| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 6.80M (12.94%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | HHG PLC | 5.00M (9.51%) | -238.69K Decreased by -4.78% | Sep 30, 25 |
| 3 | BlackRock Inc | 3.60M (6.86%) | 25.34K Increased by +0.70% | Sep 30, 25 |
| 4 | State Street Corporation | 2.82M (5.37%) | 1.09M Increased by +38.54% | Mar 31, 24 |
| 5 | Vanguard Group Inc | 2.60M (4.94%) | 50.72K Increased by +1.95% | Dec 31, 25 |
| 6 | NEA Management Company, LLC | 2.19M (4.16%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 7 | Eventide Asset Management, LLC | 2.09M (3.99%) | -428.98K Decreased by -20.49% | Dec 31, 25 |
| 8 | Bvf Inc | 1.50M (2.85%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | State Street Corp | 1.35M (2.56%) | -28.72K Decreased by -2.13% | Sep 30, 25 |
| 10 | T. Rowe Price Associates, Inc. | 1.28M (2.44%) | -133.93K Decreased by -10.44% | Sep 30, 25 |
| 11 | Novo A/S | 1.26M (2.41%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | Wellington Management Company LLP | 1.24M (2.36%) | 447.14K Increased by +36.12% | Dec 31, 25 |
| 13 | TANG CAPITAL MANAGEMENT LLC | 1.24M (2.35%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 14 | Cadian Capital Management LP | 1.24M (2.35%) | -1.06M Decreased by -85.61% | Jun 30, 24 |
| 15 | Wagonhound Investments, LP | 1.20M (2.28%) | 284.25K Increased by +23.70% | Sep 30, 23 |
| 16 | Citadel Advisors Llc | 1.04M (1.98%) | -365.81K Decreased by -35.16% | Sep 30, 25 |
| 17 | Geode Capital Management, LLC | 1.01M (1.92%) | -19.59K Decreased by -1.94% | Sep 30, 25 |
| 18 | ClearBridge Advisors, LLC | 1.00M (1.91%) | -23.72K Decreased by -2.36% | Sep 30, 25 |
| 19 | D. E. Shaw & Co LP | 948.16K (1.81%) | 24.65K Increased by +2.60% | Dec 31, 25 |
| 20 | Polar Capital Holdings PLC | 820.55K (1.56%) | -154.45K Decreased by -18.82% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard US Total Market Shares ETF | 1.41M (2.68%) | 1.77K Increased by +0.13% | Sep 30, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.35M (2.58%) | 3.87K Increased by +0.29% | Jan 31, 26 |
| 3 | Eventide Gilead N | 1.31M (2.49%) | -121.21K Decreased by -9.26% | Dec 31, 25 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 1.21M (2.31%) | -42.81K Decreased by -3.52% | Feb 27, 26 |
| 5 | iShares Russell 2000 ETF | 993.29K (1.89%) | 650.05K Increased by +65.44% | Feb 28, 26 |
| 6 | Janus Henderson Triton D | 798.07K (1.52%) | -6.01K Decreased by -0.75% | Dec 31, 25 |
| 7 | Janus Henderson US SMID Cap Growth | 798.07K (1.52%) | -35.31K Decreased by -4.43% | Dec 31, 25 |
| 8 | Eventide Healthcare & Life Sciences I | 770.38K (1.47%) | -309.46K Decreased by -40.17% | Dec 31, 25 |
| 9 | MEDICAL BioHealth EUR Acc | 756.50K (1.44%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 10 | Polar Capital Biotech S Inc | 750.00K (1.43%) | 750.00K Increased by +100.00% | Jan 31, 26 |
| 11 | Janus Selection Global Life Science AUSD | 700.63K (1.33%) | 265.57K Increased by +37.90% | Jun 30, 24 |
| 12 | Janus Henderson Global Life Sciences | 682.69K (1.30%) | 27.90K Increased by +4.09% | Dec 31, 25 |
| 13 | Janus Henderson Global Life Sciences D | 682.69K (1.30%) | 18.51K Increased by +2.71% | Dec 31, 25 |
| 14 | Janus Henderson US SMID Cap Growth MA | 679.10K (1.29%) | 679.10K Increased by +100.00% | Jun 30, 25 |
| 15 | Janus Henderson Glb Life Scn I2 USD | 611.52K (1.16%) | 23.11K Increased by +3.78% | Jan 31, 26 |
| 16 | Janus Global Life Science AUSD | 588.42K (1.12%) | 43.32K Increased by +7.36% | Dec 31, 25 |
| 17 | Franklin Biotechnology Discv A(acc)USD | 555.15K (1.06%) | -71.10K Decreased by -12.81% | Jul 31, 24 |
| 18 | ClearBridge Small Cap Growth | 544.10K (1.04%) | -10.62K Decreased by -1.95% | Jan 31, 26 |
| 19 | ClearBridge Small Cap Growth A | 544.10K (1.04%) | -10.62K Decreased by -1.95% | Jan 31, 26 |
| 20 | T. Rowe Price New Horizons | 522.34K (0.99%) | 62.02K Increased by +11.87% | Jan 31, 26 |