| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Baker Bros Advisors LP | 2.14M (17.15%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | RTW INVESTMENTS, LLC | 1.99M (15.96%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | HHG PLC | 1.84M (14.75%) | -349.06K Decreased by -18.94% | Sep 30, 25 |
| 4 | Vanguard Group Inc | 1.81M (14.48%) | -3.16K Decreased by -0.17% | Dec 31, 25 |
| 5 | venBio Select Advisor LLC | 1.81M (14.47%) | -25.50K Decreased by -1.41% | Dec 31, 25 |
| 6 | Paulson & Company Inc | 1.71M (13.67%) | -200.00K Decreased by -11.71% | Dec 31, 25 |
| 7 | BlackRock Inc | 1.56M (12.49%) | 120.99K Increased by +7.76% | Sep 30, 25 |
| 8 | State Street Corp | 658.10K (5.27%) | -32.62K Decreased by -4.96% | Sep 30, 25 |
| 9 | State Street Corporation | 624.94K (5.00%) | -75.80K Decreased by -12.13% | Mar 31, 24 |
| 10 | UBS Group AG | 505.71K (4.05%) | 184.21K Increased by +36.43% | Jun 30, 25 |
| 11 | Wellington Management Company LLP | 461.40K (3.69%) | 56.95K Increased by +12.34% | Dec 31, 25 |
| 12 | Geode Capital Management, LLC | 451.74K (3.62%) | 5.51K Increased by +1.22% | Dec 31, 25 |
| 13 | FMR Inc | 439.40K (3.52%) | 38.26K Increased by +8.71% | Dec 31, 25 |
| 14 | Marshall Wace Asset Management Ltd | 395.40K (3.17%) | -65.25K Decreased by -16.50% | Sep 30, 23 |
| 15 | Holocene Advisors, LP | 390.55K (3.13%) | 390.55K Increased by +100.00% | Mar 31, 25 |
| 16 | Adage Capital Partners Gp LLC | 376.16K (3.01%) | 184.55K Increased by +49.06% | Jun 30, 25 |
| 17 | William Blair Investment Management, LLC | 354.22K (2.84%) | -57.58K Decreased by -16.26% | Dec 31, 25 |
| 18 | T. Rowe Price Associates, Inc. | 352.52K (2.82%) | -155.94K Decreased by -44.24% | Sep 30, 25 |
| 19 | AllianceBernstein L.P. | 339.75K (2.72%) | -21.22K Decreased by -6.25% | Dec 31, 23 |
| 20 | Woodline Partners LP | 317.43K (2.54%) | 8.32K Increased by +2.62% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard US Total Market Shares ETF | 578.31K (4.63%) | 388.00 Increased by +0.07% | Sep 30, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 576.75K (4.62%) | 1.02K Increased by +0.18% | Feb 28, 26 |
| 3 | Janus Concentrated Growth CF | 429.42K (3.44%) | -92.64K Decreased by -21.57% | Dec 31, 25 |
| 4 | Janus Henderson Forty S | 429.42K (3.44%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 5 | iShares Russell 2000 ETF | 414.60K (3.32%) | -3.38K Decreased by -0.82% | Mar 31, 26 |
| 6 | Vanguard Small Cap Index | 412.66K (3.30%) | 1.10K Increased by +0.27% | Feb 28, 26 |
| 7 | Janus Henderson Opportunistic Alpha MA | 319.65K (2.56%) | 319.62K Increased by +99.99% | Jun 30, 24 |
| 8 | SPDR® S&P Biotech ETF | 299.46K (2.40%) | 670.00 Increased by +0.22% | Aug 31, 25 |
| 9 | Polar Capital Biotech S Inc | 255.00K (2.04%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 10 | Vanguard Health Care Inv | 241.20K (1.93%) | 45.99K Increased by +19.07% | Dec 31, 25 |
| 11 | Janus Henderson Research D | 226.92K (1.82%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 12 | Janus Henderson US Research Growth Eq | 226.92K (1.82%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 13 | Janus Selection Global Life Science AUSD | 225.04K (1.80%) | -19.20K Decreased by -8.53% | Mar 31, 24 |
| 14 | T. Rowe Price Health Sciences | 219.75K (1.76%) | -30.45K Decreased by -13.86% | Sep 30, 24 |
| 15 | RTW Biotech Opportunities Ord | 213.44K (1.71%) | -1.38K Decreased by -0.65% | Jun 30, 25 |
| 16 | Vanguard Institutional Extnd Mkt Idx Tr | 202.96K (1.62%) | 1.91K Increased by +0.94% | Feb 28, 26 |
| 17 | Artisan International Small-Mid Investor | 198.71K (1.59%) | -15.54K Decreased by -7.82% | Sep 30, 24 |
| 18 | Artisan Non-U.S. Small-Mid Growth Comp | 198.71K (1.59%) | -15.54K Decreased by -7.82% | Sep 30, 24 |
| 19 | State Street® SPDR® S&P® Biotech ETF | 196.41K (1.57%) | 2.94K Increased by +1.50% | Mar 31, 26 |
| 20 | Janus Henderson Contrarian D | 191.73K (1.53%) | 0.00 Increased by 0.00% | Jan 31, 26 |