| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | COMMODORE CAPITAL LP | 11.45M (10.86%) | 11.45M Increased by +100.00% | Dec 31, 25 |
| 2 | Octagon Capital Advisors LP | 9.57M (9.08%) | 9.57M Increased by +100.00% | Dec 31, 25 |
| 3 | RA Capital Management, LLC | 7.12M (6.76%) | 7.12M Increased by +100.00% | Dec 31, 25 |
| 4 | Boxer Capital Management, LLC | 4.80M (4.55%) | 4.80M Increased by +100.00% | Dec 31, 25 |
| 5 | Adage Capital Partners Gp LLC | 4.50M (4.27%) | 4.50M Increased by +100.00% | Dec 31, 25 |
| 6 | B Group, Inc | 4.50M (4.27%) | 4.50M Increased by +100.00% | Dec 31, 25 |
| 7 | StemPoint Capital LP | 4.19M (3.98%) | 4.19M Increased by +100.00% | Dec 31, 25 |
| 8 | Renaissance Technologies Corp | 2.38M (2.26%) | 2.38M Increased by +100.00% | Dec 31, 25 |
| 9 | Vivo Capital, LLC | 2.29M (2.18%) | 2.29M Increased by +100.00% | Dec 31, 25 |
| 10 | Vanguard Group Inc | 2.12M (2.01%) | 2.12M Increased by +100.00% | Dec 31, 25 |
| 11 | ADAR1 Capital Management LLC | 2.00M (1.90%) | 2.00M Increased by +100.00% | Dec 31, 25 |
| 12 | Artia Global Partners LP | 1.99M (1.89%) | 1.99M Increased by +100.00% | Dec 31, 25 |
| 13 | HighVista Strategies LLC | 1.30M (1.23%) | 1.30M Increased by +100.00% | Dec 31, 25 |
| 14 | Exome Asset Management LLC | 758.20K (0.72%) | 758.20K Increased by +100.00% | Dec 31, 25 |
| 15 | Hudson Bay Capital Management LP | 656.46K (0.62%) | 656.46K Increased by +100.00% | Dec 31, 25 |
| 16 | Persistent Asset Partners Limited | 416.04K (0.39%) | 416.04K Increased by +100.00% | Dec 31, 25 |
| 17 | Resolute Capital Asset Partners LLC | 400.00K (0.38%) | 400.00K Increased by +100.00% | Dec 31, 25 |
| 18 | Balyasny Asset Management LLC | 325.37K (0.31%) | 325.37K Increased by +100.00% | Dec 31, 25 |
| 19 | Squarepoint Ops LLC | 322.09K (0.31%) | 322.09K Increased by +100.00% | Dec 31, 25 |
| 20 | Creek Drive Management Group LLC | 307.50K (0.29%) | 307.50K Increased by +100.00% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Franklin Biotechnology Discv A(acc)USD | 3.35M (3.18%) | 452.60K Increased by +13.50% | Dec 31, 25 |
| 2 | Franklin Biotechnology Discovery A | 2.12M (2.01%) | 222.11K Increased by +10.48% | Jan 31, 26 |
| 3 | Biotech Growth Ord | 1.87M (1.78%) | 1.44M Increased by +76.76% | Nov 30, 25 |
| 4 | Vanguard Institutional Extnd Mkt Idx Tr | 1.38M (1.31%) | -20.00K Decreased by -1.45% | Jan 31, 26 |
| 5 | Fidelity Extended Market Index | 680.62K (0.65%) | -2.83K Decreased by -0.42% | Jan 31, 26 |
| 6 | Blackrock Extended Mkt Fund CF | 376.09K (0.36%) | 376.09K Increased by +100.00% | Jan 31, 26 |
| 7 | Simplify Propel Opportunities ETF | 350.00K (0.33%) | 0.00 Increased by 0.00% | Feb 27, 26 |
| 8 | Extended Equity Market Fund K | 322.57K (0.31%) | 322.57K Increased by +100.00% | Dec 31, 25 |
| 9 | Fidelity Total Market Index | 269.21K (0.26%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 10 | Fidelity Series Total Market Index | 230.28K (0.22%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 11 | Spartan Extended Market Index Pool F | 184.02K (0.17%) | 2.83K Increased by +1.54% | Jan 31, 26 |
| 12 | NT Ext Equity Mkt Idx Fd - L | 152.02K (0.14%) | 149.91K Increased by +98.61% | Dec 31, 25 |
| 13 | NT Ext Equity Mkt Idx Fd - NL | 126.22K (0.12%) | 126.21K Increased by +99.99% | Dec 31, 25 |
| 14 | Spartan Total Market Index Pool G | 109.17K (0.10%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 15 | LUX IM Global Medtech HX | 100.00K (0.09%) | 100.00K Increased by +100.00% | Jan 31, 26 |
| 16 | NT Ext Equity Mkt Idx Fd - DC - NL - T2 | 99.41K (0.09%) | 99.40K Increased by +99.99% | Dec 31, 25 |
| 17 | Fidelity Nasdaq Composite Index | 89.92K (0.09%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 18 | NT Ext Eq Mkt Indx Fd DC Lending Tier 5 | 59.57K (0.06%) | 58.98K Increased by +99.00% | Dec 31, 25 |
| 19 | Vanguard U.S. Eq Idx £ Acc | 52.29K (0.05%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 20 | Virtus Systematic U.S. Small Cap | 46.00K (0.04%) | 46.00K Increased by +100.00% | Dec 31, 25 |