| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 18.70M (64.17%) | 18.70M Increased by +100.00% | Sep 30, 23 |
| 2 | Samlyn Capital, LLC | 9.67M (33.17%) | 467.10K Increased by +4.83% | Dec 31, 24 |
| 3 | Acadian Asset Management LLC | 7.30M (25.06%) | 7.23M Increased by +99.07% | Mar 31, 25 |
| 4 | Eventide Asset Management, LLC | 6.65M (22.82%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | Almitas Capital LLC | 4.61M (15.82%) | 3.69M Increased by +80.04% | Mar 31, 25 |
| 6 | FMR Inc | 4.30M (14.77%) | 4.20M Increased by +97.65% | Mar 31, 26 |
| 7 | TANG CAPITAL MANAGEMENT LLC | 3.94M (13.52%) | 3.80M Increased by +96.46% | Sep 30, 23 |
| 8 | Stonepine Capital Management Llc | 3.48M (11.94%) | 3.48M Increased by +100.00% | Mar 31, 24 |
| 9 | State Street Corp | 3.26M (11.18%) | -13.81K Decreased by -0.42% | Mar 31, 25 |
| 10 | Bvf Inc | 2.56M (8.78%) | 1.00M Increased by +39.07% | Mar 31, 26 |
| 11 | D. E. Shaw & Co LP | 2.55M (8.75%) | -3.57M Decreased by -140.21% | Mar 31, 24 |
| 12 | Exome Asset Management LLC | 2.23M (7.66%) | 1.61M Increased by +72.31% | Mar 31, 25 |
| 13 | Monaco Asset Management | 2.03M (6.98%) | 35.65K Increased by +1.75% | Dec 31, 24 |
| 14 | GSA Capital Partners LLP | 1.99M (6.83%) | -3.27M Decreased by -164.12% | Mar 31, 24 |
| 15 | Deep Track Capital, LP | 1.98M (6.78%) | -13.95M Decreased by -705.80% | Dec 31, 24 |
| 16 | Two Seas Capital LP | 1.96M (6.72%) | 1.21M Increased by +61.96% | Mar 31, 26 |
| 17 | Goldman Sachs Group Inc | 1.78M (6.12%) | 15.95K Increased by +0.89% | Sep 30, 24 |
| 18 | Verition Fund Managegment, LLC | 1.74M (5.98%) | 1.65M Increased by +94.84% | Sep 30, 23 |
| 19 | Assenagon Asset Management SA | 1.69M (5.79%) | -778.97K Decreased by -46.17% | Mar 31, 24 |
| 20 | Mackenzie Investments | 1.66M (5.69%) | 719.21K Increased by +43.36% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Eventide Healthcare & Life Sciences I | 6.65M (22.82%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 5.72M (19.64%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | iShares Russell 2000 ETF | 4.62M (15.85%) | 0.00 Increased by 0.00% | May 31, 25 |
| 4 | Fidelity Growth Compy Commingled Pl S | 2.23M (7.65%) | 367.50K Increased by +16.48% | Apr 30, 26 |
| 5 | Pictet Biopharmaceutical Mother | 1.85M (6.34%) | 999.77K Increased by +54.15% | Apr 13, 23 |
| 6 | Fidelity Small Cap Index | 1.83M (6.27%) | 0.00 Increased by 0.00% | May 31, 25 |
| 7 | Fidelity Growth Company Fund | 1.79M (6.14%) | 180.10K Increased by +10.07% | Apr 30, 26 |
| 8 | iShares Russell 2000 Value ETF | 1.66M (5.71%) | 0.00 Increased by 0.00% | May 31, 25 |
| 9 | Vanguard Total Stock Mkt Idx Inv | 1.03M (3.52%) | 170.20K Increased by +16.59% | Apr 30, 26 |
| 10 | Fidelity® Extended Market Index | 921.63K (3.16%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 11 | State St Russell Sm/Mid Cp® Indx NL Cl C | 913.93K (3.14%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 12 | State St Russell Sm/Mid Cp® Indx SL Cl I | 913.93K (3.14%) | 0.00 Increased by 0.00% | May 31, 25 |
| 13 | Vanguard Russell 2000 ETF | 892.48K (3.06%) | 8.00K Increased by +0.90% | May 31, 25 |
| 14 | Mackenzie US Small Cap F8 | 706.38K (2.42%) | 47.20K Increased by +6.68% | Apr 30, 25 |
| 15 | Mackenzie US Small Cap A | 659.17K (2.26%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | State St Russell Sm Cap® Indx SL Cl I | 614.40K (2.11%) | 0.00 Increased by 0.00% | May 31, 25 |
| 17 | A4Investments SICAV SIF ACCI IlanaA2EURH | 550.00K (1.89%) | 0.00 Increased by 0.00% | Jan 31, 24 |
| 18 | BlackRock Extended Mkt Composite | 538.85K (1.85%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 19 | Invesco FTSE RAFI US 1500 Small-Mid ETF | 531.74K (1.82%) | 0.00 Increased by 0.00% | Feb 27, 25 |
| 20 | Fidelity Growth Company K6 | 478.99K (1.64%) | 42.30K Increased by +8.83% | Apr 30, 26 |