| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 7.68M (14.64%) | 884.56K Increased by +11.52% | Mar 31, 26 |
| 2 | HHG PLC | 6.95M (13.24%) | 880.50K Increased by +12.68% | Mar 31, 26 |
| 3 | BlackRock Inc | 3.85M (7.33%) | 201.24K Increased by +5.23% | Mar 31, 26 |
| 4 | State Street Corporation | 2.82M (5.38%) | 1.09M Increased by +38.54% | Mar 31, 24 |
| 5 | Vanguard Group Inc | 2.60M (4.95%) | 50.72K Increased by +1.95% | Dec 31, 25 |
| 6 | Vanguard Capital Management, LLC | 2.41M (4.60%) | 2.41M Increased by +100.00% | Mar 31, 26 |
| 7 | NEA Management Company, LLC | 2.19M (4.17%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 8 | FMR Inc | 1.97M (3.75%) | 1.32M Increased by +67.11% | Mar 31, 26 |
| 9 | State Street Corp | 1.94M (3.71%) | -199.71K Decreased by -10.27% | Mar 31, 26 |
| 10 | T. Rowe Price Associates, Inc. | 1.72M (3.27%) | 297.05K Increased by +17.30% | Mar 31, 26 |
| 11 | Bvf Inc | 1.58M (3.02%) | 89.44K Increased by +5.64% | Mar 31, 26 |
| 12 | Vanguard Portfolio Management, LLC | 1.43M (2.73%) | 1.43M Increased by +100.00% | Mar 31, 26 |
| 13 | Eventide Asset Management, LLC | 1.41M (2.69%) | -684.71K Decreased by -48.60% | Mar 31, 26 |
| 14 | Wellington Management Company LLP | 1.33M (2.54%) | 96.98K Increased by +7.27% | Mar 31, 26 |
| 15 | Novo A/S | 1.32M (2.53%) | 60.97K Increased by +4.60% | Mar 31, 26 |
| 16 | Geode Capital Management, LLC | 1.26M (2.40%) | 197.08K Increased by +15.64% | Mar 31, 26 |
| 17 | TANG CAPITAL MANAGEMENT LLC | 1.24M (2.36%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 18 | Cadian Capital Management LP | 1.24M (2.35%) | -1.06M Decreased by -85.61% | Jun 30, 24 |
| 19 | Wagonhound Investments, LP | 1.20M (2.29%) | 284.25K Increased by +23.70% | Sep 30, 23 |
| 20 | TCG Crossover Management, LLC | 1.06M (2.02%) | 1.00M Increased by +94.16% | Mar 31, 26 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.65M (3.14%) | -185.13K Decreased by -11.23% | Jun 30, 26 |
| 2 | T. Rowe Price Health Sciences | 1.49M (2.84%) | 199.43K Increased by +13.40% | Jun 30, 26 |
| 3 | Vanguard US Total Market Shares ETF | 1.41M (2.68%) | 1.77K Increased by +0.13% | Sep 30, 24 |
| 4 | Strategic Advisers Fidelity US TtlStk | 1.31M (2.49%) | 270.87K Increased by +20.75% | May 31, 26 |
| 5 | iShares Russell 2000 ETF | 1.23M (2.34%) | 7.29K Increased by +0.59% | Jun 30, 26 |
| 6 | Vanguard Small Cap Index | 1.19M (2.27%) | 519.70K Increased by +43.72% | Jun 30, 26 |
| 7 | State Street® SPDR® S&P® Biotech ETF | 1.06M (2.01%) | -23.46K Decreased by -2.22% | Jun 30, 26 |
| 8 | T. Rowe Price New Horizons | 823.45K (1.57%) | 275.67K Increased by +33.48% | Jun 30, 26 |
| 9 | Janus Henderson Global Life Sciences | 808.98K (1.54%) | 126.29K Increased by +15.61% | Mar 31, 26 |
| 10 | Janus Henderson Global Life Sciences D | 806.71K (1.54%) | -2.27K Decreased by -0.28% | Apr 30, 26 |
| 11 | Polar Capital Biotech S Inc | 800.92K (1.53%) | 533.13K Increased by +66.56% | May 31, 26 |
| 12 | Janus Henderson US SMID Cap Growth | 778.95K (1.48%) | -19.12K Decreased by -2.45% | Mar 31, 26 |
| 13 | Janus Henderson Triton D | 761.39K (1.45%) | -17.56K Decreased by -2.31% | Apr 30, 26 |
| 14 | MEDICAL BioHealth EUR Acc | 756.50K (1.44%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 15 | Janus Global Life Science AUSD | 734.53K (1.40%) | 146.11K Increased by +19.89% | Mar 31, 26 |
| 16 | American Funds SMALLCAP World A | 724.41K (1.38%) | 724.41K Increased by +100.00% | Mar 31, 26 |
| 17 | Eventide Gilead N | 709.13K (1.35%) | -600.00K Decreased by -84.61% | Mar 31, 26 |
| 18 | Janus Selection Global Life Science AUSD | 700.63K (1.34%) | 265.57K Increased by +37.90% | Jun 30, 24 |
| 19 | Eventide Healthcare & Life Sciences I | 690.85K (1.32%) | -79.54K Decreased by -11.51% | Mar 31, 26 |
| 20 | Vanguard Small Cap Growth Index Inv | 686.32K (1.31%) | 316.01K Increased by +46.04% | Jun 30, 26 |