |
| 17 | AZ InvestEd Ivy Small Cap Growth E | 666.39K (1.12%) | 666.39K Increased by +100.00% | Jan 31, 26 |
| 18 | Federated Hermes Kaufmann Small Cap A | 550.00K (0.93%) | 550.00K Increased by +100.00% | Sep 30, 24 |
| 19 | Federated Hermes Kaufmann Small Cap Grow | 550.00K (0.93%) | 550.00K Increased by +100.00% | Sep 30, 24 |
| 20 | Wasatch Ultra Growth | 543.84K (0.92%) | -174.98K Decreased by -32.18% | Dec 31, 25 |