| Rank | Holder | SharesFloat % | Change | Date reported | 
|---|---|---|---|---|
| 1 | FMR Inc | 4.35M (17.42%) | -65.12K   Decreased by -1.50%  |  Sep 30, 24 | 
| 2 | RA Capital Management, LLC | 3.29M (13.17%) | 0.00   Increased by 0.00%  |  Jun 30, 24 | 
| 3 | Farallon Capital Management, L.L.C. | 3.15M (12.62%) | 210.36K   Increased by +6.68%  |  Sep 30, 24 | 
| 4 | T. Rowe Price Associates, Inc. | 2.91M (11.65%) | 400.72K   Increased by +13.77%  |  Sep 30, 24 | 
| 5 | BlackRock Inc | 2.84M (11.37%) | 469.43K   Increased by +16.54%  |  Sep 30, 24 | 
| 6 | Cormorant Asset Management, LLC | 2.79M (11.18%) | 0.00   Increased by 0.00%  |  Sep 30, 24 | 
| 7 | Vanguard Group Inc | 2.03M (8.14%) | 107.92K   Increased by +5.31%  |  Sep 30, 24 | 
| 8 | Viking Global Investors LP | 1.97M (7.89%) | 310.08K   Increased by +15.75%  |  Sep 30, 24 | 
| 9 | Wellington Management Company LLP | 1.59M (6.37%) | -188.90K   Decreased by -11.88%  |  Sep 30, 24 | 
| 10 | Polar Capital Holdings PLC | 1.10M (4.42%) | -251.76K   Decreased by -22.83%  |  Sep 30, 24 | 
| 11 | Integral Health Asset Management, LLC | 1.05M (4.21%) | -50.00K   Decreased by -4.76%  |  Sep 30, 24 | 
| 12 | Point72 Asset Management, L.P. | 1.03M (4.13%) | -343.63K   Decreased by -33.32%  |  Jun 30, 24 | 
| 13 | Goldman Sachs Group Inc | 1.03M (4.11%) | 701.76K   Increased by +68.35%  |  Sep 30, 24 | 
| 14 | Woodline Partners LP | 1.00M (4.02%) | 940.27K   Increased by +93.59%  |  Sep 30, 24 | 
| 15 | Ikarian Capital, LLC | 979.46K (3.92%) | 465.36K   Increased by +47.51%  |  Dec 31, 23 | 
| 16 | Pictet Asset Manangement SA | 918.57K (3.68%) | 4.79K   Increased by +0.52%  |  Sep 30, 24 | 
| 17 | Jennison Associates LLC | 917.53K (3.67%) | -34.44K   Decreased by -3.75%  |  Sep 30, 24 | 
| 18 | Siren, L.L.C. | 903.23K (3.62%) | 903.23K   Increased by +100.00%  |  Sep 30, 24 | 
| 19 | State Street Corp | 855.81K (3.43%) | 53.96K   Increased by +6.31%  |  Sep 30, 24 | 
| 20 | Geode Capital Management, LLC | 746.15K (2.99%) | 63.76K   Increased by +8.54%  |  Sep 30, 24 | 
| Rank | Holder | SharesFloat % | Change | Date reported | 
|---|---|---|---|---|
| 1 | Fidelity Select Biotechnology | 1.71M (6.85%) | 0.00   Increased by 0.00%  |  Sep 30, 24 | 
| 2 | HBM Healthcare Investments AG Ord | 1.35M (5.40%) | 0.00   Increased by 0.00%  |  Dec 31, 23 | 
| 3 | T. Rowe Price Health Sciences | 1.11M (4.44%) | -10.79K   Decreased by -0.97%  |  Sep 30, 24 | 
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.08M (4.32%) | -12.52K   Decreased by -1.16%  |  Nov 30, 24 | 
| 5 | Polar Capital Biotech S Inc | 1.00M (4.01%) | 0.00   Increased by 0.00%  |  Sep 30, 24 | 
| 6 | T. Rowe Price New Horizons | 901.56K (3.61%) | -2.84K   Decreased by -0.32%  |  Sep 30, 24 | 
| 7 | US Small-Cap Growth II Equity Comp | 901.56K (3.61%) | 30.99K   Increased by +3.44%  |  Sep 30, 24 | 
| 8 | iShares Russell 2000 ETF | 887.04K (3.55%) | 0.00   Increased by 0.00%  |  Nov 30, 24 | 
| 9 | Fidelity Global Innovators Cl F | 827.11K (3.31%) | -4.15K   Decreased by -0.50%  |  Sep 30, 24 | 
| 10 | Fidelity® Select Biotechnology | 549.31K (2.20%) | -40.08K   Decreased by -7.30%  |  Nov 30, 23 | 
| 11 | American Century Small Cap Growth Inv | 491.80K (1.97%) | 81.40K   Increased by +16.55%  |  Sep 30, 24 | 
| 12 | American Century U.S. Small Cap Growth | 491.80K (1.97%) | 81.40K   Increased by +16.55%  |  Sep 30, 24 | 
| 13 | Fidelity Series Small Cap Opps | 480.60K (1.92%) | -19.20K   Decreased by -4.00%  |  Sep 30, 24 | 
| 14 | Fidelity Advisor® Biotechnology I | 476.92K (1.91%) | -94.61K   Decreased by -19.84%  |  Nov 30, 23 | 
| 15 | Pictet-Biotech P USD | 472.51K (1.89%) | -278.00   Decreased by -0.06%  |  Sep 30, 24 | 
| 16 | Vanguard Institutional Extnd Mkt Idx Tr | 470.16K (1.88%) | 2.30K   Increased by +0.49%  |  Nov 30, 24 | 
| 17 | Fidelity VIP Mid Cap Initial | 450.00K (1.80%) | 235.30K   Increased by +52.29%  |  Oct 31, 24 | 
| 18 | Pictet Biotech | 370.00K (1.48%) | 370.00K   Increased by +100.00%  |  Mar 31, 24 | 
| 19 | Pictet-Global Megatrend Sel I USD | 358.44K (1.44%) | 68.25K   Increased by +19.04%  |  Sep 30, 24 | 
| 20 | Wellington Global Hlthcr Eq USD G Ac | 345.12K (1.38%) | -7.43K   Decreased by -2.15%  |  May 31, 24 |