| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 18.70M (10.19%) | 18.70M Increased by +100.00% | Sep 30, 23 |
| 2 | BlackRock Inc | 15.71M (8.56%) | -384.26K Decreased by -2.45% | Mar 31, 25 |
| 3 | Vanguard Group Inc | 12.31M (6.71%) | -18.33K Decreased by -0.15% | Mar 31, 25 |
| 4 | Samlyn Capital, LLC | 9.67M (5.27%) | 467.10K Increased by +4.83% | Dec 31, 24 |
| 5 | Nantahala Capital Management, LLC | 7.79M (4.24%) | -20.95K Decreased by -0.27% | Mar 31, 25 |
| 6 | Acadian Asset Management LLC | 7.57M (4.12%) | -249.74K Decreased by -3.30% | Mar 31, 24 |
| 7 | Citadel Advisors Llc | 6.95M (3.79%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 8 | Eventide Asset Management, LLC | 6.65M (3.62%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 9 | PRIMECAP Management Company | 5.35M (2.92%) | -185.80K Decreased by -3.47% | Mar 31, 25 |
| 10 | Renaissance Technologies Corp | 4.70M (2.56%) | 791.00K Increased by +16.82% | Mar 31, 25 |
| 11 | Millennium Management LLC | 4.52M (2.47%) | -536.77K Decreased by -11.86% | Dec 31, 24 |
| 12 | Geode Capital Management, LLC | 4.01M (2.18%) | 51.54K Increased by +1.29% | Mar 31, 25 |
| 13 | TCG Crossover Management, LLC | 4.00M (2.18%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 14 | TANG CAPITAL MANAGEMENT LLC | 3.94M (2.15%) | 3.80M Increased by +96.46% | Sep 30, 23 |
| 15 | Woodline Partners LP | 3.69M (2.01%) | -1.28M Decreased by -34.74% | Mar 31, 25 |
| 16 | AQR Capital Management LLC | 3.64M (1.98%) | 2.81M Increased by +77.11% | Mar 31, 25 |
| 17 | Stonepine Capital Management Llc | 3.48M (1.90%) | 3.48M Increased by +100.00% | Mar 31, 24 |
| 18 | State Street Corp | 3.26M (1.78%) | -13.81K Decreased by -0.42% | Mar 31, 25 |
| 19 | Jacobs Levy Equity Management, Inc. | 3.01M (1.64%) | 380.97K Increased by +12.67% | Mar 31, 25 |
| 20 | Altium Capital Management, LP | 3.00M (1.63%) | 2.99M Increased by +99.62% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Eventide Healthcare & Life Sciences I | 6.65M (3.62%) | -2.75M Decreased by -41.35% | Dec 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 5.72M (3.12%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 3 | Vanguard US Total Market Shares ETF | 5.72M (3.12%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 4.56M (2.49%) | 770.00 Increased by +0.02% | Apr 30, 25 |
| 5 | PRIMECAP Odyssey Aggressive Growth | 3.46M (1.89%) | -72.30K Decreased by -2.09% | Mar 31, 25 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 2.66M (1.45%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 7 | Pictet Biopharmaceutical Mother | 1.85M (1.01%) | 999.77K Increased by +54.15% | Apr 13, 23 |
| 8 | Fidelity Small Cap Index | 1.79M (0.98%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 9 | iShares Russell 2000 Value ETF | 1.72M (0.94%) | -5.85K Decreased by -0.34% | Apr 30, 25 |
| 10 | Vanguard Strategic Equity Inv | 1.52M (0.83%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 11 | PRIMECAP Odyssey Growth | 1.37M (0.74%) | -78.90K Decreased by -5.78% | Mar 31, 25 |
| 12 | BlackRock Advantage Small Cap Core Instl | 1.01M (0.55%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 13 | Bridgeway Ultra-Small Company | 992.10K (0.54%) | -300.00K Decreased by -30.24% | Mar 31, 25 |
| 14 | Fidelity® Extended Market Index | 921.63K (0.50%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 15 | State St Russell Sm/Mid Cp® Indx NL Cl C | 913.93K (0.50%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx SL Cl I | 913.93K (0.50%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 17 | Fidelity Extended Market Index | 907.14K (0.49%) | 21.28K Increased by +2.35% | Mar 31, 25 |
| 18 | Vanguard Russell 2000 ETF | 884.47K (0.48%) | 49.36K Increased by +5.58% | Apr 30, 25 |
| 19 | Schwab US Small-Cap ETF™ | 769.72K (0.42%) | -392.00 Decreased by -0.05% | Apr 30, 25 |
| 20 | Vanguard Strategic Small-Cap Equity Inv | 763.31K (0.42%) | 0.00 Increased by 0.00% | Mar 31, 25 |