| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 6.80M (12.96%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | HHG PLC | 5.00M (9.53%) | -238.69K Decreased by -4.78% | Sep 30, 25 |
| 3 | BlackRock Inc | 3.60M (6.87%) | 25.34K Increased by +0.70% | Sep 30, 25 |
| 4 | State Street Corporation | 2.82M (5.38%) | 1.09M Increased by +38.54% | Mar 31, 24 |
| 5 | Vanguard Group Inc | 2.60M (4.95%) | 50.72K Increased by +1.95% | Dec 31, 25 |
| 6 | NEA Management Company, LLC | 2.19M (4.17%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 7 | Eventide Asset Management, LLC | 2.09M (3.99%) | -428.98K Decreased by -20.49% | Dec 31, 25 |
| 8 | Bvf Inc | 1.50M (2.85%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | State Street Corp | 1.35M (2.57%) | -28.72K Decreased by -2.13% | Sep 30, 25 |
| 10 | T. Rowe Price Associates, Inc. | 1.28M (2.45%) | -133.93K Decreased by -10.44% | Sep 30, 25 |
| 11 | Novo A/S | 1.26M (2.41%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | Wellington Management Company LLP | 1.24M (2.36%) | 447.14K Increased by +36.12% | Dec 31, 25 |
| 13 | TANG CAPITAL MANAGEMENT LLC | 1.24M (2.36%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 14 | Cadian Capital Management LP | 1.24M (2.36%) | -1.06M Decreased by -85.61% | Jun 30, 24 |
| 15 | Wagonhound Investments, LP | 1.20M (2.29%) | 284.25K Increased by +23.70% | Sep 30, 23 |
| 16 | Geode Capital Management, LLC | 1.06M (2.03%) | 52.90K Increased by +4.98% | Dec 31, 25 |
| 17 | D. E. Shaw & Co LP | 948.16K (1.81%) | 24.65K Increased by +2.60% | Dec 31, 25 |
| 18 | ClearBridge Advisors, LLC | 865.97K (1.65%) | -137.84K Decreased by -15.92% | Dec 31, 25 |
| 19 | Citadel Advisors Llc | 840.22K (1.60%) | -200.32K Decreased by -23.84% | Dec 31, 25 |
| 20 | Polar Capital Holdings PLC | 793.64K (1.51%) | -26.91K Decreased by -3.39% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.83M (3.48%) | 454.01K Increased by +24.86% | Mar 31, 26 |
| 2 | Vanguard US Total Market Shares ETF | 1.41M (2.68%) | 1.77K Increased by +0.13% | Sep 30, 24 |
| 3 | Eventide Gilead N | 1.31M (2.50%) | -121.21K Decreased by -9.26% | Dec 31, 25 |
| 4 | iShares Russell 2000 ETF | 1.02M (1.95%) | -8.32K Decreased by -0.82% | Mar 31, 26 |
| 5 | State Street® SPDR® S&P® Biotech ETF | 966.35K (1.84%) | 56.77K Increased by +5.87% | Mar 31, 26 |
| 6 | Janus Henderson Global Life Sciences D | 805.92K (1.54%) | 123.22K Increased by +15.29% | Jan 31, 26 |
| 7 | Janus Henderson US SMID Cap Growth | 798.07K (1.52%) | -35.31K Decreased by -4.43% | Dec 31, 25 |
| 8 | Janus Henderson Triton D | 778.95K (1.49%) | -19.12K Decreased by -2.45% | Jan 31, 26 |
| 9 | Eventide Healthcare & Life Sciences I | 770.38K (1.47%) | -309.46K Decreased by -40.17% | Dec 31, 25 |
| 10 | MEDICAL BioHealth EUR Acc | 756.50K (1.44%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 11 | Polar Capital Biotech S Inc | 750.00K (1.43%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 12 | American Funds SMALLCAP World A | 724.41K (1.38%) | 724.41K Increased by +100.00% | Mar 31, 26 |
| 13 | Janus Selection Global Life Science AUSD | 700.63K (1.34%) | 265.57K Increased by +37.90% | Jun 30, 24 |
| 14 | Janus Henderson Global Life Sciences | 682.69K (1.30%) | 27.90K Increased by +4.09% | Dec 31, 25 |
| 15 | Janus Henderson US SMID Cap Growth MA | 679.10K (1.30%) | 679.10K Increased by +100.00% | Jun 30, 25 |
| 16 | Vanguard Small Cap Index | 661.67K (1.26%) | 661.67K Increased by +100.00% | Mar 31, 26 |
| 17 | Janus Henderson Glb Life Scn I2 USD | 639.40K (1.22%) | 27.87K Increased by +4.36% | Feb 28, 26 |
| 18 | Janus Global Life Science AUSD | 588.42K (1.12%) | 43.32K Increased by +7.36% | Dec 31, 25 |
| 19 | Franklin Biotechnology Discv A(acc)USD | 555.15K (1.06%) | -71.10K Decreased by -12.81% | Jul 31, 24 |
| 20 | T. Rowe Price New Horizons | 533.02K (1.02%) | 10.69K Increased by +2.00% | Mar 31, 26 |