| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 18.70M (10.75%) | 18.70M Increased by +100.00% | Sep 30, 23 |
| 2 | BlackRock Inc | 16.09M (9.25%) | 122.24K Increased by +0.76% | Dec 31, 24 |
| 3 | Vanguard Group Inc | 12.33M (7.09%) | -792.77K Decreased by -6.43% | Dec 31, 24 |
| 4 | Samlyn Capital, LLC | 9.67M (5.56%) | 467.10K Increased by +4.83% | Dec 31, 24 |
| 5 | Nantahala Capital Management, LLC | 7.81M (4.49%) | 3.70M Increased by +47.38% | Dec 31, 24 |
| 6 | Acadian Asset Management LLC | 7.57M (4.35%) | -249.74K Decreased by -3.30% | Mar 31, 24 |
| 7 | Citadel Advisors Llc | 6.95M (4.00%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 8 | Eventide Asset Management, LLC | 6.65M (3.82%) | -2.75M Decreased by -41.35% | Dec 31, 24 |
| 9 | PRIMECAP Management Company | 5.54M (3.18%) | -372.07K Decreased by -6.72% | Dec 31, 24 |
| 10 | Woodline Partners LP | 4.97M (2.86%) | 3.24M Increased by +65.19% | Dec 31, 24 |
| 11 | Millennium Management LLC | 4.52M (2.60%) | -536.77K Decreased by -11.86% | Dec 31, 24 |
| 12 | TCG Crossover Management, LLC | 4.00M (2.30%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 13 | Geode Capital Management, LLC | 3.96M (2.27%) | -5.50K Decreased by -0.14% | Dec 31, 24 |
| 14 | TANG CAPITAL MANAGEMENT LLC | 3.94M (2.26%) | 3.80M Increased by +96.46% | Sep 30, 23 |
| 15 | Renaissance Technologies Corp | 3.91M (2.25%) | 583.15K Increased by +14.91% | Dec 31, 24 |
| 16 | Stonepine Capital Management Llc | 3.48M (2.00%) | 3.48M Increased by +100.00% | Mar 31, 24 |
| 17 | State Street Corp | 3.27M (1.88%) | -73.63K Decreased by -2.25% | Dec 31, 24 |
| 18 | Altium Capital Management, LP | 3.00M (1.72%) | 2.99M Increased by +99.62% | Dec 31, 24 |
| 19 | Morgan Stanley - Brokerage Accounts | 2.95M (1.69%) | 2.61M Increased by +88.54% | Jun 30, 24 |
| 20 | Jacobs Levy Equity Management, Inc. | 2.63M (1.51%) | -166.24K Decreased by -6.33% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Eventide Healthcare & Life Sciences I | 6.65M (3.82%) | -2.75M Decreased by -41.35% | Dec 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 5.72M (3.29%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 3 | iShares Russell 2000 ETF | 4.89M (2.81%) | -42.35K Decreased by -0.87% | Mar 31, 25 |
| 4 | PRIMECAP Odyssey Aggressive Growth | 3.54M (2.03%) | -156.31K Decreased by -4.42% | Dec 31, 24 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 2.66M (1.53%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 6 | Pictet Biopharmaceutical Mother | 1.85M (1.06%) | 999.77K Increased by +54.15% | Apr 13, 23 |
| 7 | Fidelity Small Cap Index | 1.79M (1.03%) | -33.51K Decreased by -1.87% | Jan 31, 25 |
| 8 | iShares Russell 2000 Value ETF | 1.70M (0.97%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 9 | Vanguard Strategic Equity Inv | 1.52M (0.87%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 10 | PRIMECAP Odyssey Growth | 1.44M (0.83%) | -165.00K Decreased by -11.42% | Dec 31, 24 |
| 11 | Bridgeway Ultra-Small Company | 1.29M (0.74%) | -70.00K Decreased by -5.42% | Dec 31, 24 |
| 12 | BlackRock Advantage Small Cap Core Instl | 1.01M (0.58%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 13 | Fidelity® Extended Market Index | 921.63K (0.53%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 14 | State St Russell Sm/Mid Cp® Indx NL Cl C | 913.93K (0.53%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 15 | Fidelity Extended Market Index | 885.86K (0.51%) | 56.27K Increased by +6.35% | Feb 28, 25 |
| 16 | Vanguard Russell 2000 ETF | 816.33K (0.47%) | 19.04K Increased by +2.33% | Feb 28, 25 |
| 17 | Vanguard Strategic Small-Cap Equity Inv | 763.31K (0.44%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 18 | Schwab US Small-Cap ETF™ | 760.26K (0.44%) | 2.80K Increased by +0.37% | Mar 29, 25 |
| 19 | State St Russell Sm Cap® Indx SL Cl I | 614.40K (0.35%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 20 | Vanguard Health Care ETF | 565.83K (0.33%) | -1.44K Decreased by -0.25% | Oct 31, 24 |