| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Paradigm Biocapital Advisors LP | 6.18M (13.04%) | 1.42M Increased by +22.98% | Mar 31, 26 |
| 2 | BlackRock Inc | 5.11M (10.78%) | 203.31K Increased by +3.98% | Mar 31, 26 |
| 3 | Affinity Asset Advisors, LLC | 5.05M (10.65%) | 1.85M Increased by +36.64% | Mar 31, 26 |
| 4 | RA Capital Management, LLC | 5.00M (10.54%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 5 | HHG PLC | 4.98M (10.49%) | -533.21K Decreased by -10.71% | Mar 31, 26 |
| 6 | Vestal Point Capital LP | 4.47M (9.44%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 7 | Frazier Life Sciences Management, L.P. | 4.42M (9.33%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 8 | Vanguard Group Inc | 3.89M (8.21%) | 1.67M Increased by +42.83% | Dec 31, 25 |
| 9 | Citadel Advisors Llc | 3.83M (8.09%) | 60.68K Increased by +1.58% | Mar 31, 26 |
| 10 | Orbimed Advisors, LLC | 3.60M (7.60%) | 1.48M Increased by +41.01% | Mar 31, 26 |
| 11 | State Street Corp | 3.57M (7.53%) | 380.52K Increased by +10.66% | Mar 31, 26 |
| 12 | Vanguard Capital Management, LLC | 3.01M (6.34%) | 3.01M Increased by +100.00% | Mar 31, 26 |
| 13 | Woodline Partners LP | 2.75M (5.80%) | -447.23K Decreased by -16.26% | Mar 31, 26 |
| 14 | The Goldman Sachs Group Inc | 1.95M (4.11%) | 1.17M Increased by +59.90% | Mar 31, 26 |
| 15 | venBio Select Advisor LLC | 1.88M (3.95%) | -1.43M Decreased by -76.00% | Mar 31, 26 |
| 16 | Point72 Asset Management, L.P. | 1.68M (3.54%) | -214.27K Decreased by -12.75% | Mar 31, 26 |
| 17 | Millennium Management LLC | 1.61M (3.40%) | 704.76K Increased by +43.70% | Mar 31, 26 |
| 18 | Balyasny Asset Management LLC | 1.59M (3.35%) | -45.44K Decreased by -2.86% | Mar 31, 26 |
| 19 | Geode Capital Management, LLC | 1.51M (3.19%) | 67.89K Increased by +4.48% | Mar 31, 26 |
| 20 | ADAR1 Capital Management LLC | 1.47M (3.09%) | 74.19K Increased by +5.06% | Mar 31, 26 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | State Street® SPDR® S&P® Biotech ETF | 2.42M (5.10%) | -53.88K Decreased by -2.23% | Jun 30, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.34M (4.92%) | 75.88K Increased by +3.25% | Jun 30, 26 |
| 3 | iShares Russell 2000 ETF | 1.86M (3.92%) | 11.02K Increased by +0.59% | Jun 30, 26 |
| 4 | Vanguard Institutional Extnd Mkt Idx Tr | 715.09K (1.51%) | 37.81K Increased by +5.29% | Jun 30, 26 |
| 5 | abrdn Life Sciences Investors | 675.09K (1.42%) | 130.34K Increased by +19.31% | Jun 30, 26 |
| 6 | iShares Russell 2000 Value ETF | 660.76K (1.39%) | -4.56K Decreased by -0.69% | Jun 30, 26 |
| 7 | Fidelity Small Cap Index | 654.15K (1.38%) | 6.15K Increased by +0.94% | Apr 30, 26 |
| 8 | Janus Henderson Gbl Life Sciences Divers | 642.30K (1.35%) | 642.30K Increased by +100.00% | Sep 30, 25 |
| 9 | Janus Henderson Global Life Sciences | 633.49K (1.34%) | 934.00 Increased by +0.15% | Mar 31, 26 |
| 10 | Janus Henderson Global Life Sciences D | 631.38K (1.33%) | -2.10K Decreased by -0.33% | Apr 30, 26 |
| 11 | Janus Global Life Science AUSD | 580.79K (1.22%) | 21.17K Increased by +3.65% | Mar 31, 26 |
| 12 | Janus Henderson Glb Life Scn I2 USD | 575.62K (1.21%) | -3.52K Decreased by -0.61% | May 31, 26 |
| 13 | Stt Strt®SPDR®S&PKenshoNwEcosComposETF | 566.20K (1.19%) | 710.00 Increased by +0.13% | Jun 30, 26 |
| 14 | iShares Biotechnology ETF | 439.60K (0.93%) | 4.55K Increased by +1.04% | Jun 30, 26 |
| 15 | Vanguard Russell 2000 ETF | 407.61K (0.86%) | 68.50K Increased by +16.80% | Jun 30, 26 |
| 16 | Biotech Growth Ord | 399.40K (0.84%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 17 | Russell 2000 Equity Index Fund B | 398.24K (0.84%) | 3.67K Increased by +0.92% | Mar 31, 26 |
| 18 | Russell 2000 Index Non-Lendable Fund | 398.24K (0.84%) | 241.93K Increased by +60.75% | Mar 31, 26 |
| 19 | State St Russell Sm/Mid Cp® Indx SL Cl I | 381.70K (0.80%) | 0.00 Increased by 0.00% | Jun 30, 26 |
| 20 | Fidelity Extended Market Index | 308.00K (0.65%) | -7.87K Decreased by -2.55% | May 31, 26 |