| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Propel Bio Management LLC | 4.12M (29.29%) | -1.01M Decreased by -24.44% | Dec 31, 25 |
| 2 | BlackRock Inc | 4.05M (28.81%) | -920.66K Decreased by -22.73% | Dec 31, 24 |
| 3 | Orbimed Advisors, LLC | 3.22M (22.91%) | 3.22M Increased by +100.00% | Sep 30, 25 |
| 4 | Morgan Stanley - Brokerage Accounts | 2.97M (21.12%) | 2.15M Increased by +72.37% | Sep 30, 25 |
| 5 | Adage Capital Partners Gp LLC | 2.81M (19.98%) | -4.17M Decreased by -148.25% | Dec 31, 25 |
| 6 | RTW INVESTMENTS, LLC | 2.51M (17.82%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 7 | VR Adviser, LLC | 2.21M (15.71%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 8 | Marshall Wace Asset Management Ltd | 1.66M (11.78%) | 1.23M Increased by +74.35% | Dec 31, 25 |
| 9 | Two Sigma Investments LLC | 1.51M (10.77%) | 847.91K Increased by +55.99% | Dec 31, 25 |
| 10 | Simplify Asset Management Inc. | 1.51M (10.71%) | -1.33M Decreased by -88.06% | Dec 31, 25 |
| 11 | Nantahala Capital Management, LLC | 1.45M (10.28%) | -304.74K Decreased by -21.09% | Dec 31, 24 |
| 12 | Alta Fundamental Advisers LLC | 1.40M (9.95%) | -28.50K Decreased by -2.04% | Jun 30, 25 |
| 13 | BML Capital Management LLC | 1.14M (8.08%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 14 | Jane Street Group LLC | 1.09M (7.77%) | 684.74K Increased by +62.63% | Dec 31, 25 |
| 15 | Pathstone Holdings LLC | 1.02M (7.23%) | 17.04K Increased by +1.68% | Dec 31, 25 |
| 16 | Lion Point Capital, LP | 755.00K (5.37%) | 96.45K Increased by +12.77% | Dec 31, 25 |
| 17 | The Toronto-Dominion Bank | 750.00K (5.33%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 18 | Affinity Asset Advisors, LLC | 666.67K (4.74%) | 666.67K Increased by +100.00% | Sep 30, 25 |
| 19 | Boxer Capital Management, LLC | 666.67K (4.74%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 20 | Stonepine Capital Management Llc | 662.67K (4.71%) | 662.67K Increased by +100.00% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Simplify Propel Opportunities ETF | 1.51M (10.71%) | 0.00 Increased by 0.00% | Mar 27, 26 |
| 2 | BlackRock Credit Strategies Instl | 231.56K (1.65%) | -29.79K Decreased by -12.86% | Dec 31, 24 |
| 3 | Biotech Growth Ord | 147.43K (1.05%) | -343.35K Decreased by -232.89% | Nov 30, 25 |
| 4 | Voya Multi-Manager International Sm Cp A | 92.99K (0.66%) | 92.99K Increased by +100.00% | Dec 31, 25 |
| 5 | Fidelity Nasdaq Composite Index | 74.02K (0.53%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 6 | BIT Global Leaders I - I | 47.28K (0.34%) | -100.00K Decreased by -211.52% | Oct 31, 23 |
| 7 | Invesco NASDAQ Future Gen 200 ETF | 41.36K (0.29%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 8 | LUNIS Biotech Growth Opp Fd I a | 26.90K (0.19%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 9 | WEALTHGATE Biotech Fund Inst | 26.90K (0.19%) | 26.90K Increased by +100.00% | Dec 31, 24 |
| 10 | State Street® SPDR® S&P® Intl Sm Cp ETF | 22.33K (0.16%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 11 | BC Biotech S | 20.00K (0.14%) | 0.00 Increased by 0.00% | Jan 31, 24 |
| 12 | SPDR® S&P International Small Cap ETF | 18.92K (0.13%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 13 | SPDR® S&P® International Small Cap ETF | 18.73K (0.13%) | 0.00 Increased by 0.00% | Aug 29, 25 |
| 14 | DFA US Micro Cap I | 15.69K (0.11%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 15 | PVG Emerging Healthcare | 14.47K (0.10%) | 5.26K Increased by +36.39% | Mar 31, 23 |
| 16 | DFA US Small Cap I | 8.07K (0.06%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 17 | Dimensional Global Core Equity USD Acc | 5.87K (0.04%) | 5.00 Increased by +0.09% | Mar 31, 25 |
| 18 | Dimensional Global Small Coms USD Acc | 5.02K (0.04%) | 5.00 Increased by +0.10% | Mar 31, 25 |
| 19 | DFA US Core Equity 1 I | 4.11K (0.03%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 20 | Dimensional World Equity GBP Acc | 3.65K (0.03%) | 1.00 Increased by +0.03% | Mar 31, 25 |